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Aquatic organisms are constantly at risk of being exposed to potentially harmful chemical compounds of natural or anthropogenic origin. Biological life can for instance respond to chemical stressors by changes in gene expression, and thus, certain gene transcripts can potentially function as biomarkers, i.e. early warnings, of toxicity and chemical stress. A major challenge for biomarker applicati
Aquaporin-4 (AQP4) is the predominant water channel in the brain; it is enriched in astrocytic foot processes abutting vessels where it is anchored through an interaction with the dystrophin-associated protein (DAP) complex. Enhanced expression with concomitant mislocalization of AQP4 along astrocyte plasma membranes is a hallmark of several neurological conditions. Thus, there is an urgent need t
I min avhandling undersöker jag varierande placering av objekt till verb i svenskans historia. Primärt undersöks placering av nominala objekt visavi negerande adverbial, och sekundärt undersöks placering av nominala objekt visavi andra argument (subjekt och objekt) i huvudsatser. Materialet som ligger till grund för avhandlingen är texter från äldre och yngre fornsvenska (1225-1526), och huvudsaklThis thesis focuses on the distribution of objects in the history of Swedish. The primary focus of the thesis is the distribution of objects relative to negation, and the secondary focus is varying order of nominal arguments in Old Swedish (1225–1526).In Modern Swedish, objects may precede the negation, often referred to as Object Shift, OS, or precede a subject, often referred to as Long Object S
BACKGROUND AND OBJECTIVES: Polymorphic molecules expressed on the surface of certain blood cells are traditionally categorized as blood groups and human platelet or neutrophil antigens. CD36 is widely considered a platelet antigen (Nak a ) and anti-CD36 can cause foetal/neonatal alloimmune thrombocytopenia (FNAIT) in CD36-negative pregnant women. CD36 is used as a marker of differentiation in ear
Objective: Drug eluting stents (DES) might improve the results of stenting in the femoropopliteal (FP) segment, but randomized data between DES and BMS in the treatment of patients with chronic limb threatening ischemia (CLTI) is lacking. The aim of this study was to perform a randomized comparison, between DES and bare metal stent (BMS) implantation in a subgroup of CLTI patients with lesions in
Background: Smartwatches are commonly capable to record a lead-I-like electrocardiogram (ECG) and perform a photoplethysmography (PPG)-based atrial fibrillation (AF) detection. Wearable technologies repeatedly face the challenge of frequent premature beats, particularly in target populations for screening of AF. Objective: To investigate the potential diagnostic benefit of six-lead ECG compared to
Objective: To make a cross-cultural comparison of the contents of rehabilitation goals of patients admitted for rehabilitation and to compare the contents with the comprehensive International Classification of Functioning, Disability and Health (ICF) Core Set for rheumatoid arthritis, by linking their contents to the ICF. Patients: A random sample of 80 patients with rheumatoid arthritis was retri
Disaster risk management has seen the importance of coordination at various levels of planning and implementation, ranging from preparedness to disaster response, and in planning for long term recovery and sustainable development. This thesis aims to develop a deeper and analytical understanding of stakeholder coordination for disaster recovery. The thesis is built on case studies from the mega –d
Förbudet mot köp av sexuella tjänster har varit i kraft i 16 år. Den debatt som åtföljt lagstiftningsarbetet kan dock sägas ha pågått under närmare 40 år. Det är en debatt med starka ideologiska förtecken och det är tydligt att prostitution är en fråga som inte lämnar någon oberörd. Uppsatsens syfte är utreda vilka ideologiska värderingar och skyddsintressen som återfinns i lagstiftarens syn på p
Abstract In nature, the coexistence of parasites and hosts has been an important factor in evolution of the immune system, which can be found in all plants and animals. As parasitic infections are by definition affect overall fitness of the host, it is important for the host to be able to counteract the detrimental effects of infections. To ensure this, signaling molecules, known as cytokines, e
Welding fumes were recently classified as carcinogenic to humans and worldwide millions work as welders or perform welding operations. The purpose of this study was to identify new biomarkers of welding-induced carcinogenesis. We evaluated a panel of 91 putative cancer-related proteins in serum in a cohort of welders working with mild steel (n = 77) and controls (n = 94) from southern Sweden sampl
Here, we describe the generation of an induced pluripotent stem cell (iPSC) line, from a male patient diagnosed with Parkinson's disease (PD). The patient carries a heterozygous variation p.A53T in the SNCA gene. Skin fibroblasts were reprogrammed using the non-integrating Sendai virus technology to deliver OCT3/4, SOX2, c-MYC and KLF4 factors. The generated iPSC line (CSC-32) preserved the mutati
BackgroundResting pulse is robustly and inversely associated with the risk for externalizing disorders and may be positively associated with internalizing disorders. We know little about the causal nature of these associations.MethodsWe examined resting pulse at conscription examination in 369 301 males born 1960-80 with a mean (s.d.) follow-up of 29.1 (7.7) years. From pulse rates, we predicted,
Almost all countries in the world are party to the Rio Conventions. This entails a number of responsibilities, including reporting periodically on aspects of environmental health and national implementation of the convention. These reports can cover hundreds of pages, so completing reports is often a significant undertaking. Since countries can be party to numerous Multilateral Environmental Agree
Educational reforms including community-based educational initiatives maintain crucial roles in the processes of democratization in the Middle East. The patterns of reform are diverse and reflect domestic factors as well as varying linkages to global forces. Among the factors driving and defining the effects of reform we find: 1. Socio-economic development;2. Growth of the civil society;3. New modEducational reforms including community-based educational initiatives maintain crucial roles in the processes of democratization in the Middle East. The patterns of reform are diverse and reflect domestic factors as well as varying linkages to global forces. Among the factors driving and defining the effects of reform we find: 1. Socio-economic development;2. Growth of the civil society;3. New mod
Introduction Chronic breathlessness is highly prevalent and distressing to patients and families. No medication is registered for its symptomatic reduction. The strongest evidence is for regular, low-dose, extended-release (ER) oral morphine. A recent large phase III study suggests the subgroup most likely to benefit have chronic obstructive pulmonary disease (COPD) and modified Medical Research C
