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Repetitive iodinated contrast media exposure may be harmful for the kidneys. The aim of the present study was to evaluate if patients with diabetes mellitus (DM) undergoing CT angiography (CTA) and local continuous thrombolysis for acute lower limb ischemia (ALI) had an increased risk of developing contrast-associated acute kidney injury (CA-AKI) compared to patients without DM. Methods: This is a
T-cell development provides an excellent model system for studying lineage commitment from a multipotent progenitor. The intrathymic development process has been thoroughly studied. The molecular circuitry controlling it has been dissected and the necessary steps like programmed shut off of progenitor genes and T-cell genes upregulation have been revealed. However, the exact timing between decisio
Klimatförändringarna förväntas påverka skogar i de tempererade och boreala zonerna och leda till omfattande förändringar i ekosystemens struktur och funktion. Därför behövs analyser av sannolika utfall av olika scenarier av ökad klimatpåverkan på lång sikt, för att förbättra kunskapsunderlaget och stödja beslutsfattande inom skogssektorn. För skogsägare innebär klimatförändringarna ett behov att öClimate change is expected to affect temperate and boreal forests, potentially causing profound changes to the functioning and the structure of ecosystems. This calls for assessments of the plausible long-term outcomes of a range of climate change scenarios to increase the knowledge base for decision making in forestry. Forest owners need to consider whether current silvicultural management practi
BACKGROUND: There is a growing body of evidence indicating the significant role of the immune system and immune cells in the progression of Alzheimer's disease (AD). However, the exact role of genes from various immune cell types in AD remains unclear. We aimed to utilize summary data-based Mendelian randomization (SMR) to explore the potential causal relationships between genes in specific immune
Background: The globally transmitted avian malaria parasite Plasmodium relictum (lineage SGS1) has been found to infect hundreds of different bird species with differences in infection outcomes ranging from more or less latent to potentially mortal. However, to date basic knowledge about the links between genetic differentiation and variation in infection outcome within this single malaria parasit
Th e performance of a mean field th eory (MFT) neu ralnetwork technique for finding approximate solutions to optimi zationproblems is invest igat ed for the case of th e minimum cut graph bisection problem, which is NP- complete. We address the issues of solut ionquality, programming complexity, convergence tim es and scala bility.Both standard random gr aphs an d mor e st ruct ured geomet ric gra
Based on t he Boltzmann Machine concept, we derive alear ning algorithm in which time-consuming stochastic measurementsof correlations a re replaced by solutions to dete rminist ic mean fieldtheory equ ations. T he method is applied to t he XOR (exclusive-or ),encoder, and line sym metry problems with substantial success. Weobserve speedup facto rs ranging from 10 to 30 for these ap plicat ionsand
We propose a simple architecture for implementing supervised neural network models optically with photorefractive technology. The architecture is very versatile: a wide range of supervised learning algorithms can be implemented including mean-field-theory, backpropagation, and Kanerva-style networks. Our architecture is based on a single crystal with spatial multiplexing rather than the more commo
Background and Objectives Structural brain MRI and blood-based phosphorylated tau (p-tau) measures are among the least invasive and least expensive Alzheimer's disease (AD) biomarkers to date. The extent to which these biomarkersmay outperformone another in predicting future Alzheimer dementia diagnosis is poorly understood, however. This study investigated 2 specific AD biomarkers, i.e., a cortic
The Chicxulub asteroid that ended the Cretaceous Era ∼66.05 million years ago caused a prolonged time of global darkness – the impact winter – leading to mass extinctions. Elements from the asteroid, including the platinum group elements (PGEs) osmium, iridium and platinum are known from the globally distributed boundary clay but their carrier elements have so far been unknown. We identify, for th
Background: Young adults experience stressors in their transition to adulthood and are at increased risk of mental ill-health. This risk is compounded by young adults’ low levels of mental health literacy and limited competencies in implementing strategies promoting mental health and well-being in their daily lives. Previous research suggests that digital mental health apps may be particularly eff
Background and Goal of StudyWe aimed to develop, implement and evaluate a mobile system using off-the-shelf components, torecord and review simulations and debriefings in four separate rooms during standardized simulation courses at multiple centres in Sweden. Ourrequirements were: high quality sound and video; easy to install, use and demount; suitable for transport by courier; no requirement to
Background: Biomarkers serve as a quantitative measure of brain injury and may predict cognitive outcome after cardiac arrest. This study investigates the association and predictive accuracy of acute changes in Alzheimer disease-associated biomarkers to cognitive outcome in cardiac arrest survivors.Methods: Retrospective study of the Target Temperature Management after Out-of-Hospital cardiac arreBackground: Biomarkers serve as a quantitative measure of brain injury and may predict cognitive outcome after cardiac arrest. This study investigates the association and predictive accuracy of acute changes in Alzheimer disease-associated biomarkers to cognitive outcome in cardiac arrest survivors.Methods: Retrospective study of the Target Temperature Management after Out-of-Hospital cardiac arre
Study region: Lake Vänern, the largest lake in the European Union, located in Sweden. Study focus: The study aimed to develop a spatially complete and temporally continuous lake surface water temperature (LSWT) dataset by fusing satellite remote sensing data with reanalysis products. Five satellite-derived LSWT products, including the Moderate Resolution Imaging Spectroradiometer (MODIS), were eva
To further understand the inter-relationship of the familial transmission of major depression (MD) and alcohol use disorder (AUD), we examine, via a multivariable Cox proportional hazards model, risks for AUD and MD in 1,244,516 individuals born in Sweden from 1970 to 1990 to intact mother-father pairs as a function of parental diagnoses of MD and/or AUD. Across the nine possible mating types, we
Robots operating in real-world settings must manage task variability, environmental uncertainty, and failures during execution. This thesis presents a unified framework for building self-reliant robotic systems by integrating symbolic planning, reinforcement learning, behavior trees (BTs), and vision-language models (VLMs).At the core of the approach is an interpretable policy representation based
This study presents a conceptual framework for assessing the sustainability of the forest-based economy and resulting synergies and trade-offs between forest harvest, carbon sequestration, and biodiversity conservation. The framework adopts a comprehensive systems approach to map economic activities and associated flows of resources and embodied environmental impacts along the value chain. It buil
Label-free chemical imaging of living and functioning systems is the holy grail of biochemical research. However, existing techniques often require extensive sample preparation to remove interfering molecules such as water, rendering many molecular imaging techniques unsuitable for in situ structural studies. Here, we examined freshly extracted tissue biopsies and living small vertebrates at submi
