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Background: Heart failure is a disease with high morbidity, mortality, and physical and psychological burden. More knowledge about the care provided for patients with heart failure close to death is needed. Objective: The aim was to describe key aspects of palliative care during the last week of life in patients with heart failure, as reported by healthcare professionals. Design: This is a nationa

This paper discusses the existence and scope of the morality exception from patentability, in Article 53 (a) of the European Patent Convention. The analysis will look into the history of the provision, debate its rational and interpretation by reference to three examples of technology areas: stem cell research; gene editing and AI/big data analytics.Bioscience innovation has always generated heate

The utility of mRNA and protein determinations of G protein-coupled receptor 35, that is, GPR35a (GPR35 V1) and GPR35b (GPR35 V2/3), as indicators of outcome for colon cancer patients after curative surgery was investigated. Expression levels of V1 and V2/3 GPR35, carcinoembryonic antigen and CXCL17 mRNAs were assessed in primary tumours and regional lymph nodes of 121 colon cancer patients (stage

We report ultraviolet-induced transient and stable absorption and two-color holographic recording at 514, 633, and 830 nm in thulium doped stoichiometric LiNbO 3 crystal. The gating light at 355 nm increased the diffraction efficiency and sensitivity. We found the optimum gating-recording intensity ratio for maximum diffraction efficiency and weak nonvolatile holographic storage with gating.

The current war in Ukraine has severely disrupted global food supply chains due to the significant decline in the production of grain commodities, of which Ukraine and Russia are major global suppliers. This creates problems in today’s globalised food systems. In particular, a number of countries are heavily dependent on food imports from Ukraine and/or Russia, particularly some developing nations

Question: What is the interrater agreement of EEG interpretation in adult comatose post cardiac arrest patients using the American Clinical Neurophysiology Society (ACNS) standardized critical care EEG terminology? Methods: The EEG-data were obtained from patients included in the Target Temperature Management trial (TTM), an international, multicenter, clinical trial of temperature management in c

Laser-induced fluorescence (LIF) for quantitative fuel concentration measurements in a combustion engine is a challenging task. Measuring close to the walls of the combustion chamber is even more challenging as both the incident laser light and the signal are strongly reflected on the walls of the combustion chamber. By using a new technique called Structured Laser Illumination Planar Imaging (SLI

BACKGROUND: Acute myocardial infarct (AMI) size depicted by late gadolinium enhancement cardiovascular magnetic resonance (CMR) is increasingly used as an efficacy endpoint in randomized trials comparing AMI therapies. Infarct size is quantified using manual planimetry (MANUAL), visual scoring (VISUAL), or automated techniques using signal-intensity thresholding (AUTO). Although AUTO is considered

Almost thirty years ago the criteria that are currently used to verify claims for the discovery of a new element were set down by the comprehensive work of a Transfermium Working Group, TWG, jointly established by IUPAC and IUPAP. The recent completion of the naming of the 118 elements in the first seven periods of the Periodic Table of the Elements was considered as an opportunity for a review of

Digital technologies have enabled novel forms and reconfigurations of value creation, delivery, and capture. These new reconfigurations challenge the conventional notion of value creation with digital business models. On that premise, the widening of privacy concerns, alert us that organizations of the elite digital, like Netflix, Amazon, and Spotify, design technology to feed on personal data, ba

This paper presents the data and the results of seven fire tests performed on glue laminated timber columns in a compartment built especially for the tests and in which timber wood cribs created a so-called natural fire. These tests are part of a research programme titled "burnout resistance" to establish a new methodology to better describe performance of structural elements during the whole dura

The goal of this study is to identify the perspectives that development NGOs attribute to organisational social media, and furthermore elaborate on an appropriate categorisation of these perspectives for social media use by development NGOs. How social media is used in the area of development, where the use goes far beyond the private sector purpose of publicity and converting a sale, is a key iss

Background: Voluntary self-exclusion from gambling is a common but underdeveloped harm reduction tool in the management of gambling problems or gambling disorders. Large-scale, multi-operator, and operator-independent self-exclusion services are needed. A recent nationwide multi-operator self-exclusion service in Sweden (Spelpaus), involving both land- and web-based gambling sites, is promising, b

Static analysis tools play a crucial role in software development by detecting bugs and vulnerabilities. However, running these tools separately from the code editing process often causes developers to switch contexts, which can reduce productivity. Previous work has shown how Reference Attribute Grammars (RAGs) can be used for declarative implementation of competitive tooling for intraprocedural

Organizations responsible for maintaining critical societal functions must be able to handle both events that can be foreseen and events that come more or less as surprises. Therefore, proactive risk management strategies that build on capacity to adapt to new and unforeseen circumstances must complement strategies that build on the ability to plan for events that can be anticipated on beforehand.

The Adverse Outcome Pathways (AOPs) framework is pivotal in toxicology, but the, terminology describing Key Event Relationships (KERs) varies within AOP guidelines.This study examined the usage of causal, observational and predictive terms in AOP, documentation and their adaptation in AOP development. A literature search and text, analysis of key AOP guidance documents revealed nuanced usage of th

Introduction: Patients with midgut neuroendocrine tumours (NETs) suffer from decreased health-related quality of life (HRQoL), in large part due to bowel symptoms. However, it is unknown which bowel symptoms affect HRQoL the most. An enhanced understanding of this is essential to better focus treatment on this aspect of the disease. This study aimed to determine which bowel symptoms affect HRQoL t

Persons with stress-related disorders, mental disorders and neuropsychiatric disabilities are in particular vulnerable to cognitive challenges at the workplace. The barriers faced by persons with communicative, social and cognitive disabilities are most often invisible to persons in the environment. The objective of the study presented in this paper is to develop and test a tool that increases awa

In all times, societies have known social hierarchies and boundaries between individuals and groups with distinct social characteristics. The extent to which such hierarchies and boundaries are consequential for life outcomes and persist over time differs between societies. These changes over generations in the social structure, and the social, economical, and institutional developments that shape