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Effects of Rho kinase, prostacyclin and L-arginine on microvascular permeability and perfusion

Popular Abstract in Swedish Cirkulationen i de minsta kärlen, de s.k. mikrovaskulära utbyteskärlen är viktig för vävnadens syre- och näringstillförsel. Mikrocirkulationen utgörs av de minsta artärerna, kapillärerna, och de minsta venerna. I kapillärerna och i de minsta venerna sker utbytet av näring, syre, samt koldi-oxid och andra metabola restprodukter. För fettlösliga ämnen som koldioxid och syThis thesis presents some effects of Rho kinase, prostacyclin (PGI2) and nitric oxide (NO) in relation to trauma and inflammation by evaluating their effects on microvascular perfusion and permeability in mouse brain and in cat skeletal muscle. PGI2 and NO are endogenous vasoactive substances produced by the endothelium. They are vasodilators with antiaggregatory/antiadhesive and permeability-redu

Mortality in Oxygen-Dependent Chronic Obstructive Pulmonary Disease and Possibilities for Pharmacological Interventions

Popular Abstract in Swedish Bakgrund Kroniskt obstruktiv lungsjukdom (KOL) är en vanlig orsak till död världen över och dödligheten ökar främst bland kvinnor. Patienter med kronisk syrebrist på grund av KOL behandlas med hemsyrgas (LTOT), men har mycket hög dödlighet. Kunskapen är idag bristfällig kring könsskillnader och tidstrender i dödlighet och dödsorsaker, betydelsen av andra sjukdomar (samsBackground Chronic obstructive pulmonary disease (COPD) is a major and rising cause of mortality worldwide, especially in women. Patients with chronic hypoxia owing to COPD are treated with long-term oxygen therapy (LTOT) but have high morbidity and mortality. Knowledge is limited on sex-related differences and time trends in mortality, effects of comorbidity on mortality and whether cardiovascula

Molecular Mechanisms in Amyloid Disorders. Novel Treatment Options in Hereditary Cystatin C Amyloid Angiopathy.

Popular Abstract in Swedish Ett felaktigt protein som klumpar ihop sig i hjärnans blodkärl är orsaken till hjärnblödning och för tidig död hos unga islänningar. Sjukdomen är ärftlig och uppkommer på grund av en enda felaktig byggsten, orsakad av en mutation, i proteinet cystatin C. Det muterade proteinet bildar mikroskopiska proteinkedjor, fibriller, som klumpar ihop sig i bland annat hjärnans bloThe pathophysiological process in Alzheimer’s disease and other amyloid disorders usually involves the transformation of a soluble monomeric protein via potentially toxic oligomers into amyloid fibrils. The structure and properties of the intermediary oligomers have been difficult to study due to their instability and dynamic equilibrium with smaller and larger species. This has hampered the devel

Riskhantering i en socken

Vårt syfte med detta kapitel är att beskriva och analysera krisförberedande arbeten i en landsortsby från en lokal risk- och sårbarhetsgrupps perspektiv samt tydliggöra olika drivkrafter, förutsättningar och relationer med myndigheter och andra aktörer. Underlaget för kapitlet utgörs av en intervju med representanter för den lokala gruppen i en socken i Kronobergs län, en enskild intervju med en n

Entrepreneurship, Career Experience and Learning - Developing Our Understanding of Entrepreneurship as an Experiential Learning Process

Popular Abstract in Swedish Varför är vissa individer bättre på att identifiera och exploatera nya affärsmöjligheter än andra? Ett antagande som ofta lyfts fram är att framgångsrika entreprenörer förväntas ha utvecklat specifika kunskaper genom tidigare karriärerfarenhet, vilket i sin tur främjar deras entreprenörskap. Om detta antagande stämmer, hur kan vi förstå denna erfarenhetsbaserade lärprocWhy are some individuals more successful in recognizing and exploiting new venture opportunities than others? The common view is that successful entrepreneurs have acquired and developed specific types of knowledge through their previous career experiences, which in turn facilitate their involvement in the entrepreneurial process from opportunity recognition to opportunity exploitation. If this is

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Abstract in Danish Da Fukushima-katastrofen ramte Japan i dagene efter d. 11. marts 2011, forbløffede det medier i resten af verden, hvordan de japanske massemedier valgte at dække den meget alvorlige og eskalerende begivenhed. Mens vestlige nyhedsmedier efterspurgte større åbenhed og mere substans i de sparsomme informationer, de japanske myndigheder og TEPCO offentliggjorde, virkede de japanske

Social sårbarhet utifrån ett medborgarperspektiv.

När extraordinära händelser inträffar, handlar de akuta insatserna för de drabbade om livräddning och akutsjukvård. Annan praktisk hjälp t.ex. att åtgärda vattenförsörjning och återställa infrastruktur ingår i kommunernas och andra myndigheters insatser. Sedan slutet av 1980-talet har även det psykologiska och sociala stödet uppmärksammats. I samband med s.k. Kistaolyckan 1988, då skolelever dog i

Sexual conflict and selection on pistil and pollen traits

Popular Abstract in Swedish Konflikter och sexuellt urval under pollenkonkurrens Naturens många fantastiska färger och former har till stor del skapats av det sexuella urvalet, det vill säga selektionstryck som skapas av konkurrens och val, som uppstår till följd av att djur och växter fortplantar sig. Det var Darwin som 1871 presenterade teorin om det sexuella urvalet i ett försök att förklara vThe incidence of sexual selection in plants is today acknowledged, however, just as in animals, evolution and maintenance of mate choice is gravely underexplored. Moreover, the potential for sexual conflicts to occur in plants has only been assessed empirically to a very limited degree. Using the hermaphroditic annual herb Collinsia heterophylla, I looked deeper into the role of pollen-pollen comp

Consequences of bushmeat hunting in tropical forests

Popular Abstract in English This thesis presents data from rainforests of southeastern Nigeria. Pairs of protected and hunted of study sites were established in three different but adjacent protected areas: 1. Mbe Mountain Community Forest (MMCF, total area 80 km2); 2. Afi Mountain Wildlife Sanctuary (AMWS, total area 100 km2); and 3. Okwangwo division of the Cross River National Park (CRNP), totaThis thesis evaluates the effect of bushmeat hunting in southeastern Nigerian rainforests on: 1) adult tree, seedling, and animal community compositions 2) germination and survival among seedlings in association with competition 3) changes in community composition at multiple trophic levels 4) leaf nitrogen concentration (LNC), leaf mass per area (LMA) and stem specific density (SSD) 5) on human r

Kung Fotboll: Den svenska fotbollens kulturhistoria från 1800-talets slut till 1950

Popular Abstract in Swedish Avhandlingen behandlar den svenska fotbollens kulturhistoria från 1800-talets slut fram till år 1950. Det är berättelsen om hur spelet gradvis etableras, överkommer en mängd inre och yttre problem och konflikter, för att träda in i sin guldålder under 1940-talet. Mer konkret följs hur fotbollens medelklassdominerade maktelit försökte kontrollera skeendet inom en sport pThis thesis concerns Swedish football´s cultural history from the end of the nineteenth century to 1950. It is the story of how the game was gradually established, and overcame a great number of internal and external problems and conflicts, before entering its sporting and cultural golden age during the 1940s. I demonstrate how this game´s middle-class dominated power elite tried to control the de

Absorbed Dose Determination and Characteristics of Degraded Electron Beams: Application to Intraoperative Radiation Therapy

Popular Abstract in Swedish Intraoperativ strålbehandling (IORT) innebär att en hög engångsstråldos ges direkt under operation till den kirurgiskt frilagda tumören och/eller kvarvarande tumörrester. Den vanligaste typen av strålning som används vid denna behandlingsform är elektronstrålning från konventionella medicinska linjäracceleratorer. Det krävs dock att ett speciellt applikatorsystem finns The aim of this work was to quantify limitations of and uncertainties in commonly used dosimetric techniques for relative absorbed dose determination in degraded electron beams, such as those encountered in intraoperative radiation therapy (IORT) and small-electron-field radiotherapy. Three different detector types were investigated with regard to measurements of output factors and relative absorb

Investigation of Kinetically Labile Supramolecu-lar System Addressing Substrate Selectivity in the Catalytic Epoxidations of Olefins

Popular Abstract in Swedish Inom kemin kan uppbyggnaden av molekylära aggregat styras genom att använda sig av kovalenta bindningar eller genom att utnyttja svaga växelverkningar. Den moderna kemin baseras på många års grundforskning på reaktionsförlopp där bildningen av en kovalent bindning stått i fokus vilket har gjort det möjligt att förutsäga utfallet av en sådan reaktion. Däremot är det betyThis thesis is devoted to the development and investigation of a supramolecular system used to catalyze Jacobsen-Katsuki epoxidations with the aim to attain substrate selectivity without product inhibition. The supramolecular catalyst is composed of two well-defined entities or units: a catalytic and a receptor. The keyword for the design was flexibility. The interactions foming the supramolecula

Undervisningens möjligheter att förändra elevernas tänkande inom området aids och sex

How can school influence the viewpoints students hold on aids and sex?The investigation focused on teaching the subject of aids and sex to secondary school students in grades e ght throug eleven. Thirteen teachers and their students, in 15 different c1asses, were studied and compared with a control group; altogether 548 students were included in the investigation.The aim of the study was to determHow can schools influence the viewpoints students hold on aids and sex? The investigation focused on teaching the subject of aids and sex to secondary school students in grades eight through eleven. Thirteen teachers and their students, in 15 different classes, were studied and compared with a control group; altogether 548 students were included in the investigation. The aim of the study was to de

On the Determination of Reactive Compounds in Aerosols

Popular Abstract in Swedish Denna avhandling inom forskarutbildningsämnet arbetsmiljöteknik beskriver nyutvecklade provtagnings- och analysmetoder för att undersöka hur reaktionsbenägna luftföroreningar uppkommer och sprids i arbetsmiljön. Antalet människor som drabbas av allergier har ökat de senaste årtiondena. Många av de mekanismer som ger upphov till allergier och överkänslighetsreaktioner kMany sources of airborne contaminants have always been present in various work environments. With the development of thermosetting plastic systems, the use of reactive chemical compounds was greatly increased and thus also the risk of exposure to reactive and potentially hazardous compounds. Exposure can occur in many situations, not only at the workplace where the raw materials are handled. The f

Cardiac muscle injury in children and experimental animals. Reflections in ECG, especially high-resolution electrocardiography

Popular Abstract in Swedish Bakgrund: Det första elektrokardiogrammet (EKG) utfördes 1887 av Augustus Desiré Waller. Det innebar att spänningsskillnader mellan olika delar av hjärtat, under hjärtats arbete dvs. vid upprepade sammandragningar och avslappningar, kunde registreras med elektroder på kroppens yta. Metoden utvecklades vidare av Willem Einthoven, som fick nobelpriset för sitt arbete 1924Background and Methods: Signal-averaging ECG (SAECG), a bioelectrical processing method, is a further development of the conventional ECG. SAECG can detect voltage potentials in the microvolt range and provide a noise-reduced determination of QRS duration. Extended frequency spectra can be analysed. In adult patients after myocardial infarction it is used to predict the risk for arrhythmias and su

Splitting or synonymizing – genus concept and taxonomy exemplified by the Parmeliaceae in the Nordic region.

The current use of a 30 million year dateline for accepting genera in the Parmeliaceae is evaluated. Its value is doubtful since evolution obviously went quicker in some lichen groups compared with others. Parallel evolution is also very common among lichens. Polyphyletic genera should always be split, while sister groups may remain split or be combined after considering non-molecular characters.

A Social Equity Analysis of Swedish and Scottish National Transport Policy

The topic of social equity in transport planning has been dealt with in particular by authors such as Martens (2012) and Martens and Golob (2012) using a social justice based approach. However, such an approach, whilst valuable and analytically rigorous (based as it is on accessibility modelling), does not consider a wide range of possible other social impacts of transport, as set out in a framewoThe topic of social equity in transport planning has been dealt with in particular by authors such as Martens (2012) and Martens and Golob (2012) using a social justice based approach. However, such an approach, whilst valuable and analytically rigorous (based as it is on accessibility modelling), does not consider a wide range of possible other social impacts of transport, as set out in a framewo

Living with dementia with Lewy bodies: an interpretative phenomenological analysis

Objective: To explore the subjective experience of living with dementia with Lewy bodies (DLB). Design A qualitative study of in-depth interviews using interpretative phenomenological analysis. Setting: A memory clinic in Malmö, southern Sweden. Participants: A purposive sample of five male participants with DLB between the ages of 78 and 88 years and disease duration of 1.5-7 years. Results: ThreObjective To explore the subjective experience of living with dementia with Lewy bodies (DLB).Design A qualitative study of in-depth interviews using interpretative phenomenological analysis.Setting A memory clinic in Malmö, southern Sweden.Participants A purposive sample of five male participants with DLB between the ages of 78 and 88 years and disease duration of 1.5–7 years.Results Three themes

Communicating unknown objects to robots through pointing gestures

Delegating tasks from a human to a robot needs an efficient and easy-to-use communication pipeline between them - especially when inexperienced users are involved. This work presents a robotic system that is able to bridge this communication gap by exploiting 3D sensing for gesture recognition and real-time object segmentation. We visually extract an unknown object indicated by a human through a p

Modeling of nucleation and growth in glass-forming alloys using a combination of classical and phase-field theory

For metallic glasses, it is of vital importance to understand the glass formation properties and to be able to predict the crystallization process in the supercooled liquid. In the present work, we model the process of nucleation and growth using a combination of classical nucleation and phase-field theory. A diffusion coupled phase-field model is used to evaluate the work of formation and the gro