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Introduction: Accurate and reproducible measures of factor activity are required to guide clinical decision-making following gene therapy for haemophilia B (HB). Highly significant discrepancies have been observed in measurements of various factor IX (FIX) concentrates that carry molecular modifications to extend their half-life, arguing for the need for careful analysis of new HB treatment modali
Energy Management Systems (EMSs) often operate through inflexible, rule-based control systems. Model-free reinforcement learning (RL) has emerged as a promising alternative, providing adaptive and autonomous control without the need for detailed modeling. However, the complexity of operating energy systems and dynamic environmental conditions limits their practical use, with most studies relying o
BACKGROUND: We hypothesized that the main barriers to integrating exercise in routine care of patients with chronic kidney disease (CKD) were structural within European healthcare systems rather than due to resistance among healthcare professionals or patients.MATERIALS AND METHODS: This descriptive cross-sectional study used anonymized questionnaires to investigate nurses' and physicians' attitud
Background: Most multiple sclerosis (MS) patients succumb to a progressive phenotype. Continued lymphocyte activity in the brain, microglia-mediated injury, iron deposition, and oxidative stress are characteristics of progressive MS. Objective: As minocycline and hydroxychloroquine have been shown to inhibit microglia, we evaluated their effects on other outcomes relevant for progression. Methods:
Postmortem MRI allows brain anatomy to be examined at high resolution and to link pathology measures with morphometric measurements. However, automated segmentation methods for brain mapping in postmortem MRI are not well developed, primarily due to limited availability of labeled datasets, and heterogeneity in scanner hardware and acquisition protocols. In this work, we present a high-resolution
To evaluate the feasibility and acceptability of a therapist-guided, mobile app-assisted behavioural treatment for children and adolescents with chronic tic disorders, compared to videoconference-delivered behaviour therapy for tics. Pilot, single-blind, two-arm randomised controlled trial (RCT). A specialist tic disorder clinic for children and adolescents in Denmark. 30 participants with Tourett
Scholte wave surveys were conducted at both the laboratory and field scales to evaluate the reliability of distributed acoustic sensing (DAS) with a fiber-optic cable resting on top of unconsolidated sedimentary deposits to determine the distribution of S-wave velocity underneath. Laboratory measurements performed in a controlled environment at the Deltares Laboratory facility demonstrated that DA
We design a fully polynomial-time approximation scheme for the problem of finding a triangulation of a simple poly-on with a constant number of sources of dilation that achieves the minimum vertex dilation. (c) 2005 Elsevier B.V. All rights reserved.
The inner relative humidity (RH) and degree of saturation (S) of high-performance concrete cured for 2 years in water or 3% NaCl solution were measured at three different levels from the concrete surface (outer layer 0 to 16 mm, middle layer 16 to 32 mm, and inner layer 32 to 50 mm). The effects of many factors, such as water-to-cement (w/c) ratio, content of silica fume, and air content, were inv
Health-health analysis (HHA) focuses on statistical lives themselves as a numeraire. The underlying principle is that the expected gains in health and safety of reduced risks in one area may result in increasing risks somewhere else in society. By reducing one risk other risks may increase due to changed individual behaviour. In addition to this direct effect, another indirect effect will also be
The globular clusters of large spiral galaxies can be divided into two populations: one that formed in situ and one that comprises clusters tidally stripped away from other galaxies. In this paper, we investigate the contribution to the outer globular cluster population in the M31 galaxy through donation of clusters from dwarf galaxies. We test this numerically by comparing the contribution of glo
Objective. To investigate baseline levels of 12 serum biomarkers that constitute a multibiomarker disease activity test, as predictors of response to methotrexate (MTX) in patients with early rheumatoid arthritis (eRA). Methods. In 298 patients from the Swedish Pharmacotherapy (SWEFOT) clinical trial, baseline serum levels of 12 proteins were analyzed for association with disease activity based on
Ischaemic heart disease is the leading cause of death worldwide. The common denominator for plaques causing acute coronary syndrome (ACS) is lipid accumulation, either as a lipid core or lipid pools. An intracoronary imaging device to detect lipid-rich plaques (LRPs) could therefore identify most of the plaques causing ACS and sudden death. Near-infrared spectroscopy combined with intravascular ul
Introduction: Intra-articular glucocorticoid treatment (IAGC) is widely used for symptom relief in arthritis. However, knowledge of factors predicting treatment outcome is limited. The aim of the present study was to identify response predictors of IAGC for knee synovitis in patients with rheumatoid arthritis (RA). Methods: In this study 121 RA patients with synovitis of the knee were treated with
Measurements of normalized differential cross sections for top-quark pair production are presented as a function of the top-quark transverse momentum, and of the mass, transverse momentum, and rapidity of the t (t) over bar system, in proton proton collisions at a center-of-mass energy of root s = 7 TeV. The data set corresponds to an integrated luminosity of 4.6 fb(-1), recorded in 2011 with the
Winter acclimatization in birds is a complex of several strategies based on metabolic adjustment accompanied by long-term management of resources such as fattening. However, wintering birds often maintain fat reserves below their physiological capacity, suggesting a cost involved with excessive levels of reserves. We studied body reserves of roosting great tits in relation to their dominance statu
Cation exchange chromatography has been routinely used for the quantification of monoclonal antibody (mAb) charge heterogeneity. A previously developed method utilizing pH gradients for the elution instead of salt gradients was validated according to current guidelines proposed by the ICH. The linearity, stability, accuracy, precision and the lower limit of quantification have been determined, usi
A sensitive and rapid enzyme-linked immunosorbent assay for simultaneous quantitation of free and IgA-complexed human protein HC was developed with monoclonal murine antibodies. The total amount of protein HC (free plus IgA-complexed) was measured by a competitive procedure while the protein HC-IgA complex was quantitated by a sandwich enzyme immunoassay. The amount of free protein HC was then obt
