Filtyp
Gold shell-isolated nanoparticles (AuSHINs) are promising photothermal therapy (PTT) agents for cancer treatment due to their excellent photoconversion efficiency, biocompatibility, colloidal stability, and tunable properties, including size, shape, and surface functionalization. However, their therapeutic efficacy in in vitro assays is often limited by poor cellular uptake and lysosomal entrapmen
Context: Land-use intensification to increase yields is often detrimental to biodiversity undermining the provision of ecosystem services. However, it is questionable if ecosystem service providers contribute to ecological intensification by achieving the same or higher yields than conventional high-intensity agriculture. Objectives: In this study, we aimed to disentangle the effects of local and
Human activities in deciduous forests over the past centuries have influenced associated species. To reduce extinction risks and mitigate population declines, there is growing interest in forest conservation and restoration, including initiatives by the European Union (EU). For resulting restoration and conservation practices to succeed, it is essential to know which forest characteristics promote
Here we report the results from exploratory analysis using a Bayesian network approach of data originally derived from a large North European study of type 2 diabetes (T2D) conducted by the IMI DIRECT consortium. 3029 individuals (795 with T2D and 2234 without) within 7 different study centres provided data comprising genotypes, proteins, metabolites, gene expression measurements and many differen
The long-standing debate in the scientific community about whether ferroelectricity or ferroelasticity is the key property influencing the optoelectronic behavior of metal halide perovskites continues. In this study, we experimentally investigate the temperature dependence of photoluminescence from CsPb(Br1−xClx)3 nanowires and their heterojunctions. Our findings show an enhancement of the exciton
Cluster superlattice membranes constitute a novel 2D material, comprising a cluster superlattice sandwiched between a graphene support and an amorphous carbon embedding matrix. They offer a platform for investigating phenomena at the few atom to small cluster level with lateral averaging techniques. The amorphous carbon matrix provides mechanical and thermal stability to the cluster array, but alt
Pollinators are estimated to benefit the reproduction of three-quarters of global leading crop species and contribute to 3%–8% of the total global food production. Ongoing declines in pollinator populations have raised concerns about repercussions for food security. Thus, there is a need to better understand how agricultural yields depend on pollinator abundance. Here, we established yield–pollina
In the pursuit of more sustainable agriculture, weeds play a dual role by threatening crop production and simultaneously contributing to farmland biodiversity. Management actions such as the use of fertilisers (fertilisation) may change weed abundance and community composition with consequences for both weed–crop competition and biodiversity. Alleviating the balance between yield and biodiversity
Organismal abundance tends to decline with increasing body size. Metabolic theory links this size structure with energy use and productivity, postulating a size–abundance slope of −0.75 that is invariant across environments. We tested the robustness of this relationship across gradients of protist species richness (1–6 species), temperature (15°C–25°C) and time. Using replicated microcosms, we pro
The peptide Ac-KGSFSIQYTYHVD-CONH₂ (KD), derived from residues 37–49 of human semenogelin I, forms a pH-responsive hydrogel in an aqueous environment with tunable mechanical properties that evolve over time. We hypothesize that KD self-assembles into a hydrogel through a pH-dependent mechanism involving predominantly a change in histidine protonation state, leading to structural transformations th
The investigation of carbon monoxide (CO) adsorption on the unreconstructed Ir(100)-(1 × 1) surface under ultra-high vacuum (UHV) conditions is studied with scanning tunneling microscopy (STM), low-energy electron diffraction (LEED), and high-resolution core-level spectroscopy (HRCLS). At a low coverage of 0.5 ML (monolayer), CO molecules adopt a previously documented c(2 × 2) structure, having CO
Resource competition between wild pollinators and managed honeybees (Apis mellifera) has the potential to detrimentally impact insect biodiversity as well as wild plant and crop pollination. As honeybees are central place foragers, their competitive impact on wild bees is expected to be structured by hive proximity, in conjunction with foraging decisions related to landscape-level resource availab
Sphingosine-1-phosphate receptors (S1PRs) are promising therapeutic targets in cardiovascular disease, including ischemic stroke. However, important spatiotemporal information for alterations of S1PR expression is lacking. Here, we investigated the role of S1PR3 in ischemic stroke in rodent models and patient samples. We show that S1PR3 is acutely upregulated in perilesional reactive astrocytes af
Thermally sprayed Al2O3 coatings containing graphene nano platelets (GNP) have been shown to exhibit improved wear resistance. To understand the positive influence of GNP on wear properties, scanning transmission X-ray microscopy (STXM) analyses were performed to determine the structural and chemical changes that occur on the GNP and alumina matrix after wear tests. STXM results acquired at the C
The growing interest in lignin valorization in the past decades calls for analytical techniques for lignin characterization, ranging from wet chemistry techniques to highly sophisticated chromatographic and spectroscopic methods. One of the key parameters to consider is the molecular weight profile of lignin, which is routinely determined by size-exclusion chromatography; however, this is by no me
This article compares Swedish social workers, teachers, and journalists’ experiences of workplace violence. It addresses similarities and differences between the three professional groups in terms of who exposed them to workplace violence, what it was about, and what triggered it. The article is based on an online survey study, and the findings suggest that consumerrelated violence from target groThis article compares Swedish social workers, teachers, and journalists’ experiences of workplace violence. It addresses similarities and differences between the three professional groups in terms of who exposed them to workplace violence, what it was about, and what triggered it. The article is based on an online survey study, and the findings suggest that consumer-related violence from target gr
The ability of small lipophilic molecules to penetrate the blood-brain barrier through transmembrane diffusion has enabled researchers to explore new diagnostics and therapies for brain disorders. Until now, therapies targeting the brain have mainly relied on biochemical mechanisms, while electrical treatments such as deep brain stimulation often require invasive procedures. An alternative to impl
PURPOSE: The aim of this study was to set up reliable and reproducible culture conditions for 3D tumoroids derived from non-small cell lung cancer (NSCLC) cell lines to enable greater opportunity for successful cultivation of patient-derived samples.METHODS: Four NSCLC cell lines, two adenocarcinomas (A549, NCI-H1975) and two squamous cell carcinomas (HCC-95, HCC-1588), were first cultured in trad
Background: Food biodiversity in human diets has potential co-benefits for both public health and sustainable food systems. However, current evidence on the potential relationship between food biodiversity and cancer risk, and particularly gastrointestinal cancers typically related to diet, remains limited. This study evaluated how dietary species richness (DSR) was associated with gastrointestina
Alexander disease (AxD) is a rare and severe neurodegenerative disorder caused by mutations in glial fibrillary acidic protein (GFAP). While the exact disease mechanism remains unknown, previous studies suggest that mutant GFAP influences many cellular processes, including cytoskeleton stability, mechanosensing, metabolism, and proteasome function. While most studies have primarily focused on GFAP
