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This chapter provides an overview of the main concepts in mechanobiology and touches upon the experimental models that are most frequently used to study mechanobiology on a cell and tissue level. It focuses on the use of computational techniques and algorithms to simulate mechanobiological processes, and their prospective potential in clinical applications. It covers how computational algorithms h
Treatment with anti-CD20 antibodies is only moderately efficient in chronic lymphocytic leukemia (CLL), a feature which has been explained by the inherently low CD20 expression in CLL. It has been shown that CD20 is epigenetically regulated and that histone deacetylase inhibitors (HDACis) can increase CD20 expression in vitro in CLL. To assess whether HDACis can upregulate CD20 also in vivo in CLL
Objective To evaluate the implementation of automated chest compression cardiopulmonary resuscitation (ACC-CPR) after out-of-hospital cardiac arrest (OHCA) in Sweden during the years 2011 through 2015. The association between ACC-CPR and 30-day survival was studied as a secondary objective. Methods The Swedish cardiopulmonary resuscitation registry is a prospectively recorded nationwide registry o
Brain-derived neurotrophic factor (BDNF) is an important protein for neuroplasticity and neurogenesis. In this thesis the role of BDNF, in suicidal behaviour was investigated with focus on possible risk factors for suicidal behaviour such as avoidant focused coping, dysfuntional personality traits like impulsiveness and hyperactivity of the Hypothalamic-Pituitary-Adrenal (HPA) axis.Paper I: The a
In almost all countries in the Middle East and North Africa (MENA) region, power sectors are characterized by a high degree of vertical integration and state control. However, several countries have undertaken reforms in order to open up the power market for private sector involvement particularly in relation to renewable energy (RE) sourced electricity generation. The majority of the MENA countri
While research on the design of heterogeneous concurrent systems has a long and rich history, a unified design methodology and tool support has not emerged so far, and thus the creation of such systems remains a difficult, time-consuming and error-prone process. The absence of principled support for system evaluation and optimization at high abstraction levels makes the quality of the resulting im
BACKGROUND: Androgen insensitivity is caused by mutations in the androgen receptor gene, and is a common etiological factor to ambiguous genitalia in the newborn. This article discusses the role of androgens in sex differentiation, the structure and function of the androgen receptor, the genetic background to androgen insensitivity as well as clinical aspects. MATERIAL AND METHODS: The article is
Attneave's (1968) pointing triangle illusion consists of a display of ipsilateral triangles. Perceiving the display results in the illusion that the triangles point in a certain direction. Spontaneous switches in pointing direction are observed. Blink frequency significantly decreases before the switches witnessing for a nonspecific preparation process to perceptual and motor response events. Sacc
‘Flight shame’ describes an unease about the climate implications of air travel, and bears evidence of a change in social norms that have so far associated flying with social status. This paper discusses whether Fridays for Future demonstrations and ensuing flight shame have influenced social norms regarding the desirability of air travel, and whether this is measurable in a decline in air travel,
1. Dementia is a clinical syndrome with several causes whichcreates impairments in mental ability, personality, affect andsocialisation.2. Information from family members can be very useful in theearly identification of cognitive impairment.3. Patients presenting with cognitive impairment should be evaluatedfor potentially reversible causes, with a range of laboratorytests and investigations.4. Sh
The Swedish policy response to Covid-19 is exceptional by international comparison. This column explains how the approach is decided by three articles in the Swedish constitution. The first guarantees the freedom of movement for Swedish citizens, ruling out nationwide lockdowns. The second establishes unique independence for public agencies, allowing them to design the policy response to the pande
The members of the genus Caldicellulosiruptor have the potential for future integration into a biorefinery system due to their capacity to generate hydrogen close to the theoretical limit of 4 mol H2/mol hexose, use a wide range of sugars and can grow on numerous lignocellulose hydrolysates. However, members of this genus are unable to survive in high sugar concentrations, limiting their ability t
This chapter concerns disabled people’s experiences of barriers to accessing sexuality. It draws on an analysis of materials produced in ten projects by civil society organisations, including self-advocacy organisations, sexual rights organisations and organisations working on behalf of disabled people. These materials comprise books, handbooks, videos, websites and other online materials, and are
Aim of the studyRates of bystander CPR are increasing, yet mortality after out-of-hospital cardiac arrest (OHCA) remains high. The aim of this survey was to explore public knowledge and attitudes to CPR. Our hypotheses were that recent CPR training (< 5 years) would be associated with a high-quality response in a case vignette of OHCA with agonal breathing, and associated with an interest to becom
Droplet microfluidics is a powerful method to characterize chemical reactions at high throughput. Often detection is performed via in-line optical readout, which puts high demands on the detection system and makes detection of low concentration substrates challenging. Here, we have developed a droplet acoustofluidic chip for time-controlled microbead-based reactions that is combined with off-line
We present a microfluidic system to control the position of particles (polystyrene beads or astrocyte cells) in hydrogel droplets using bulk acoustic standing waves. Droplets comprising hydrogel precursor solution, photoinitiator and (bio-)particles were generated and acoustic forces focused the beads to the droplet center line. Droplets were cross-linked by exposure to UV-light. With the acoustic
