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Aims: Ischaemic coronary artery disease (CAD) remains the leading cause of mortality globally due to sudden death and heart failure (HF). Invasive coronary angiography (CAG) is the gold standard for evaluating the presence and severity of CAD. Our objective was to assess temporal trends in CAG utilization, patient characteristics, and prognosis in HF patients undergoing CAG at a national level. Me
During 2010-2013, we investigated the effects of stump harvesting on greenhouse gas (GHG) fluxes of carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O) with the flux-gradient technique at four experimental plots in a hemiboreal forest in Sweden. All plots were clear-cut and soil scarified and two of the plots were additionally stump harvested. The two clear-cut plots served as control plot
Remote sensing-based models are an adequate tool to estimate carbon dioxide (CO2) uptake by terrestrial ecosystems, and to upscale the results from ecosystem to regional or global scales. In this study we compare three models driven by Sentinel-2 derived vegetation indices together with eddy covariance (EC) measured CO2 flux and radiation data in order to estimate gross primary production (GPP) in
Vitamin C may impact the efficiency of radiation therapy (RT) in breast cancer. The effects of RT alone or in combination with vitamin C in SKBR3, MDA-MB-231, and MCF7 cells were compared using clonogenic assay, proliferation assay (MTT), cell cycle analysis, and Western blot. Vitamin C use was assessed in 1803 breast cancer patients 2002–2017 in relation to clinicopathological features and recurr
This book considers how the concept of violence has been interpreted, used, defined, and explored by social researchers and thinkers. It does not provide a final answer to the question of what violence is or how it should be explained (or prevented), and instead offers a variety of useful ways of thinking about and theorising the phenomenon, mainly from a sociological standpoint. It outlines four This book considers how the concept of violence has been interpreted, used, defined, and explored by social researchers and thinkers. It does not provide a final answer to the question of what violence is or how it should be explained (or prevented), and instead offers a variety of useful ways of thinking about and theorising the phenomenon, mainly from a sociological standpoint. It outlines four
The global temperature rise is proportional to the cumulative amount of CO2 emissions to the atmosphere. This observation is consistent between climate models and historical observations. It has also given rise to the concept of a carbon budget, which sets a threshold for the amount of CO2 that can be emitted into the atmosphere while still fulfilling political goals such as the Paris Agreement.Te
This study investigates possible structural changes of an intrinsically disordered protein (IDP) when it adsorbs to a solid surface. Experiments on IDPs primarily result in ensemble averages due to their high dynamics. Therefore, molecular dynamics (MD) simulations are crucial for obtaining more detailed information on the atomistic and molecular levels. An evaluation of seven different force
Automated detection of cell nuclei in fluorescence microscopy images is a key task in bioimage analysis. It is essential for most types of microscopy-based high-throughput drug and genomic screening and is often required in smaller scale experiments as well. To develop and evaluate algorithms and neural networks that perform instance or semantic segmentation for detecting nuclei, high quality anno
Nearly 60% of the worlds adult population is projected to be overweight or obese by 2030. The prevalence of obesity- related diseases, such as type 2 diabetes (T2D), has increased markedly in the past decades. The adipose tissue plays an important role in disease progression of T2D. Adipocyte insulin sensitivity, adipose tissue’s ability to expand, and accumulation of subcutaneous rather than visc
Heart failure (HF) is a leading cause of death and disability globally. Heritable factors and the extent and pattern of myocardial fibrosis are important determinants of outcomes in patients with HF. In a genome-wide association study of mortality in HF, we recently identified a genetic polymorphism on chromosome 5q22 associated with HF mortality. Here, we sought to study the mechanisms by which t
Despite low or undetectable plasma viral load, people living with HIV-2 (PLWH2) typically progress toward AIDS. The driving forces behind HIV-2 disease progression and the role of viremia are still not known, but low-level replication in tissues is believed to play a role. To investigate the impact of viremic and aviremic HIV-2 infection on target and bystander cell pathology, we used data-indepen
Background: Although several cardiovascular, demographic, genetic and lifestyle factors have been associated with cognitive function, little is known about what type of cognitive impairment they are associated with. The aim was to examine the associations between different risk factors and future memory and attention/executive functions, and their interaction with APOE genotype. Methods: Participa
Knowledge of human fetal blood development and how it differs from adult blood is highly relevant to our understanding of congenital blood and immune disorders and childhood leukemia, of which the latter can originate in utero. Blood formation occurs in waves that overlap in time and space, adding to heterogeneity, which necessitates single-cell approaches. Here, a combined single-cell immunopheno
In this study we ask how a range of environmental sustainability adjustments that consumers find it easy to adopt affect the carbon footprint of their food consumption. The study is based on information about real purchases offood products and responses to a questionnaire about the various sustainability adjustments that the study participants apply and their concern about climate change. Based onIn this study we ask how a range of environmental sustainability adjustments that consumers find it easy to adopt affect the carbon footprint of their food consumption. The study is based on information about real purchases of food products and responses to a questionnaire about the various sustainability adjustments that the study participants apply and their concern about climate change. Based o
α-Synuclein is an intrinsically disordered presynaptic protein associated with Parkinson's disease. The physiological role of α-Synuclein is not fully understood, but the protein is known to interact with lipid membranes. We here study how membrane charge affects the adsorption of α-Synuclein to (i) supported lipid bilayers and (ii) small unilamellar vesicles with varying amounts of anionic lipids
Mucosa-associated lymphoid tissue protein 1 (MALT1) plays a key role in adaptive immune responses by modulating specific intracellular signalling pathways that control the development and proliferation of both T and B cells. Dysfunction of these pathways is coupled to the progress of highly aggressive lymphoma as well as to potential development of an array of different immune disorders. In contraMucosa-associated lymphoid tissue protein 1 (MALT1) plays a key role in adaptive immune responses by modulating specific intracellular signalling pathways that control the development and proliferation of both T and B cells. Dysfunction of these pathways is coupled to the progress of highly aggressive lymphoma as well as to potential development of an array of different immune disorders. In contra
Bakgrund Muskelaktivering och muskelkraft i quadriceps påverkas av bland annat knävinkeln. Sambandet mellan dessa är inte fastställt. Elektromyografi (EMG) används för att undersöka muskelaktivering och ge information om muskelaktivering och muskeltrötthet. Vridmomentet beräknas genom kraft multiplicerat med hävarm. Syfte Syftet med denna studie var att undersöka aktivering av de ytliga quadriceps
This thesis aimed to explore the binding pocket of galectin-8N and galectin-3C. Both structure-based drug design and fragment-based drug discovery were utilized in this project, exemplifying the benefits of the different approaches. Structural determination of the proteins in complex with both high affinity ligands, and small fragments was achieved through x-ray crystallography. The structures of
Abstract: This thesis is an attempt to evaluate the pre-Christian and Christian and cult-place continuity question. This is done by investigating intervisibility between Christian Churches and pre-Christian grave monuments within the province of Halland, Sweden. This analysis was done via large statistical GIS databases of which viewshed analysis was applied to, which in turn was then interpreted
