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Oxidative stress plays a role in the onset and progression of a number of diseases, such as Alzheimer’s disease, diabetes and cancer, as well as ageing. Oxidative stress is caused by an increased production of reactive oxygen species and reduced antioxidant activity, resulting in the oxidation of glutathione. The ratio of reduced to oxidised glutathione is often used as a marker of the redox state
This dissertation explores the public library’s democratic and popular educational role in a time when knowledge- and cultural institutions are affected by changes related to digitalisation. The purpose of the study is to examine how library activities, which in various ways are intended to increase individuals’ digital skills, information literacy and participation in society can be understood an
The antimicrobial effects of Laponite nanoparticles with or without loading of the antimicrobial peptide LL-37 was investigated along with their membrane interactions. The study combines data from ellipsometry, circular dichroism, fluorescence spectroscopy, particle size/ζ potential measurements, and confocal microscopy. As a result of the net negative charge of Laponite, loading of net positively
We present a case of a patient in a severe pulmonary mucormycosis during the neutropenic phase of treatment for acute myeloblastic leukaemia (AML), type M2. He had two major risk factors for setting infection; leukaemia and diabetes mellitus. Although he received antimicrobial and antifungal therapy with Amphotericin B in time, it was unable to eradicate infection. We performed a pneumectomy, whic
A program to simulate the production of heavy quarks through the boson-gluon fusion process in e±p collisions is presented. The full electroweak structure of the electron-gluon interaction is taken into account as well as the masses of the produced heavy quarks. Higher order QCD radiation is treated using initial and final state parton showers, and hadronization is performed using the Lund string
The Monte Carlo generator MAJOR 1.5 simulates the production and decay of heavy Majorana neutrinos via lepton mixing or exchange of 'light' right-handed W-bosons in deep inelastic scattering, i.e. e±p → NX → e±W∓X or veZX. Physics and programming aspects are described in this manual.
Spiral wound modules are the most common modules in the industry due to their low investment and replacement costs plus high packing density. The use of spiral wound modules is often restricted to feed streams with a low temperature (< 75°C) and a low viscosity. The focus of this paper is on a new generation of spiral wound modules, which has been introduced by Alfa Laval Membrane Technology for
Membrane fouling is a constant challenge of membrane processes in separation and purification of organic, biomass originated compounds in food, biorefining and biotechnology industries. It persists due to the complexity and high fouling tendency of the bio-based streams and may result in a decrease of filtration capacity, rejection alteration, reduction of membrane lifetime and increase of operati
A method for the fractionation of aerosol particles with respect to size and ability to grow with an increased relative humidity has been developed. The system consists of cascade impactors, diffusion driers, a humidifier and a temperature stabiliser. Diffusion driers were designed and the vapour penetration was modelled below 20%. A humidifier which can be operated with an output relative humidit
This paper is the first part of a program to deal with the relative importance of the different effects in a colour dipole field when the field energy is transformed into hadrons according to a statistical scheme with the sole constraints coming from energy and momentum conservation and the requirements of scaling. In this paper we treat the meson distributions from quark fragmentation with partic
The recent surge in publications on the history of knowledge may obscure the fact that there are several parallel understandings of what the field is. In this article, I discern five major historiographical directions in contemporary scholarship regarding the history of knowledge. The analytical framework that has so far attracted the most attention is the circulation of knowledge. As productive a
During the last decades, methods for intuitive task level robot programming have become a fundamental point of interest for industrial applications. A robot programming framework is needed to facilitate task-level programming of mobile manipulators, e.g. by providing the robot with a set of movement primitives and skills. Robot skills have already been used and tested successfully within the FP7 p
The ambition to integrate disaster risk information from multiple stakeholders exists at different scales in any country and serve to control the risk of losses within companies, organizations and countries as a whole. Against the backdrop of extensive deliberations with risk management professionals in Sweden, this paper is based on an interdisciplinary scoping study of literature aimed to enhanc
Antimicrobial resistance has reached alarming levels in many countries, thus leading to a search for new classes of antibiotics, such as antimicrobial peptides whose activity is exerted by interacting specifically with the microorganism membrane. In this study, we investigate the molecular-level mechanism of action for Labaditin (Lo), a 10-amino acid residue cyclic peptide from Jatropha multifida
Inflammasomes are cytosolic multiprotein complexes that sense microbial infection and trigger cytokine production and cell death. However, the molecular components of inflammasomes and what they sense remain poorly defined. Here we demonstrate that 35 amino acids of the carboxyl terminus of flagellin triggered inflammasome activation in the absence of bacterial contaminants or secretion systems. T
The slow global response to the Ebola crisis in west Africa suggests that important gaps exist in donor financing for key global functions, such as support for health research and development for diseases of poverty and strengthening of outbreak preparedness. In this Health Policy, we use the International Development Statistics databases to quantify donor support for such functions. We classify d
Septate and tight junctions are thought to seal neighboring cells together and to function as barriers between epithelial cells. We have characterized a novel member of the neurexin family, Neurexin IV (NRX), which is localized to septate junctions (SJs) of epithelial and glial cells. NRX is a transmembrane protein with a cytoplasmic domain homologous to glycophorin C, a protein required for ancho
