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BACKGROUND: The standardized test used for evaluating the effect of warfarin is the prothrombin time (PT) which is measured and expressed in international normalized ratio (INR). Regular control of treatment intensity is required since inappropriate dosage increases the risk for complications. Portable point-of-care analytical instruments for measurement of capillary whole blood PT have been avail

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Background and purpose - Avascular necrosis of the femoral head (AVN) is a complication in treatment of developmental dysplasia of the hip (DDH). We evaluated the risk of AVN after early treatment in the von Rosen splint and measured the diameter of the ossific nucleus at 1 year of age. Children and methods - All children born in Malmö, Sweden, undergo clinical screening for neonatal instability o

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Background and purpose Tibial osteotomy by the hemicallotasis technique (HCO) requires strong pin fixation. We compared pin fixation in HCO using a new self-drilling XCaliber pin (Orthofix) with optimized thread and tip design, with the commonly used standard pin (Orthofix). Patients and methods 50 patients, mean age 51 (35-66) years, to be treated by HCO were randomized to standard pins or XCalib

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The possible contribution of HLA-DRB3, -DRB4 and -DRB5 alleles to type 1 diabetes risk and to autoantibodies against insulin (IAA), GAD65 (GADA), IA-2 (IA-2A) or ZnT8 against either of the three amino acid variants, R, W or Q at position 325 (ZnT8RA, ZnT8WA, and ZnT8QA, respectively) at clinical diagnosis is unclear. Next generation sequencing (NGS) was therefore used to determine all DRB alleles

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Scand J Caring Sci; 2011 Individual placement and support - a model to get employed for people with mental illness - the first Swedish report of outcomes Lack of participation in the open labour market is highly prevalent for people with a mental illness across countries, and the proportion of people who get some kind of sickness benefit because of mental illness is steadily growing in Europe. Voc

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We propose a method for dividing large regions into biogeographical sub-regions based mainly on natural disturbance regime, forest history and potential tree species distribution. This subdivision could be used as a guide when designing conservational strategies and management plans for landscapes and protected areas. At present, conservational strategies and management of valuable areas on the on

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This paper examines the assumption that the volume of domestic patenting in Vietnam is too low and needs to be expanded. The structure and state of development of the Vietnamese economy and a set of relevant systems - including the Science and Technology (S&T) System, the Intellectual Property System, the National Innovation System (NIS), and the Science, Technology and Innovation (STI) Policy

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In the present investigation, we sought to refine the classification of urothelial carcinoma by combining information on gene expression, genomic, and gene mutation levels. For these purposes, we performed gene expression analysis of 144 carcinomas, and whole genome array-CGH analysis and mutation analyses of FGFR3, PIK3CA, KRAS, HRAS, NRAS, TP53, CDKN2A, and TSC1 in 103 of these cases. Hierarchic

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Objectives Early detection of neurosensory injury among workers exposed to hand-arm vibration is crucial. The aim of our study was to evaluate the diagnostic test performance of clinical point-of-care testing using a tuning fork and temperature rollers in relation to vibrotactile and thermal quantitative sensory testing. Methods We recruited 225 vibration-exposed workers who underwent clinical poi

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The non-collective and collective high-spin configurations in selected A ∼ 90 (Z = 42-45, N = 46-49) nuclei are analysed within the configuration-dependent shell-correction approach using the cranked Nilsson potential. With this method, various high-spin features, such as shape coexistence, shape changes, band termination and superdeformation are studied along the yrast line. We concentrate on the

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Background Labels for neck pain after a motor vehicle crash (MVC) influenced recovery expectations and management preferences. Research is needed to understand why these expectations and preferences varied based on the label given. Aim To explore how people perceive different labels for neck pain after an MVC. Methods We performed a content analysis of qualitative data from a randomised controlled

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Background: The diagnostic performance of the IOTA methods, the O-RADS lexicon, and the RMI has been validated in prospective and retrospective studies, but most validation studies tested the performance in the hands of experienced ultrasound examiners. Objective: To prospectively validate the performance of the Risk of Malignancy Index, the International Ovarian Tumor Analysis Simple Rules Risk M

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The current novel study aims was to development and characterization of gum based (guar gum: almond gum) composite formulations with or without addition of oregano essential oils to extend the shelf life of okra at ambient condition. In this study, the optimized composite of guar gum: almond gum (75:25 V/V) prepared with addition of different concentrations (0.05, 0.1 and 0.15 % (V/V) of oregano e

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This study explores sustainable energy renovation strategies for a congregation building in southern Sweden using a parametric optimization approach to balance passive and active measures. Passive measures include envelope and window improvements and leakage control, while active measures involve photovoltaic integration and ventilation enhancements. The renovation aims to optimize energy use, the

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BackgroundUmbilical cord arterial pH (UApH) is the most objective measurement of the metabolic condition of the infant at birth. However, studies have identified changes in UApH with advancing gestational age, as there is limited data examining UApH changes with different modes of birth. The objective was to establish reference values for UApH according to mode of birth and to investigate the infl

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A search for the production of three Higgs bosons ((Formula presented)) in the (Formula presented) final state is presented. The search uses (Formula presented) of proton-proton collision data at (Formula presented) collected with the ATLAS detector at the Large Hadron Collider. The analysis targets both nonresonant and resonant production of (Formula presented). The resonant interpretations prima

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Introduction: Flexible Assertive Community Treatment (FACT) is implemented in Swedish general Mental Health Services. While FACT focuses on supporting the participation and personal recovery of individuals with complex mental health needs, critical components enabling these aspects are poorly understood. The aim of this study was to understand the critical components of FACT delivery supporting pa

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Post-translational modifications (PTMs) such as nitration of Tyr (Y) residues and di-tyrosine (DT) formation are known to impact the aggregation behavior of α-synuclein (α-syn), a protein closely linked to Parkinson's disease. Using tetranitromethane (TNM) as a model nitrating agent, we systematically investigated the chemical modifications of α-syn and their consequences for aggregation. Mass spe