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Abstract In nature, the coexistence of parasites and hosts has been an important factor in evolution of the immune system, which can be found in all plants and animals. As parasitic infections are by definition affect overall fitness of the host, it is important for the host to be able to counteract the detrimental effects of infections. To ensure this, signaling molecules, known as cytokines, e
Denna studie avsåg att reliabilitetspröva självskattningsinstrumentet VRI-Lund på personer som upplever sig vara röstfriska. VRI-Lund avser att mäta patienters upplevelser av röstbesvär och består av fyra subskalor med tio påståenden i var skala: hals, fysiologisk, emotionell och funktionell samt en egen röstbedömning med Visuell Analog Skala (V AS). Svaren sker genom en skattning på en frekvensba
Glioblastoma multiforme (GBM) is the most common and aggressive brain tumor in adults and is highly resistant to chemo- and radiotherapies. GBM has been associated with alterations in lipid contents, but lipid metabolism reprogramming in tumor cells is not fully elucidated. One of the key hurdles is to localize the lipid species that are correlated with tumor growth and invasion. A better understa
Bayesian inference under a set of priors, called robust Bayesian analysis, allows for estimation of parameters within a model and quantification of epistemic uncertainty in quantities of interest by bounded (or imprecise) probability. Iterative importance sampling can be used to estimate bounds on the quantity of interest by optimizing over the set of priors. A method for iterative importance samp
The rise of animals represents a major but enigmatic event in the evolutionary history of life. In recent years, numerous studies have aimed at understanding the genetic basis of this transition. However, genome comparisons of diverse animal and protist lineages suggest that the appearance of gene families that were previously considered animal specific indeed preceded animals. Animals’ unicellula
Recent evidence suggests that a polyaneuploid cancer cell (PACC) state may play a key role in the adaptation of cancer cells to stressful environments and in promoting therapeutic resistance. The PACC state allows cancer cells to pause cell division and to avoid DNA damage and programmed cell death. Transition to the PACC state may also lead to an increase in the cancer cell’s ability to generate
Therapeutic resistance is one of the main reasons for treatment failure in cancer patients. The polyaneuploid cancer cell (PACC) state has been shown to promote resistance by providing a refuge for cancer cells from the effects of therapy and by helping them adapt to a variety of environmental stressors. This state is the result of aneuploid cancer cells undergoing whole genome doubling and skippi
ZusammenfassungWir beschreiben 10 Empfehlungen für die Entwicklung szientometrischer Visualisierungenund richten uns dabei vor allem an Betreibende szientometrischer Dienste. Die Grundlagedazu bilden Nutzerstudien mit Forschenden verschiedener Disziplinen in Deutschland, welchein einen iterativen Softwareentwicklungsprozess zur Entwicklung einer szientometrischenVisualisierung im Projekt ROSI eingWe describe 10 recommendations for the development of scientometric visualisations and address primarily the operators of scientometric services. The basis for this are user studies with researchers from different disciplines in Germany, who were involved in an iterative software development process for the development of a scientometric visualisation in the ROSI project.
