Filtyp
Nature-based solutions (NBS) can provide a range of benefits to tackle acute sustainability challenges in an enduring and cost-effective manner. Increasing recognition of the value of these solutions has led to their adoption across the globe. However, a majority of NBS projects are implemented with public funding, though the participation of the private sector is vital to achieve comprehensive op
BACKGROUND: The medical programme at Lund University, Sweden, has undergone curricular reform over several stages, which is still ongoing. Students have been somewhat negative in their evaluations of the education during this time. AIM: To find out how the students perceived the educational climate using the Dundee Ready Education Environment Measure (DREEM), and to compare the findings taken at t
The ongoing transition to renewable fuel sources has led to increased use of wood and other biomass fuels. The physiochemical characteristics of biomass combustion derived aerosols depends on appliances, fuel and operation procedures, and particles generated during incomplete combustion are linked to toxicity. Frequent indoor wood burning is related to severe health problems such as negative effec
The Swedish national guidelines for treatment of acute myeloid leukemia (AML) recommend analysis of measurable residual disease (MRD) by multiparameter flow cytometry (MFC) in bone marrow in the routine clinical setting. The Swedish AML registry contains such MRD data in AML patients diagnosed 2011-2019. Of 327 patients with AML (non-APL) with MRD-results reported in complete remission after two c
Russ et al. show that human astrocytes adopt different reactive immune phenotypes when exposed to either TNF-α or alpha-synuclein fibrils, which are exogenous stressors that compete to drive the astrocyte immune reactive response. They also show that PARK2-variant-containing astrocytes exhibit an exacerbated response to the stressors, accompanied by bioenergetic defects.
One organizational innovation introduced by the clean energy for all Europeans package (CEP) is that of the energy community (EC), including the renewable energy community (REC) and citizen energy community (CEC). The translation of related directives into national legislation is underway in Sweden, and the Swedish Energy Market Inspectorate (Ei) has proposed a new law on ECs, which has been sent
Risk analysis is important for safety-critical IT systems and services, both in public and private organizations. However, the actual practices and the challenges of risk analysis in these contexts have not been fully explored. This paper investigates the current practices of risk analysis by an interview-based investigation. This study investigates several factors of the risk analysis process, e.
Mast cells play an important role in asthma, however, the interactions between mast cells, fibroblasts and epithelial cells in idiopathic pulmonary fibrosis (IPF) are less known. The objectives were to investigate the effect of mast cells on fibroblast activity and migration of epithelial cells. Lung fibroblasts from IPF patients and healthy individuals were co-cultured with LAD2 mast cells or sti
Mesenchymal stromal cells (MSC) are ideal candidates for cell therapies, due to their immune-regulatory and regenerative properties. We have previously reported that lung-derived MSC are tissue-resident cells with lung-specific properties compared to bone marrow-derived MSC. Assessing relevant molecular differences between lung-MSC and bone marrow-MSC is important, given that such differences may
BACKGROUND: Clinical stroke trials with stem cell-based approaches aiming for trophic actions, modulation of inflammation and neuroprotection are ongoing. However, experimental studies also suggest that neuronal replacement by grafted neural stem cells (NSCs) and possibly by endogenous NSCs from the subventricular zone (SVZ) may restore function in the stroke-damaged striatum. To evaluate the pote
The current investigation explores the surface effects of quasiatomic layer etching (Q-ALE) of silicon (Si), focusing on the interplay of process parameters, such as Ar+ ion energy, and their impact on etch rate, surface roughness, and material damage. Using a chlorine-based reactive ion etching tool at varying radio frequency bias voltages, the ion energy distribution and etching characteristics
Ribbed channel flows play a crucial role in various engineering systems where turbulence enhancement and improved heat transfer are required, such as in turbine blade cooling and combustor wall applications. Numerical simulations have emerged as an essential tool for analyzing the intricate turbulence dynamics and flow separation phenomena, which are fundamental for optimizing the channel performa
FLT3 is a critical prognostic marker in acute myeloid leukemia (AML) due to its high frequency of mutation. Primary mutations in FLT3 include point mutations or deletions in the tyrosine kinase domain (TKD) and internal tandem duplications (ITD) in the juxtamembrane (JM) region. These mutations lead to ligand-independent activation, disrupting the JM region and kinase domain interaction, resulting
Despite incredible progress in cancer treatment, therapy resistance remains the leading limiting factor for long-term survival. During drug treatment, several genes are transcriptionally upregulated to mediate drug tolerance. Using highly variable genes and pharmacogenomic data for acute myeloid leukemia (AML), we developed a drug sensitivity prediction model for the receptor tyrosine kinase inhib
Developments in sequencing technologies and the sequencing of an ever-increasing number of genomes have revolutionised studies of biodiversity and organismal evolution. This accumulation of data has been paralleled by the creation of numerous public biological databases through which the scientific community can mine the sequences and annotations of genomes, transcriptomes, and proteomes of multip
Biomass residues have been identified as potentially promising resources for production of bio-based products and fuels with low climate impacts. Unlike primary biomass such as crops, using residual biomass may avoid issues such as competition over land for food and feed production. To assess the climate impacts of products made from residual biomass, a life cycle assessment (LCA) may be used, but
This article analyses how urban densification, primarily in relation to ecosystem services, is addressed in comprehensive plans from three cities in southernmost Sweden: Malmö, Lund and Helsingborg. The aim was to investigate and problematise how the comprehensive plans articulate and negotiate how to build dense cities while preserving and enhancing ecosystem services. A qualitative content analy
