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In this work we measured, by using a direct approach, the equilibrium solubility of recombinant Aβ40 peptide to be S = 0.36 ± 0.15 μM in aqueous solution of 20 mM sodium phosphate buffer at pH 7.4. Microfluidic diffusional sizing (MDS) and mass spectrometry (MALDI-TOF/TOF) with isotope standard were used to quantify the concentration of soluble Aβ40 species coexisting with formed fibrils. A
Carpal tunnel syndrome (CTS) is the most common compression neuropathy in the general population and is frequently encountered among individuals with type 1 and 2 diabetes. The reason(s) why a peripheral nerve trunk in individuals with diabetes is more susceptible to nerve compression is still not completely clarified, but both biochemical and structural changes in the peripheral nerve are probabl
Polycystic ovaries (PCO) contain antral follicles that arrest growing around 3–11 mm in diameter, perturbing the dominant follicle’s selection and the subsequent ovulatory process. Proteomic alterations of PCO follicular fluid (FF) (i.e., microenvironment in which the oocyte develops until ovulation) have been studied from large follicles in connection with oocyte pickup during ovarian stimulation
Background & Aims: There is substantial inter-individual variability in the risk of non-alcoholic fatty liver disease (NAFLD). Part of which is explained by insulin resistance (IR) (‘MetComp’) and part by common modifiers of genetic risk (‘GenComp’). We examined how IR on the one hand and genetic risk on the other contribute to the pathogenesis of NAFLD. Methods: We studied 846 individuals: 49
Information processing by traditional, serial electronic processors consumes an ever-increasing part of the global electricity supply. An alternative, highly energy efficient, parallel computing paradigm is network-based biocomputation (NBC). In NBC a given combinatorial problem is encoded into a nanofabricated, modular network. Parallel exploration of the network by a very large number of indepen
Purpose: To describe hand function, and investigate adherence to a rehabilitation protocol and factors associated with upper extremity disability in non-surgically treated proximal phalangeal fractures. Material and methods: In a prospective cohort study, 86 patients (58 women, mean age of 49 years) were assessed at cast removal and 6 weeks follow-up. Adherence was registered in a diary. Factors p
The energy transition of housing is accelerating in parallel with economic inequality reaching historically high levels. There is thus an opportunity to reduce inequalities in living conditions, but also a risk that the costs of the transition are unequally distributed and aggravate existing inequalities. In order to seize the opportunity for a just transition, and in tandem enable a meaningful in
Superconductor-semiconductor hybrid systems play a crucial role in realizing nanoscale quantum devices, including hybrid qubits, Majorana bound states, and Kitaev chains. For such hybrid devices, subgap states play a prominent role in their operation. In this paper, we study these subgap states via Coulomb and tunneling spectroscopy through a superconducting island defined in a semiconductor nanow
In this work, four dyes—consisting of heteroleptic iron N-heterocyclic carbene (NHC) complexes—were investigated in dye-sensitized solar cell (DSC) applications to explore their behavior and interactions with the overall cell. Three of the four dyes contained amino-based electron donor moieties, while one was without this type of structure, and instead had only a hydrogen atom. Compared to earlier
Summary Title: How to make decisions on software based service development in the mobile handset industry. –The Rapid Model for Holistic Application Evaluation Authors: Per-Inge Andersson Patrik Dreveborn Tutors: Björn Regnell, Department of Computer Science, Lund University Robert Wenglén, School of Economics and Management, Lund University Problem formulation: Academically the questions of findi
Countering the effects of human-induced environmental threats around the world is more urgent than ever. At the same time the power of companies has increased in the last decades. Activities of companies are capable of affecting human health negatively and in some cases the effects are so severe as to give rise to human rights violations. The question that is asked in this thesis is whether this p
China is facing multiple challenges of environmental degradation, resource scarcity, and rapid urbanization. The challenges along with people's needs to improve living condition force China to value the importance of developing green buildings. In 2006 the first national green building assessment tool -‐ Evaluation Standard for Green Building (GBS) was released and widely implemented soon aft
The Scanian Economic-Demographic Database (SEDD) has been assembled by the Centre for Economic Demography (CED), Lund University. It contains information about the demographic and economic conditions of people that have lived in 5 parishes in Scania from the 17th century until the present. The SEDD database has been integrated with geographic data, which are digitized from four independent histori
Den här uppsatsen handlar om hur sång kan användas som en språkutvecklande metod i SFI-undervisning. Syftet är att undersöka om det finns fördelar med att använda sång i uttalsundervisning för SFI-studenter samt hur studenterna upplever språkundervisning där musik integreras. Forskningsfrågorna som vi arbetat efter lyder: Vilken effekt har sång i SFI-undervisning på studenternas uttal? Hur uppleveThis study examines how singing can be used as a language development method in second language acquisition for immigrants in Sweden. The aim is to investigate whether there are advantages of using singing when teaching pronunciation to second language students, and how students experience education where music is integrated. Our research questions are: What effect has singing on students’ pronunc
Soils provide the foundation for human well-being but are increasingly degrading from land use change or types of intensive land use like agriculture. In Europe, soil natural capital is degrading over time and space because of compaction, erosion, and the loss of organic matter. This trend diminishes the soil’s ability to sustain a flow of ecosystem services, which are valuable to human well-being
Education for sustainability (EfS) has been regarded a promising approach for solving sustainability challenges. Results have been unsatisfying due to a knowledge-dissemination focus in the formal sector. Reasons are economic and political interests shaping formal education. Therefore, hopes are placed in the non-formal sector to close this knowledge-to-action gap. In this case study, I aim to und
