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Objectives Biologic agents have dramatically changed treatment of rheumatoid arthritis (RA). To date only scarce head-To-head data exist especially when the biological therapies are given as monotherapy without concomitant disease modifying drugs (DMARDs). Thus the objective of the current study is to evaluate treatment response of all available biological therapies with special focus on utility (

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Friedreich’s ataxia (FRDA) is an autosomal recessive neurodegenerative disease caused by defeciency in frataxin, a highly conserved protein central to iron homeostasis in mirochondria. The function of frataxin is related to its capability to bind, store and deliver iron to different biochemical process such as iron-sulfur cluster assembly and heme biosynthesis. Most FRDA pateints have extended GAA

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Popular Abstract in English In the past decade, mobile wireless communication have had a tremendous impact on the way people perceive and use mobile devices, most popularly the mobile phone. Apart from making phone calls, they are capable of being cameras to take pictures and videos, able to browse the Internet, do video calling and much more just like an yesteryear computer. The wireless medium iThe demand for spectrum resources in cellular systems worldwide has seen a tremendous escalation in the recent past. The mobile phones of today are capable of being cameras taking pictures and videos, able to browse the Internet, do video calling and much more than an yesteryear computer. Due to the variety and the amount of information that is being transmitted the demand for spectrum resources i

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Rapporten redovisar resultatet från en utrymningsövning som genomfördes från ett 8-vagnars tunnelbanetåg som stannat i en tunnel. Orsaken till att tåget stannat skulle vara brand i tåget eller i tunneln. Försöket genomfördes en natt mellan den 20 och 21 maj 1999 i tunnelbanan i Stockholm. Platsen för försöket var mellan stationerna Stadion och Östermalms torg. Totalt medverkade 143 försökspersoner

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The Church has been a dominant actor in the history of care and social support, but it met several restrictions during the 20th Century. The Church of Sweden now has,since the separation from the state A.D. 2000, the possibility to act as a "welfare entrepreneur". But the willingness to do so seems limited. Even if innovative examples are seen the parishes hesitate for organisational and ideologic

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Background : Currently, antiretroviral therapy (ART) is recommended for all HIV-positive patients with tuberculosis (TB). The timing of ART during the course of anti-TB treatment is based on CD4 cell counts. Access to CD4 cell testing is not universally available; this constitutes an obstacle for the provision of ART in low-income countries. Objective : To determine clinical variables associated w

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With this work we have investigated how the air in the air cylinders of portable breathing apparatuses is heated during work in hot environments equal to those of interior fire extinguishing. The laws, regulations and standards concerning breathing apparatuses have been reviewed. We describe the theoretical relationships between heating and cooling as a result of air outtake and compare these to e

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Frågeställningen i uppsatsen är: hur hanterade intagna vistelsen i häktet? Använde de sig av strategier för att uthärda inlåsningen? I så fall vilka? Bakgrunden till uppsatsen är främst den senaste tidens intensiva debatter gällande förhållanden i svenska häkten, diskussioner har bland annat gällt långa häktningstider och stränga restriktioner. Vidare grundar sig mitt intresse främst på ett tidiga

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Background: The Influenza – Monitoring Vaccine Effectiveness in Europe (I-MOVE/I-MOVE+) and Vaccine Effectiveness, Burden and Impact Studies (VEBIS) hospital networks have conducted seasonal multicentre, test-negative, case–control studies in Europe to measure influenza vaccine effectiveness (IVE) since 2015/16. We measured the effect of chronic conditions on VE of influenza A subtypes among older

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Cell culturing methods are increasingly used to reduce and replace the use of live animals in biomedical research and chemical toxicity testing. Although live animals are avoided when using cell culturing methods, they often contain animal-derived components of which one of the most commonly used is foetal bovine serum (FBS). FBS is added to cell culture media among other supplements to support ce

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In secondary-school English-as-a-foreign-language (EFL) classrooms worldwide, English tends to be used alongside the society or community majority language (Brevik & Rindal 2020; Tsagari & Diakou 2015; Üstünel 2016), and research reveals greater participation and positive attitudes among students when translanguaging is permitted (Ebe 2016; Kleyn 2016; Saxena 2009; Ollerhead 2019; Seltzer

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This study investigates whether downside risk, captured through downside beta, is a priced risk factor in the Swedish stock market. Using monthly data from 1990 to 2019, the study sorts portfolios of Swedish stocks into quintiles by downside beta. These portfolios are then evaluated using standard asset pricing models, along with extensions that incorporate low-beta strategies such as the inclusio

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Background Prostate-specific membrane antigen (PSMA)-PET usage in patients with prostate cancer is growing rapidly. Thus, novel risk-group definitions based on PSMA-PET are urgently needed for guidelines, clinical use, and trial study design. We report improved risk classification based on PSMA-PET Prostate Cancer Molecular Imaging Standardized Evaluation (PROMISE; PPP) nomograms (PPP3) to prognos