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Background Aortic valve calcification (AVC) is a disease process driven by inflammation and lipid infiltration, serving as a precursor to aortic stenosis. While male sex has been implicated as a risk factor for AVC, sex-specific differences, particularly among younger individuals in the general population, are not well characterised. Methods The Swedish CArdioPulmonary BioImage Study was used, com
BACKGROUND: A growing body of evidence links microRNAs (miRNAs) to major depressive disorder (MDD). However, the causal nature of these associations remains unclear.OBJECTIVES: This study aimed to investigate the potential causal association between miRNAs and MDD by combining Mendelian Randomization (MR) analyses and experimental validation.METHODS: Single-nucleotide polymorphisms (SNPs) signific
Psychological distress, including depression, anxiety, and stress, requires time-efficient assessment tools suited for digital and momentary settings. The Screening Tool for Psychological Distress (STOP-D) is a five-item scale developed for brief mental health screening, but it has not yet been validated in Swedish. This study aimed to evaluate the psychometric properties and diagnostic accuracy o
Accurate grading of Oil Palm Fresh Fruit Bunches (FFB) is pivotal for maximizing agricultural yield, yet manual assessment in unstructured environments remains labor-intensive and subjective. While Convolutional Neural Networks (CNNs) offer an automated solution, the conventional strategy of scaling network depth often yields diminishing returns or overfitting on moderately sized datasets. To over
This paper presents a lifetime assessment of a marine leisure vessel propulsion and charging architecture comprising Dual Active Bridge (DAB) converters and a threelevel Neutral Point Clamped (NPC) inverter with Boat-To-Grid (B2G) capability. Analytical lifetime models, combined with thermal-electrical simulations and realistic operating profiles, are used to estimate the durability of semiconduct
The rapid expansion of the global microgrid (MG) market requires a sustainable and resilient energy storage solution to manage the intermittent nature of renewable energy sources. While conventional battery storage systems are common, they present significant limitations in cost, lifespan, and environmental impact. This paper introduces green hydrogen energy storage (GHES) as a paradigm-shifting a
Time-domain induced polarization (TDIP) data carry spectral information that can be used for petrophysical interpretation. At the same time, TDIP data can be collected in the field more efficiently than frequency-domain induced polarization (FDIP) data, thanks to the use of square-wave signals. However, TDIP field data are prone to noise, particularly strong near industrial installations and urban
To generate the required antiproton beam intensity for the FAIR PANDA experiment, a dedicated proton LINAC (pLINAC) for the FAIR accelerator chain is being constructed. Klystron modulators are power converters within the high-power RF system of the pLINAC. Here, seven modulator systems with a nominal pulse power amplitude of 115 kV / 54 A, an effective pulse width of 360 µs and a pulse repetition
Introduction: Using time-limited trials of low-dose, sustained-release morphine to reduce chronic breathlessness to evaluate net effects may generate opioid withdrawal symptoms if medication is ceased. This sub-study of a larger randomized, placebo-controlled, double-blind trial aimed to evaluate if this occurred. Methods: People with modified Medical Research Council breathlessness scores of 3 or
Disclosed is a method (310) for providing operational feedback during power transfer in a wireless power transfer system. The wireless power transfer system comprises a power transmit device arranged to transfer power over an inductive wireless power transfer interface operating at a transmit frequency to a power receive device. The wireless power transfer system is adapted to transfer information
A search for R-parity-conserving supersymmetry in events with large missing transverse momentum, jets and at least one hadronically decaying τ-lepton is presented. Both gluino and squark pair production are considered, with the cascade decay of each gluino or squark producing either a τ-slepton or a τ-sneutrino. Three channels are examined, requiring either exactly one hadronically decaying τ-lept
Extreme heat is a growing public health threat in tropical Africa, especially in Ghana where outdoor maximum daily temperatures (Tx) regularly exceed 35 °C. Vulnerability to heat is socially and economically differentiated, with pregnant women, young children, elderly people, and people with chronic health conditions most at risk. High proportions of these groups are found in hospitals, yet little
This paper explores the changing nature of social institutions and organizations for resource management on Ontong Java and their central role in maintaining livelihoods. Using detailed field data for three time periods, 1970-72, 1986 and 2006-07, and drawing on earlier secondary data, a longitudinal analysis of changes in governance and livelihoods is undertaken. Increased exploitation of marine
Water balance models provide insights into ongoing changes in the water cycle. Among them, monthly water balance models (MWBMs) are especially suitable for large-sample and global assessments, which are important for adaptation to global environmental change. This study evaluates monthly water balances from 14 models across more than 2,000 global catchments, comparing the modelś capacities to repr
OBJECTIVES: To identify the lowest sensitivity and specificity that physicians and the general population consider acceptable for medical artificial intelligence (AI), relative to current human performance.METHODS: In a nationwide, cross-sectional survey in Sweden, 2025, random samples of 500 physicians and 500 adults from the general population were mailed a questionnaire presenting three vignett
The resilience performance of networked microgrids (NMGs) in disaster-prone areas, using a real-world testbed located in Lombok, Indonesia is explored in this paper. Given the increasing environmental pressures and energy security concerns in Indonesia, it is vital to improve the robustness and sustainability of decentralized energy infrastructures. We propose an optimization-based energy manageme
This study clarifies when Bayesian analysis provides a practical advantage, particularly in large-area searches, hazardous or inaccessible environments, and low signal-to-noise ratio (SNR) scenarios where direct source approach is not feasible. We present a PyMC-based Bayesian framework for localizing a single unshielded gamma-emitting source and estimating its activity, with the ability to switch
ObjectivesAutoantibodies against tissue transglutaminase (tTG) are serological markers of celiac disease. The aim was to study the applicability of human leukocyte antigen (HLA)-genotyping and tTG autoantibodies in the screening of celiac disease in a longitudinal birth cohort followed to age 15 years.MethodsIncluded were 13,860 HLA-DQ-genotyped children at birth and previously invited to a screen
