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The complement system is an essential effector of both innate and acquired immune responses. Due to its destructive potential, tight regulation is required. The contribution of complement has been associated with the pathogeneses in a wide range of diseases. In this thesis, aspects of complement activation were investigated in disorders characterized by thrombocytopenia.In papers I and II, clinicaThe complement system is an essential effector of both innate and acquired immune responses. Due to its destructive potential, tight regulation is required. The contribution of complement has been associated with the pathogeneses in a wide range of diseases. In this thesis, aspects of complement activation were investigated in disorders characterized by thrombocytopenia.In papers I and II, clinica

När bör det vara möjligt att genomföra markåtkomst och hur bör ett sådant system regleras rättsligt? Det är en av de frågor som avhandlingen besvarar.Markåtkomst handlar om vilka möjligheter en aktör har för att inskränka äganderätten till mark. Äganderätt generellt är viktig i samhället, den är nödvändig för att individer ska kunna handla med varandra och en fungerande marknadsekonomi. Mark har sPrivate property rights are a central and important institution in the society. These rights are a prerequisite for individuals to have incentives to invest in their properties, be able to trade with each other, economic growth and more. In some situations, private land ownership may have to be put aside for society to function adequately; since society needs to build housing, infrastructure and o

Hjärtinfarkt är en av de vanligaste anledningarna till för tidig död. Vid en hjärtinfarkt dör delar av hjärtmuskeln på grund av att den utsätts för mycket kraftig syrebrist när ett kranskärl täpps till. Även hjärtmuskelvävnad i infarktens närhet påverkas. Hjärtats vänsterkammare förser kroppen med syresatt blod. Exakt hur vänsterkammarens funktion påverkas under de första dagarna efter hjärtinfark

An experimental and computational study of the near-wall combustion in a Homogeneous Charge Compression Ignition (HCCI) engine has been conducted by applying laser based diagnostic techniques in combination with numerical modeling. Our major intent was to characterize the combustion in the velocity- and thermal boundary layers. The progress of the combustion was studied by using fuel tracer LIF, tAn experimental and computational study of the near-wall combustion in a Homogeneous Charge Compression Ignition (HCCI) engine has been conducted by applying laser based diagnostic techniques in combination with numerical modeling. Our major intent was to characterize the combustion in the velocity- and thermal boundary layers. The progress of the combustion was studied by using fuel tracer LIF, t

[3H]Arachidonic (20:4) and [14C]linoleic acid (18:2) were fed to thoracic duct-cannulated rats in test meals of either tracers alone, cream, Intralipid, pure arachidonic acid, or pure linoleic acid. Less [3H]20:4 than [14C]18:2 was recovered in chyle during the first 5 h. After cream feeding, the proportion of radioactivity found in phospholipids was high and increased during the first 3 h. After [3H]Arachidonic (20:4) and [14C]linoleic acid (18:2) were fed to thoracic duct-cannulated rats in test meals of either tracers alone, cream, Intralipid, pure arachidonic acid, or pure linoleic acid. Less [3H]20:4 than [14C]18:2 was recovered in chyle during the first 5 h. After cream feeding, the proportion of radioactivity found in phospholipids was high and increased during the first 3 h. After

The city of Helsingborg in Sweden has since 2010 been conducting a development work of its social housing programme. The city has built up a Housing First service, which today comprises 60 tenants, and has good results. Through two pilot projects, the city has also tried to develop the other parts of the social housing programme that previously was built on the staircase model. The ambition was toThe city of Helsingborg in Sweden has since 2010 been conducting a development work of its social housing programme. The city has built up a Housing First service, which today comprises 60 tenants, and has good results. Through two pilot projects, the city has also tried to develop the other parts of the social housing programme that previously was built on the staircase model. The ambition was to

Floder och åar är viktiga källor för järn och andra näringsämnen till Östersjön. De senaste decennierna har järnkoncentrationen i svenska och finska åar ökat kraftigt, vilket skulle kunna leda till en ökad transport av järn till Östersjön. Vilken effekt detta kan ha för Östersjön beror på vad som händer med järnet när det möter det salta vattnet i Östersjön. Järn transporteras huvudsakligen i formRivers have traditionally not been considered important sources of bioavailable iron (Fe) to the marine waters, since most Fe is lost by salinity-induced aggregation and sedimentation during estuarine mixing. However, recent studies from boreal rivers found a remarkably high Fe stability, probably due to the interaction with organic matter. Recent studies have suggested that Fe speciation is a key

Combustion, present in a vast majority of energy and material production as well as in transportation, represents a foundation of our modern society. To improve and optimize the applications relying on combustion demand a high level of knowledge, and an ability to simulate the combustion process. To do so three-dimensional Computational Fluid Dynamic (CFD) combustion simulations can be used, whereCombustion, present in a vast majority of energy and material production as well as in transportation, represents a foundation of our modern society. To improve and optimize the applications relying on combustion demand a high level of knowledge, and an ability to simulate the combustion process. To do so three-dimensional Computational Fluid Dynamic (CFD) combustion simulations can be used, where

Cobalt (Co) nanoparticles (NPs) may be diffusely dispersed into natural ecosystems from various anthropogenic sources such as traffic settings and eventually end up in aquatic systems. As environmentally dispersed Co NPs may be transferred through an aquatic food web, this study investigated this transfer from algae (Scendesmus sp.) to zooplankton (Daphnia magna) to fish (Crucian carp, Carassius cCobalt (Co) nanoparticles (NPs) may be diffusely dispersed into natural ecosystems from various anthropogenic sources such as traffic settings and eventually end up in aquatic systems. As environmentally dispersed Co NPs may be transferred through an aquatic food web, this study investigated this transfer from algae (Scendesmus sp.) to zooplankton (Daphnia magna) to fish (Crucian carp, Carassius c

Vi spenderar en tredjedel av våra liv sovandes och sömn är en avgörande faktor för god hälsa och välbefinnande. Men det är även viktigt att erkänna sömnens komplexitet, eftersom det är flera faktorer som kan påverka sömnen. Både biologiska, kontextuella och psykosociala faktorer har inverkan på ungdomarnas sömn. Otillräcklig sömn, sömnproblem och symptom på insomni är vanligt hos ungdomar. SömnlösInsufficient sleep, sleep problems and insomnia are common in adolescents, and insomnia and insufficient sleep are public health concerns that can impact adolescents’ mental and physical health. There are several different treatments for sleep problems and insomnia, and there is a great focus on the problem when it has already arisen. However, since this is a public health problem, it is important

Inom besöksnäringen är delningsekonomins utbredning särskilt tydlig och inom denna industri återfinns en rad företag såsom Airbnb, Vayable, Getmyboat, OffWeFly, EatWith, Uber, Fodora och Travelbuddy. Airbnb, som förmedlar uthyrning av privatpersoners bostäder som en sorts hotellrum, är kanske det mest välkända företaget. Typiskt för delningsekonomin i tjänstesektorn är digitala plattformar som sam

I omställningen till en mer hållbar bioekonomi har mycket fokus legat på utvecklingen av biobränslen. När det gäller innovation och utveckling av kemikalier och andra produkter släpar utvecklingen efter av flera orsaker, vilket visas i denna avhandling.Forskningen visar att det nuvarande systemet är inlåst i ett fossilberoende av flera olika orsaker, både tekniska, organisatoriska och materiella. The transition to a bioeconomy is dependent on transformative changes to technologies, organisations, and institutions, which jointly can be described as a socio-technical change. The thesis contributes to the understanding of how the transition is shaped by expectations on and collaborations for innovation forbiorefineries, which can produce chemicals, fuels, and materials needed in a bioeconomy.

Cementproduktion står idag för en ansenlig andel av världens koldioxidutsläpp, vilket driver utvecklingen av bindemedel med lägre koldioxidutsläpp. För utsläppen i ett längre perspektiv är dock de nya bindemedlens beständighet absolut avgörande. De flesta nedbrytningsmekanismer är direkt relaterade till både fukt- och jontransport. Dessa processer har undersökts i många studier, men huvudsakligen Cement production is responsible for a significant portion of manmade CO2 emissions. This motivates the development of cementitious binders with a lower carbon footprint. Considering the emissions in a longer perspective, the durability of concrete structures is absolutely essential. Most degradation of concrete structures is closely related to both moisture transport and ion transport. Many studi

Syftet med studien är att undersöka det förbättrade upptaget av det radioaktiva spåret Technetium-99m-DTPA (99mTc-DTPA) i råtta Muskelvävnad i Fischer 344 råttor efter applicerade elektriska pulser med olika fältstyrka och pulslängd,Metoder: 99mTc-DTPA (totalt 150 MBq) administrerades intramuskulärt (i.m.) vid axeln som en bolus i flera fraktioner av 50 l vardera i intervaller på 1 minut. Bilder

Tiden är knapp att nå uppsatta klimatmål. För att nå dit krävs kraftfulla åtgärder och styrning. Det står även klart att vi inte når ett hållbart transportsystem med bara någrafå åtgärder – det krävs att en mängd olika åtgärder och styrmedel kombineras och införs. Utöver ökad energieffektivisering, byte av drivmedel och ökade transportkostnader krävs även åtgärder och styrmedel för ett mer transpo

BackgroundStreptococcus pyogenes bacteremia is a severe condition with high mortality. Time to blood culture positivity (TTP) is known to predict the outcome in bacteremia with other pathogens. This study aimed to determine the association between TTP and outcome in S pyogenes bacteremia.MethodsThis retrospective observational cohort study comprised adults with S pyogenes bacteremia, identified thBackgroundStreptococcus pyogenes bacteremia is a severe condition with high mortality. Time to blood culture positivity (TTP) is known to predict the outcome in bacteremia with other pathogens. This study aimed to determine the association between TTP and outcome in S pyogenes bacteremia.MethodsThis retrospective observational cohort study comprised adults with S pyogenes bacteremia, identified th

There are many definitions of resilience, but in general it refers to the ability of a system, which may be a community, society, or economic system that are exposed to extreme disturbances, persistent stress, or hazards to resist, absorb, accommodate, adapt to, transform and recover from effects of the situation in a timely and efficient manner (PreventionWeb n.d.;). Sustainability is focused on

This thesis deals with private international law issues related to the treatment of economic sanctions in international commercial contract disputes in Swedish courts. The dissertation consists of 10 chapters. The first chapter is an introduction. Chapter 10 contains a summary.In Chapter 2, the author examines what economic sanctions are, and in chapter 3, economic sanctions are classified as beloThis thesis deals with private international law issues related to the treatment of economic sanctions in international commercial contract disputes in Swedish courts. The dissertation consists of 10 chapters. The first chapter is an introduction. Chapter 10 contains a summary.In Chapter 2, the author examines what economic sanctions are, and in chapter 3, economic sanctions are classified as belo

Lukas van der Heiden Hotet från havet Klimatförändringarna förväntas i framtiden ge upphov till allt fler klimatrelaterade risker i kustnära områden i Sverige, bland annat i form av havsnivåhöjningar, stormar, översvämningar och erosion. Ett antal personer boende i kustnära områden i Helsingborg samt Helsingborgs kommun har via intervjuer delat med sig av sina uppfattningar, upplevelser och åsikAbstract Helsingborg is one of the coastal municipalities in Sweden that have experienced coastal flooding. This is a risk that may occur more frequently due to the current climate change. The purpose of this study is to examine how residents living near the coast in Helsingborg perceive the risks of climate change, if they have used any measures to protect themselves and their homes from this, a

Data from NASA's Kepler space telescope, which searches for exoplanets via the transit method, produced 1108 new planetary candidates in 2013 with a total of 91% being smaller than Neptune in size. These were mostly super-Earths, terrestial planets between Earth and Neptune in size, with orbits around 10 days. In order for any theory of planet formation to be valid it must be able to account