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Purpose: Etoposide to standard R-CHOP is used for high-risk diffuse large B-cell lymphoma (DLBCL) in some countries. Due to the lack of randomized trials, a real-world data study using matching methods was used to test the potential effectiveness of R-CHOEP over R-CHOP. Patients and Methods: This study included patients from the Danish Lymphoma Register diagnosed between 2006 and 2020 at the age o
Epigenetic deregulation through altered DNA methylation is a fundamental feature of tumorigenesis, but tumor data from bulk tissue samples contain different proportions of malignant and non-malignant cells that may confound the interpretation of DNA methylation values. The adjustment of DNA methylation data based on tumor purity has been proposed to render both genome-wide and gene-specific analys
Besides thriving on altered glucose metabolism, cancer cells undergo glutaminolysis to meet their energy demands. As the first enzyme in catalyzing glutaminolysis, human kidney-type glutaminase isoform (KGA) is becoming an attractive target for small molecules such as BPTES [bis-2-(5 phenylacetamido-1, 2, 4-thiadiazol-2-yl) ethyl sulfide], although the regulatory mechanism of KGA remains unknown.
Sequential anaerobic/aerobic (A/O) treatment conditions for textile wastewater (WW) are more effective than conventional biological treatment. Anaerobic treatment is essential because anaerobic microbes can first break down complex and recalcitrant compounds, which are difficult to degrade under aerobic conditions. The simpler, more degradable compounds are then further broken down by aerobic micr
Introduction: The scapular osseous free flap (SOFF) is being increasingly used for complex head and neck reconstructions. This study examined the surgical outcomes, focusing on post-operative complications and sequelae in patients who underwent SOFF for maxillary and mandibular reconstructions. Material and Methods: This retrospective, observational, population-based study included patients who un
In this study, a solar dryer incorporating a flat plate heat exchanger to recover heat from exhaust air was investigated to explore the usability of different types of collectors in the system. Their usability was further evaluated through economic and environmental analyses. Moreover, the thermodynamic performance of the solar dryers was evaluated under two weather conditions in Nepal. Apple dryi
Study design: Prospective cohort study. Objectives: To evaluate the effects of wheelchair skills training (WSTR) for participants with spinal cord injury (SCI) during peer-led Active Rehabilitation Camps (ARC) in Poland. We hypothesized that participation in ARC will improve wheelchair skill performance and self-efficacy in individuals with SCI. We also aimed to determine demographic and injury-re
Background: Metabolic-associated steatotic liver disease (MASLD) is a novel term proposed in 2023 to replace non-alcoholic fatty liver disease (NAFLD) with the aim of better reflecting its pathogenesis and clinical manifestations. Vibration-controlled transient elastography (VCTE) is an evidence-based, non-invasive imaging device used to evaluate liver fat deposition and fibrosis. It can effective
ObjectivesThis study aimed to develop and externally validate a model for predicting insufficient future liver remnant (FLR) hypertrophy after portal vein embolization (PVE) based on clinical factors and radiomics of pretreatment computed tomography (CT)Patients and methodsClinical information and CT scans of 241 consecutive patients from three Swedish centers were retrospectively collected. One c
Key recommendationsPastureland restoration must be implemented to reduce dependency oncoping mechanisms such as emergency feeding, mechanized transport andintense workloads. These coping mechanisms are increasingly used to dealwith the cumulative effects of encroachments from competing land uses,predator pressure, and the impacts of climate change on snow conditions.Vigorous thinning of dense, man
Observations of polarization position angle (θ) standards made from 2014 to 2023 with the High Precision Polarimetric Instrument (HIPPI) and other HIPPI-class polarimeters in both hemispheres are used to investigate their variability. Multiband data were first used to thoroughly recalibrate the instrument performance by bench-marking against carefully selected literature data. A novel co-ordinate
Nya skyldigheter för utländska företag verksamma i Sverige infördes den 1 januari 2021. Trots frånvaron av ett fast driftställe i Sverige eller annan skattskyldighet, ska skatteavdrag för preliminär inkomstskatt göras från betalningar för arbete som ett utländskt företag utför i Sverige. Den innehållna skatten kan återbetalas, men tidigast efter att ett beslut om slutlig skatt har fattats efter räNew obligations for foreign companies operating in Sweden have been introduced on 1 January 2021. Despite the absence of a Swedish PE or other tax liability, payments for work performed in Sweden by foreign companies is subject to a requirement of withholding preliminary income tax. A refund of the withheld amount can be granted, but only once a final tax assessment has been completed after the en
Digitaliseringen har medfört svåra utmaningar för det nuvarande skattesystemet. Internationell bolagsbeskattning återspeglar tanken att ett företag måste vara fysiskt närvarande för att leverera varor eller tjänster på en marknad. Nya företagsmodeller möjliggör däremot att kunna nå ut till konsumenter utan någon fysisk närvaro. Det nuvarande internationella skatteregelverket gör det möjligt för boThe digitalisation has posed difficult challenges for the current tax system. International corporate taxation reflects the idea that a company must be physically present to deliver goods or services in a market. However, new business models allow companies to interact with consumers without being physically present. The current international tax regulations allow companies to generate significant
The aim of this study is to decribe social care in homes for elderly mentally frail people and by means of social-philosophical theories identify and analyse these in relation to practical working in social care. The quality study has been possible by the use of interviews with four care-workers and by participant observation. My opinion is that - regarding quality aspects - there isn´t enough tim
The objective of this thesis was to examine what recipients of aid from Swedish Non-Governmental Organizations (NGOs) think about the support and about their possibilities to be independent after the support has been withdrawn. The research questions were: What is the purpose of the aid, from the recipients' point of view? What is the recipients' view of their future as self-supporting and
Syftet med uppsatsen är att ta reda på hur lärare som har blivit mobbade som barn anser att förebyggande mobbningsarbete bör bedrivas. Den undersöker även hur deras utsatthet som barn påverkat deras lärarroll. Undersökningen är gjord genom kvalitativa intervjuer med två lärare och två lärarstudenter. En av slutsatserna är att lärarna påverkats mycket av sin bakgrund vad gäller deras sätt att förhå
Uppsatsen handlar om mobbning och hur detta synliggörs i idrottsföreningar. Ledarna inom idrottsföreningar har intervjuats med en narrativt inspirerad metod för att på så sätt nå deras erfarenheter av hur mobbningen på detta område ser ut. Intervjupersonerna berättar hur de hanterar mobbning personligen och hur detta hanteras inom respektive idrottsförening. Vi lyfter även fram hur ledarna ser på
This literature study shows that Swedish animal husbandry of farm animals is a contributing factor to environmental and climate impact and that both improved knowledge and commitment to environmental issues are important for future sustainable farming out of an environmental standpoint. This literature study is important because it provides a holistic view of how Swedish animal husbandry of farm a
