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BACKGROUND AND OBJECTIVES: Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by 3 core symptom complexes: parkinsonism, cerebellar syndrome, and dysautonomia. Recent Movement Disorder Society (MDS) criteria allow for the clinical diagnosis of MSA based solely on motor symptoms, without requiring dysautonomia. This study aimed to evaluate the frequency and disease trajecto
BACKGROUND: Patients receiving intraoperative ventilation during general anesthesia often have low end-tidal CO2 (etCO2). We examined the association of intraoperative etCO2 levels with the occurrence of postoperative pulmonary complications (PPCs) in a conveniently-sized international, prospective study named 'Local ASsessment of Ventilatory management during General Anesthesia for Surgery' (LAS
INTRODUCTION: Parents can act as important agents of change and support for healthy childhood growth and development. Studies have found that parents may not be able to accurately perceive their child's weight status. The purpose of this study was to measure parental perceptions of their child's weight status and to identify predictors of potential parental misperceptions.METHODS: We used data fro
Infections caused by anaerobes are common in children. However, limited data are available on bloodstream infections caused by these bacteria in Europe. A multicentre retrospective observational study was conducted over a 4-year period (2020–2023) across 44 European hospitals to analyze all anaerobes isolated from blood cultures. The study examined the epidemiology and antimicrobial resistance pro
BACKGROUND: A significant proportion of acute myocardial infarction (AMI) patients have characteristics of high-bleeding -risk (HBR). Their influence on ischaemic and bleeding-events in AMI all-comers is not well described.METHODS: AMI Patients in England and Wales (E&W), and Sweden between 2005 and 2019 were included from MINAP and SWEDEHEART national registries. Patients were categorised acc
CVD (chemical vapor deposition) coated cutting tools typically exhibit thermal cracks caused by the mismatch in coefficients of thermal expansion (CTEs) between coating and cemented carbide. These cracks act as weak points during stainless steel machining, contributing to premature tool wear. As a strategy to suppress thermal cracks formation, we investigate replacing the conventional cemented car
Introduction: Consensus is lacking regarding the upper limit for a safe contraction frequency during labor. We aimed to assess the association between different contraction frequencies and acidemia at birth, and whether an association was affected by oxytocin augmentation, concomitant cardiotocography (CTG) classification, and stage of labor. Material and Methods: This is a case–control study base
Time constants in spiking neural networks (SNNs) are crucial for determining performance. While prior work shows that learning time constants can improve accuracy, it typically assumes near-optimal initial values and rarely examines recovery from poor initializations. We systematically study how membrane and synaptic time constants affect SNN performance using multiple training strategies. Our res
OBJECTIVES: We assessed the prevalence of neurodevelopmental disabilities (NDDs; cognition, cerebral palsy, vision/hearing, epilepsy), attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), developmental coordination disorder (DCD), behavior problems, and multimorbidity in a national cohort of children born extremely preterm (EPT, <27-week gestation) to provide a comprehe
1 Kursanalys för GEOC08, Förorenad mark (15 hp), VT-20, Geologiska institutionen, Lunds universitet I frågeenkäten till studenterna ingick tolv frågor som redovisades i en sammanställning nedan. Sammanfattningsvis tyckte studenterna att kursen var bra, men det finns också en del synpunkter på kursens innehåll och upplägg. Åtets kurs har påverkats kraftigt av Covid-19 pandemin. Trots det upplevde s
https://www.geologi.lu.se/sites/geologi.lu.se/files/geoc08_kursanalys_2020.pdf - 2026-07-02
Cancer of unknown primary site (CUP) may be called an orphan disease, as it is diagnosed when metastases are detected while the primary tumor typically remains undetected, and because little research has been done on its primary causes. So far, few epidemiological studies, if any, have addressed possible risk factors for CUP. We analyzed data from the European Prospective Investigation into Cancer
Background: A novel generation of PET scanners based on silicon (Si)-photomultiplier (PM) technology has recently been introduced. Concurrently, there has been development of new reconstruction methods aimed at increasing the detectability of small lesions without increasing image noise. The combination of new detector technologies and new reconstruction algorithms has been found to increase image
Preterm birth carries a risk for adverse neurodevelopment. Cognitive dysfunctions, such as language disorders may manifest as atypical sound discrimination already in early infancy. As infant-directed singing has been shown to enhance language acquisition in infants, we examined whether parental singing during skin-to-skin care (kangaroo care) improves speech sound discrimination in preterm infant
Context. After more than 50 years, astronomical research still struggles to reconstruct the history of lithium enrichment in the Galaxy and to establish the relative importance of the various 7Li sources in enriching the interstellar medium (ISM) with this fragile element. Aims. To better trace the evolution of lithium in the Milky Way discs, we exploit the unique characteristics of a sample of op
BACKGROUND: Given the high heterogeneity among breast tumors, associations between common germline genetic variants and survival that may exist within specific subgroups could go undetected in an unstratified set of breast cancer patients. METHODS: We performed genome-wide association analyses within 15 subgroups of breast cancer patients based on prognostic factors, including hormone receptors, t
Background Fidanacogene elaparvovec, an adeno-associated virus (AAV) gene-therapy vector for hemophilia B containing a high-activity human factor IX variant (FIX-R338L/FIX-Padua), was associated with sustained factor IX activity in a phase 1-2a study. Methods We conducted a phase 3 open-label study of fidanacogene elaparvovec at a dose of 5×1011 vector genome copies per kilogram of body weight. Me
Publicerad 11 mars. Universitetsgemensamma nyheter Visa fler nyheter Aktuellt från universitetsledningen Erik Renström, rektorFrån rektorsbloggen: "När regeringen nyligen lade fram sin proposition om migrationsrättsliga regler för forskare och doktorander kan jag konstatera att den går i en riktning som ytterligare förenklar den för oss så viktiga mobiliteten för internationella forskare och dokto
https://www.medarbetarwebben.lu.se/kategori/lu-nytt-4-2026 - 2026-07-02
OBJECTIVES: To assess perineal anatomy using ultrasound before and immediately after delivery. METHODS: Structures in the perineum were studied by real-time two-dimensional transvaginal and endoanal ultrasound imaging using a combined linear and semicircular (up to 200 degrees sector) probe. We examined 45 nulliparous pregnant women and 44 primiparae immediately after delivery (40 with anal sphinc
Background Carrying the cyclin-dependent kinase inhibitor 2A (CDKN2A) germline mutations is associated with a high risk for melanoma. Penetrance of CDKN2A mutations is modified by pigmentation characteristics, nevus phenotypes, and some variants of the melanocortin-1 receptor gene (MC1R), which is known to have a role in the pigmentation process. However, investigation of the associations of both
