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In the late stage of Parkinson's disease (PD), there is an increasing disease burden not only for the patients but also for their informal caregivers and the health and social services systems. The aim of this study was to explore experiences of late-stage PD patients' and their informal caregivers' satisfaction with care and support, in order to better understand how they perceive the treatment a
Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) are high-risk factors of diabetes development and may be caused by defective insulin secretion in pancreatic beta-cells. Glucose-stimulated insulin secretion is mediated by voltage-gated Ca2+ (CaV) channels in which the gamma-4 subunit (CaVγ4) is required for the beta-cell to maintain its differentiated state. We here aim to explo
Hematopoietic stem cells (HSC) give rise to all types of blood lineages, including red blood cells (RBC). Hematopoietic stem/progenitor cells (HSPC) are known to be functionally diverse in terms of their self-renewal potential and lineage output. Consequently, investigation of molecular heterogeneity in the differentiation potential of HSPC is vital to identify novel regulators that affect generat
AimOur aim is to provide a-priori information on air-quality implications of potential future energy carriers in transportation relevant for sustainability, life cycle and health-impact assessments.MethodologyInformation on air- and climate-pollutant formation from energy carriers is collected in detailed laboratory assessments on heavy-duty combustion engines as well as on non-tailpipe emissions.
Objective: To investigate whether the first wave of the COVID-19 pandemic impacted healthcare consultations (HCC) and hospitalization among people with and without osteoarthritis (OA).Methods: Using register data, we included individuals aged ≥35 years residing in Skåne region, Sweden, during 2009-2019 with (n = 123,523) and without (n = 552,412) a diagnosis of OA during January 1, 2009-Decemb
Nickel-based superalloys are known to be difficult to machine. These alloys are generally machined with cemented carbide tools under low productivity process conditions. Superhard polycrystalline cubic boron nitride (PcBN) tooling offers the possibility of increased production rates, however, a thorough understanding of the material performance and degradation is required before a transition from
The self-assembly of amyloid β peptide (Aβ) to fibrillar and oligomeric aggregates is linked to Alzheimer’s disease. Aβ binders may serve as inhibitors of aggregation to prevent the generation of neurotoxic species and for the detection of Aβ species. A particular challenge involves finding binders to on-pathway oligomers given their transient nature. Here we construct two phage–display libraries
Despite a large number of studies, out of all drivers of radiative forcing, the effect of aerosols has the largest uncertainty in global climate model radiative forcing estimates. There have been studies of aerosol optical properties in climate models, but the effects of particle number size distribution need a more thorough inspection. We investigated the trends and seasonality of particle number
Optoelectronic devices based on metal halide perovskites continue to show a improved performance, and solution-based coating techniques pave the way for large-area applications. However, not all parameters influencing the thin film formation process of metal halide perovskites are identified and entirely rationalised over their full compositional range, thus hampering optimised thin film fabricati
Rapid-eye movement (REM) sleep behavior disorder (RBD), enactment of dreams during REM sleep, is an early clinical symptom of alpha-synucleinopathies and defines a more severe subtype. The genetic background of RBD and its underlying mechanisms are not well understood. Here, we perform a genome-wide association study of RBD, identifying five RBD risk loci near SNCA, GBA, TMEM175, INPP5F, and SCARB
The high stability and conductivity of 3,4-disubstituted polythiophenes such as poly(3,4-ethylenedioxythiophene) (PEDOT) make them attractive candidates for commercial applications. However, next-generation nanoelectronic devices require novel macromolecular strategies for the pre-cise synthesis of advanced polymer structures as well as their arrangement. In this report, we present a synthetic rou
COSM52_Literature List Mandatory readings: 678 pages Presenter readings: 355 pages Altman, Dennis. "Global gaze/global gays." GLQ: A journal of Lesbian and Gay Studies 3, no. 4 (1997): 417-436. > Pages to read for students: 20 > Available at LUBsearch Ames, Chris. “Crossfire Couples: Marginality and Agency among Okinawan Women in Relationships with U.S. Military Men.” In Over there: Living with
https://www.historiska.lu.se/media/utbildning/dokument/kurser/COSM52/20252/COSM52_literature_list_2025.docx - 2026-05-28
Aims/hypothesis: Genome-wide association studies (GWAS) have identified more than 65 genetic loci associated with risk of type 2 diabetes. However, the contribution of distorted parental transmission of alleles to risk of type 2 diabetes has been mostly unexplored. Our goal was therefore to search for parent-of-origin effects (POE) among type 2 diabetes loci in families. Methods: Families from the
Introduction: The gastro-intestinal hormone glucose-dependent insulinotropic polypeptide (GIP) potentiates glucose-induced insulin secretion, with bone anabolic effects through GIP receptor (GIPR) in animal models. We explore its potential in humans by analyzing association between polymorphisms (SNPs) in the GIP and GIPR genes with bone phenotypes in young and elderly women. Methods: Association
Technical infrastructures of the society are becoming more and more interconnected and interdependent, i.e. the function of an infrastructure influences the function of other infrastructures. Disturbances in one infrastructure therefore often traverse to other dependent infrastructures and possibly even back to the infrastructure where the failure originated. It is becoming increasingly important
Our society is becoming more and more dependent upon the reliable function of a number of vital socio-technical systems. These systems are often being referred to as critical infrastructures, or lifeline systems, indicating their importance for supporting a nation’s economy and social well-being. In the present paper a method is presented for assessing the capability of those actors involved in re
Reliable electrical power supply is a requirement for the modern society, therefore it is important to analyse the vulnerability of the electric power system. Network analysis has previously been used to analyse the vulnerability of electric transmission systems, however recent events in Sweden have shown that perturbations in distribution systems also can cause severe societal consequences. Thus,
Two storms in Sweden 2005 and 2007 clarified both professional crisis managers and citizens' ability to respond to the consequences. These events created an awareness of the vulnerability of society, especially in rural areas. Emergent Citizen Groups (ECG) conducted initially a large part of crisis management, such as clearing roads, supporting exposed neighbors and repairing power lines in collab
We propose a method for identifying and ranking critical components and sets of components in technical infrastructures. Criticality is defined as the vulnerability of the system to failure in a specific component, or set of components. The identification of critical components is increasingly difficult when considering multiple simultaneous failures, especially component failures with synergistic
