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OBJECTIVES: The soluble epoxide hydrolase (gene name EPHX2) is responsible for metabolism of 8,9 11,12 and 14,15-epoxyeicosatrienoic acids, vasodilator and anti-inflammatory substances. There are several functional polymorphisms in the EPHX2 gene: two of them, the K55R and R287Q, showing an altered metabolic activity in vitro, were associated with coronary heart disease and ischemic stroke in prev
INTRODUCTION: Study aim was to find out if patients with Lenke type 1 curve exhibit smaller pedicles and specific pedicle width pattern compared with individuals with no scoliosis. MATERIALS AND METHODS: 4,828 pedicle width measurements (T1-L5) in 61 consecutive patients with adolescent idiopathic scoliosis of Lenke type 1 curve, 61 control subjects, and 20 patients with Lenke type 5 curve, were
Aims: The present study aimed at testing the hypothesis that atrial fibrillatory rate (AFR) is predictive of sinus rhythm maintenance after electrical cardioversion. Methods and results: The study comprised 32 patients admitted for cardioversion of atrial fibrillation of short duration (mean duration 3.8 ± 7.7 days). AFR was estimated using frequency power spectrum analysis of QRST-cancelled ECG.
Medical decision-making is critical and the decisions are made under uncertain, complex, and dynamic conditions. In this regard, practitioners’ experiences and perceptions may provide a bottom-up knowledge of the issues, as well as a corresponding support system that assists them in learning to make decisions in critical situations. The current study aimed to examine these experiences in the Pakis
Objectives: In India, cervical cancer is the most common cancer among women and makes up for up to 29% of all registered cancer in females. Cancer-related pain is one of the major distressing symptoms for all cancer patients. Pain is characterised as somatic or neuropathic, and the total pain experience is often mixed. Conventional opioids are the backbone of analgesic treatment but are most often
AIM: Breath-holding spells (BHS) are common in children, but evidence-based clinical guidelines are lacking. We investigated a large population-based cohort of BHS patients, to propose a refined description of typical BHS and guidelines for its management.METHODS: In a cross-sectional retrospective study, patients diagnosed with BHS in Southern Sweden 2004-2018 were recruited. Disease characterist
Cell replacement therapies for Parkinson's disease (PD) based on transplantation of pluripotent stem cell-derived dopaminergic neurons are now entering clinical trials. Here, we present quality, safety, and efficacy data supporting the first-in-human STEM-PD phase I/IIa clinical trial along with the trial design. The STEM-PD product was manufactured under GMP and quality tested in vitro and in viv
Massive multiple-input multiple-output (MIMO) systems, where the base station (BS) is equipped with a large number of antennas and the mobile devices have a single antenna, can significantly enhance the system performance. In many wireless systems inter symbol interference (ISI) due to delay dispersion of the channel can dramatically affect the demodulation process of the received signals. Precodi
Background: Patients with oesophageal and gastric cancer face a poor prognosis and multiple symptoms and problems that negatively affect their quality of life. In view of the prognosis and extensive illness burden, an early palliative care approach is of importance.Aim: The overall aim of this thesis was to describe and compare symptoms, problems and care needs in relation to the initial treatment
A study of Bc+→J/ψDs+ and Bc+→J/ψDs∗+ decays using 139 fb−1 of integrated luminosity collected with the ATLAS detector from s = 13 TeV pp collisions at the LHC is presented. The ratios of the branching fractions of the two decays to the branching fraction of the Bc+→ J/ψπ+ decay are measured: B(Bc+→J/ψDs+)/B(Bc+→J/ψπ+) = 2.76 ± 0.47 and B(Bc+→J/ψDs∗+)/B(Bc+→J/ψπ+) = 5.33 ± 0.96. The ratio of the b
Hernias are characterized by protrusion of an organ or tissue through its surrounding cavity and often require surgical repair. In this study we identify 65,492 cases for five hernia types in the UK Biobank and perform genome-wide association study scans for these five types and two combined groups. Our results show associated variants in all scans. Inguinal hernia has the most associations and we
Urbanisation drives overall declines in insect pollinators. Although urban green spaces can provide suitable habitat for pollinators much remains to be learned about how urban landscapes either promote or negatively impact pollinators. We investigated how backyard design, local (100 m) and landscape (500 m) scale vegetation cover and human population density were associated with non-eusocial nativ
Research demonstrates that digital technologies stimulate industrial transformation by enabling new interdependencies with firms outside and across firm and industry boundaries. However, we know little about the degree of novelty and breadth of digital technologies that have the potential to transform industries. Understanding the degree of novelty (spanning from radical to incremental) and breadt
The aim of this article is to articulate how legal processes, that produce assumptions about social realities which subsequently shape relations of inequality and oppression, may be explored using a critical legal cartographic approach. Critical cartography points to the duality of representation and construction that is innate to cartography, i.e. when portraying reality, maps are also making it.The aim of this article is to articulate how legal processes, that produce assumptions about social realities which subsequently shape relations of inequality and oppression, may be explored using a critical legal cartographic approach. Critical cartography points to the duality of representation and construction that is innate to cartography, i.e. when portraying reality, maps are also making it.
Cardiometabolic diseases are the leading preventable causes of death in most geographies. The causes, clinical presentations, and pathogenesis of cardiometabolic diseases vary greatly worldwide, as do the resources and strategies needed to prevent and treat them. Therefore, there is no single solution and health care should be optimised, if not to the individual (ie, personalised health care), the
Alla barn har rätt till en grundläggande utbildning. Det är en mänsklig rät-tighet som stadgas i exempelvis barnkonventionen. Forskning visar att sko-lan är en bra skyddsfaktor, en fungerande skolgång minskar risken att hamna i ogynnsamma förhållanden, exempelvis kriminalitet. Barn som är placerade utanför hemmet är en grupp som löper större risk att hamna i ogynnsamma förhållanden, samtidigt som Every child has the right to a primary education. This is a human right stat-ed in documents such as the Convention on the Rights of the Child. Re-search shows that school is a significant protective factor; a functioning school experience reduces the risk of ending up in harmful environments, such as criminality. Children placed outside their homes are a group which are at greater risk of ending
