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There is an increasing demand for real world evidence. The shift towards relative effectiveness assessment increasingly based on real world data is a natural consequence of the shift towards new adaptive pathways for development and introduction of new medicines in cancer care. The increasing number of alternative treatment options will further increase the need for outcomes data to help optimize
Objective:This post-hoc analysis of the EDGE (Effectiveness of Diabetes control with vildaGliptin and vildagliptin/mEtformin) study assessed inter-regional differences in baseline characteristics and response to treatment intensification with dual oral antidiabetes drugs (OADs) in patients with type 2 diabetes mellitus (T2DM).Methods:Patients with T2DM inadequately controlled with first-line monot
Objective Recently, metabolomics studies have suggested that the neurotransmitter ã-amino butyric acid (GABA) may modulate C. difficile infection (CDI) pathogenesis. In the present study, we investigated the association between GABA-modulating pharmaceuticals and CDI development. Methods In July-December 2013, we performed a matched, retrospective case-control study in Skåne county, Sweden, to ass
This study documents the advancement of laying dates in three species of tits (Paridae) in southernmost Sweden during recent decades, and the absence of a similar response in the pied flycatcher Ficedula hypoleuca. It is based on several different nestbox studies; the oldest one starting in 1969. During 1969 to 2012, mean spring temperatures in the study area increased by between 0.06 and 0.08 °C This study documents the advancement of laying dates in three species of tits (Paridae) in southernmost Sweden during recent decades, and the absence of a similar response in the pied flycatcher Ficedula hypoleuca. It is based on several different nestbox studies; the oldest one starting in 1969. During 1969 to 2012, mean spring temperatures in the study area increased by between 0.06 and 0.08°C p
Enzalutamide significantly improved radiographic progression-free survival (rPFS) and overall survival (OS) among men with chemotherapy-naïve metastatic castration-resistant prostate cancer at the prespecified interim analysis of PREVAIL, a phase 3, double-blind, randomized study. We evaluated the longer-term efficacy and safety of enzalutamide up to the prespecified number of deaths in the final
Nanofiber meshes holds great promise in wound healing applications by mimicking the topography of extracellular matrix, hence providing guidance for crucial cells involved in the regenerative processes. Here we explored the influence of nanofiber alignment on fibroblast behavior in a novel in vitro wound model. The model included electrospun poly-å-caprolactone scaffolds with different nanofiber o
Introduction: CAM2038 q1w (once weekly) and q4w (once monthly) are investigational buprenorphine subcutaneous (SC) formulations based on FluidCrystal® injection depot technology. These two drug products are being developed for opioid dependence treatment, with a target for once-weekly and once-monthly SC dosing. The rationale for developing two products with different dosing frequencies is that tr
Background: Mental health problems among adolescents is a global challenge. During the transition to adolescence, physiological, psychological, and social changes occur, leading to increased vulnerability. Thus, adolescent boys are less likely to seek help for mental health problems, which makes them an undetected group. The aim of this study was to gain a deeper understanding of adolescent boys’
Our current historical moment is marked by a widespread sense of (ongoing and anticipated) crises, prompting calls to change existing economic, political, social, and environmental systems. This discourse has directed increased scholarly and policy-orientated attention to the concepts of “transformation” and “resilience.” However,beyond attention, these concepts have increasingly adopted a place iOur current historical moment is marked by a widespread sense of (ongoing and anticipated) crises, prompting calls to change existing economic, political, social, and environmental systems. This discourse has directed increased scholarly and policy-orientated attention to the concepts of “transformation” and “resilience.” However, beyond attention, these concepts have increasingly adopted a place
Objective To assess the intervention fidelity and explore contextual factors affecting the process of implementing a mobile phone text messaging intervention in improving adherence to and retention in care among adolescents living with HIV, their families and their healthcare providers in southern Ethiopia. Design A convergent mixed-methods design guided by the process evaluation theoretical frame
Aim: To investigate mothers' experience of infant massage. Design: This was an exploratory-descriptive qualitative study based on individual interviews. Methods: A qualitative interview study with an inductive approach was used according to the COREQ guidelines. The participants in the study were mothers (n = 11) residing in Sweden who received training in infant massage from the child health care
Although the information obtained from in vivo proton magnetic resonance spectroscopy (1H MRS) presents a complex-valued spectrum, spectral quantification generally employs linear combination model (LCM) fitting using the real spectrum alone. There is currently no known investigation comparing fit results obtained from LCM fitting over the full complex data versus the real data and how these resulAlthough the information obtained from in vivo proton magnetic resonance spectroscopy (1H MRS) presents a complex-valued spectrum, spectral quantification generally employs linear combination model (LCM) fitting using the real spectrum alone. There is currently no known investigation comparing fit results obtained from LCM fitting over the full complex data versus the real data and how these resul
BACKGROUND AND AIM: In many places worldwide there is an ongoing urbanization, often achieved through densification. An increased number of inhabitants in an area often leads to both increased traffic and placement of new buildings closer to roads, and thus increased population exposure to road traffic noise. The aim of the study was to estimate and compare the health impacts of road traffic noise
Among adolescents, loneliness is common. One kind of loneliness, existential loneliness, is understood as a painful part of the human condition. During adolescence, existential loneliness has been shown to be challenging to navigate independently. Therefore, this study aimed to explore Swedish adolescents’ experiences of existential loneliness regarding receiving and providing support. This study
The possibilities of generative artificial intelligence (GenAI) are both exciting and potentially concerning in many aspects of higher education. One concern may be that the increased use of GenAI tools exacerbates and perpetuates structural inequities due to the material used to train these tools, counteracting efforts to build inclusive learning communities. In this chapter, we consider how univ
Objective: To examine the associations between five major adverse pregnancy outcomes and long term risks of ischemic heart disease in mothers. Design: National cohort study. Setting: Sweden. Participants: All 2 195 266 women with a first singleton delivery in Sweden during 1973-2015. Main outcome measures: The main outcome measure was incidence of ischemic heart disease from delivery to 2018, iden
Background: The period after a child is discharged from hospital is generally described as challenging for the parents. Their satisfaction with the health services received is an important indicator of the quality of care. eHealth devices are increasingly used in health care to support communication with parents. Differences in levels of parental satisfaction by modality of provided care or by par
Adherence to antiretroviral therapy is a global problem among adolescents living with human immunodeficiency viruses (HIV), and it is associated with treatment failure and the development of viral resistance. One of the most significant barriers to treatment adherence among adolescents is forgetting to take drugs as prescribed. One of the key strategies recommended to improve this problem is the u
Collaborative practice among teachers, where teachers collaborate around their teaching practice, is known to optimise student learning in primary and secondary schools, where they are encouraged to create shared conceptions of vision, purpose and means. In higher education, however, studies on teachers working as teams and abandoning traditional norms of isolation and individualism around teachin
BackgroundThe literature on the relationship between anxiety and suicidal behaviors is limited and findings are mixed. This study sought to determine whether physicians noted anxiety symptoms and suicidality in their patients in the weeks and months before suicide.MethodsData were derived from a nationwide medical record review of confirmed suicides in Sweden in 2015. Individuals with at least one
