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Science originates knowledge and downstream innovation. “Big” science is likely to, along the line, give rise to “big” innovation. Large research infrastructures are characterized by containing a large number of partners involved in complex networks of internal and external collaborations. This chapter explores how large research infrastructures (broadly defined) manage internally and externally t
Almost thirty years ago the criteria that are currently used to verify claims for the discovery of a new element were set down by the comprehensive work of a Transfermium Working Group, TWG, jointly established by IUPAC and IUPAP. The recent completion of the naming of the 118 elements in the first seven periods of the Periodic Table of the Elements was considered as an opportunity for a review of
Dynamic glucose-enhanced (DGE) imaging uses chemical exchange saturation transfer magnetic resonance imaging to retrieve information about the microcirculation using infusion of a natural sugar (D-glucose). However, this new approach is not yet well understood with respect to the dynamic tissue response. DGE time curves for arteries, normal brain tissue, and cerebrospinal fluid (CSF) were analyzed
Mutations in the glucocerebrosidase (GBA) gene have been associated with the development of Parkinson's disease (PD). An induced pluripotent stem cell (iPSC) line was generated from a 60-year old patient diagnosed with PD and carrying a new mutation variant p.R301C in GBA. Using non-integrating Sendai virus-based technology, we utilized OCT3/4, SOX2, c-MYC and KLF4 transcription factors to reprogr
This paper presents and assesses the cooling integration of medium size electrical machines with distributed hair-pin type of windings. By introducing a hollow or profiled conductor the generated heat can be removed right where it is created. The cooling duct in conductor that can be connected either to series or parallel cooling flows increases DC resistance up to 1.5 times when comparing commerc
The international development community is transitioning from the era of the Millennium Development Goals (MDGs), ending in 2015, to the era of the Sustainable Development Goals (SDGs), which have a 2030 target. Global development assistance for health (DAH) increased substantially in the MDGs era, from US $10.8 billion in 2001 to $28.1 billion by 2012 (in 2010 US dollars), and it played a crucial
ATT PLÖJA MYCKET, LITE ELLER INGET ALLS Vi blir fler och fler människor på vår planet, och år 2050 beräknas vi vara så många som 10 miljarder. Det innebär att vi måste kunna producera mer mat på en lika stor eller till och med mindre yta jämfört med idag. En stor del av den mat vi konsumerar produceras antingen direkt eller indirekt på åkrar runt om i världen. För lantbrukare som är inriktade på vSoil microorganisms are important for climate regulation as well as for plant nutrition. In agricultural soils the microorganisms are affected by management choices, like which type of tillage that is used. Moldboard plowing, the most common tillage practice, increases mineralization which leads to soil organic carbon (SOC) loss, and may thus reduce soil quality. Conservation tillage practices inf
This paper presents an acoustofluidic chip for the sorting of bacteria from protozoa in water using standing acoustic waves. The size-based acoustophoretic sorting method provides a means for sample pre-concentration, which is vital for real-time, on-site monitoring of drinking water quality and preventing outbreak of waterborne diseases. In practice, high throughput and high recovery pre-concentr
Many lines of evidence suggest that the Parkinson’s disease (PD)-related protein α-synuclein (α-SYN) can propagate from cell to cell in a prion-like manner. However, the cellular mechanisms behind the spreading remain elusive. Here, we show that human astrocytes derived from embryonic stem cells actively transfer aggregated α-SYN to nearby astrocytes via direct contact and tunneling nanotubes (TNT
This paper examines whether or not specific forms of adaptation governance that involve city administrations and citizens can help (or hinder) creating a foundation for more sustainable climate adaptation and transformation. Based on the analysis of recurring patterns of social adaptation dilemmas (caused by the interdependencies between adaptation providers and beneficiaries), associated actor co
Purpose: The knowledge about young adults who have lost a parent to cancer is limited, and to reach a broader understanding about this group, this study used the Dual Process Model of Coping with Bereavement (Stroebe and Schut, 1999) as a theoretical framework. The purpose of this study was to describe loss- and restoration-oriented bereavement stressors and psychosocial wellbeing of young adults
Nursing homes are often places where older persons “come to die.” Despite this, death and dying are seldom articulated or talked about. The aim of this study was to explore assistant nurses’ experiences of conversations about death and dying with nursing home residents. This study is part of an implementation project through a knowledge-based educational intervention based on palliative care princ
We have developed an assay, based on nanofluidic channels and fluorescence microscopy, for optical mapping of DNA based on competitive binding between two molecules - one fluorescent and one sequence selective. From the experimental data we can extract binding constants for the two competing DNA binders, which may be subsequently used to calculate a theoretical reference map of any DNA with known
Klimatförändringarna kommer att påverka ekosystem och samhällen över hela världen. Det är ett problem som kräver drastiska och omedelbara förändringar av vårt sätt att leva och av våra samhällsstrukturer, och därmed politiskt engagemang av aldrig tidigare skådat slag. Under de senaste 30 åren, sedan bildandet av Förenta Nationernas ramkonvention om klimatförändringar (Klimatkonventionen; UNFCCC) åThe rise of climate change as an issue of global concern has rested on scientific representation and understanding of the causes and impacts of, and responses to climatic change. The Intergovernmental Panel on Climate Change (IPCC), in particular, has been central to how climate change has become known as a global political problem. This thesis aims to critically examine the production, negotiatio
Targeted temperature management (TTM) of 32-34 °C has been the standard treatment for out-of-hospital cardiac arrest since clinical trials in 2002 showed benefits to survival and neurological outcome. Recently, this treatment has been challenged by another clinical trial showing no difference in outcome between TTM of 33 °C and 36 °C. This protocol describes the methodology for a meta-analysis det
Short leukocyte telomere length (LTL) may be associated with several psychiatric disorders, including major depressive disorder (MDD). Short LTL has previously been associated with poor response to psychiatric medications in bipolar disorder and schizophrenia, but no studies have prospectively assessed the relationship of LTL to SSRI response in MDD. We assessed pre-treatment LTL, depression sever
Using Deterministic Lateral Displacement (DLD), we are able to separate bacteria by their size and their chain length. This separation enables the study of these properties as factors of virulence.
This study aims to explore how physicians make sense of and give meaning to their decision-making during obstetric emergencies. Childbirth is considered safe in the wealthiest parts of the world. However, variations in both intervention rates and delivery outcomes have been found between countries and between maternity units of the same country. Interventions can prevent neonatal and maternal morb
The ATLAS experiment at the Large Hadron Collider has a broad physics programme ranging from precision measurements to direct searches for new particles and new interactions, requiring ever larger and ever more accurate datasets of simulated Monte Carlo events. Detector simulation with Geant4 is accurate but requires significant CPU resources. Over the past decade, ATLAS has developed and utilized
