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The formation of biomolecular condensates inside cells often involve intrinsically disordered proteins (IDPs), and several of these IDPs are also capable of forming dropletlike dense assemblies on their own, through liquid-liquid phase separation. When modeling thermodynamic phase changes, it is well known that finite-size scaling analysis can be a valuable tool. However, to our knowledge, this ap
Decreasing floral resources as a result of habitat loss is one of the key factors in the decline of pollinating insects worldwide. Understanding which plants pollinators use is vital to inform the provision of appropriate floral resources to help prevent pollinator loss. Using a globally important pollinator, the honeybee, we show how changes in agricultural intensification, crop use and the sprea
We use Markov state models (MSMs) to analyze the dynamics of a β-hairpin-forming peptide in Monte Carlo (MC) simulations with interacting protein crowders, for two different types of crowder proteins [bovine pancreatic trypsin inhibitor (BPTI) and GB1]. In these systems, at the temperature used, the peptide can be folded or unfolded and bound or unbound to crowder molecules. Four or five major fre
Time-dependent ensemble averages, i.e., trajectory-based averages of some observable, are of importance in many fields of science. A crucial objective when interpreting such data is to fit these averages (for instance, squared displacements) with a function and extract parameters (such as diffusion constants). A commonly overlooked challenge in such function fitting procedures is that fluctuations
Risk and vulnerability assessments (RVA) are vital components of the work conducted by public agencies at different levels, as part of the processes for governing and managing risks in the society. In Sweden, public agencies at all levels are required by legislation to perform risk and vulnerability assessments within their respective area of responsibility. The present paper presents a study of h
This reflection, based on a keynote address to celebrate the fortieth anniversary of Disasters on 14 September 2017, begins by considering some of the prevailing assumptions that existed at the time of the journal's creation. Next is a summary of significant milestones during the past 40 years, covering major global trends, changing disaster impacts, and key developments in disaster risk managemen
By using an integrated dynamic model we are able to reconstruct the supply and gold price of the past (1920-2010) and this is used to predict the future supply of gold to the market and to make a forecast of the goldprice 2010-2100. The model was validated against field data for the period 1920-2010 and it performs well. The model GOLD is implemented in the STELLA® software and the model described
The growing interest in sustainable development indicators (SDI) has resulted in the development and application of various SDI frameworks in the past two decades. Identification and selection of “right” indicators with such frameworks are essential, in the sense that, it is the information from these indicators that will help policy and decision makers to better understand the efficiency, effecti
A kinetic model of the fermentative production of lactic acid from glucose by Lactococcus lactis ssp. lactis ATCC 19435 in whole-wheat flour has been developed. The model consists of terms for substrate and product inhibition as well as for the influence of pH and temperature. Experimental data from fermentation experiments under different physical conditions were used to fit and verify the model.
Within a UN Joint Programme titled “Enhancing the Capacity of Turkey to Adapt to Climate Change” a systems approach workshop was carried out in Adana, Turkey with broad stakeholder participation. The participants applied systems thinking approach, causal loop diagramming methodology and systems analysis to examine the potential impacts of projected climatic changes on natural ecosystems and socio-
In this paper we show that several metals, elements and energy resources are about to run into scarcity within the next decades, and most elements within some centuries. A new global systems model was assembled to analyse this scarcity as a continuation of the model used in the Limits-to-Growth World3 model. We show that this scarcity will lead to “peak wealth”, “peak population”, “peak costs”, “p
This paper provides a systemic analysis of complex dynamic issues associated with resource use, scarcity and efficiency by applying systems thinking with respect to sustainability criteria. Casual loop diagramming methodology is adopted to create a conceptual model to better understand the interconnected patterns, cause effect relations and feedbacks between the three dynamic complex systems that
Popular Abstract in Swedish Denna avhandling fokuserar på två av de många faktorer som är av fundamental betydelse både för människors välfärd och för ett lands utveckling dvs. val av dricksvattenkälla och toalettfacilitet. I avhandlingen analyseras olika aspekter av hushållsefterfrågan på dessa två faktorer med hjälp av data från Filippinerna och Bangladesh. Avhandlingen består av fem kapitel, etThis thesis focuses on different aspects of household demand, and the determinants of demand, for water and sanitation related inputs fundamental to the households' well-being, i.e. drinking water and toilet facilities. The thesis consists of five chapters, one introductory chapter and four self-contained, essentially empirical, studies. In chapter two, Women's Health Choices and the Effects on C
This chapter describes the basic principles inside the VEG extension to the ForSAFE model system. It allows changes in ground vegetation to be calculated, an important part of biodiversity. In the VEG model, the basis for modelling ground vegetation dynamics is a competition strength model based on soil chemistry promoting and retarding factors, nutrients, water and light. The strength is used in
Training and exercises programmes are not independent activities, forming part of a larger, risk-based, process of disaster management preparedness. In order to have an impact on an individual's skills knowledge or behaviours, or to influence organizational learning or procedures, the programmes needs a cyclic and holistic approach. It should focus on clearly identified outcomes that are designed
This paper introduces the concept of 'dynamic capability' (DC) in relation to disaster management - in particular to disaster management exercises (DME). Firstly this paper discusses changes and challenges in DME and the concept of dynamic capabilities as one potential approach dealing with the existing challenges in DME. Thereafter it outlines basic contents of developing DC in DME. The paper con
