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Protein E (PE) is a ubiquitous multifunctional surface protein of Haemophilus spp. and other bacterial pathogens of the Pasteurellaceae family. H. influenzae utilizes PE for attachment to respiratory epithelial cells. In addition, PE interacts directly with plasminogen and the extracellular matrix (ECM) components vitronectin and laminin. Vitronectin is a complement regulator that inhibits the for
Genome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer (EOC) susceptibility alleles. The pattern of association at these loci is consistent in BRCA1 and BRCA2 mutation carriers who are at high risk of EOC. After imputation to 1000 Genomes Project data, we assessed associations of 11 million genetic variants with EOC risk from 15,437 cases unselected for family history
Introduction Bladder exstrophy is a rare congenital malformation of the bladder and is believed to be a complex disorder with genetic and environmental background. We describe a young adult female with an isolated bladder exstrophy and with an X chromosome aberration. Patients and Methods Karyotyping identified an X chromosome rearrangement that was further characterized with array comparative gen
A search for the b (b) over bar decay of the Standard Model Higgs boson is performed with the ATLAS experiment using the full dataset recorded at the LHC in Run 1. The integrated luminosities used are 4.7 and 20.3 fb(-1) from pp collisions at root s = 7 and 8 TeV, respectively. The processes considered are associated (WIZ)H production, where W -> e nu/mu nu, Z -> ee/mu mu, and Z -> nu nu. The obse
In this study, the photoelectrochemical behavior of electrodeposited FeNiOOH/Fe2O3/graphene nanohybrid electrodes is investigated, which has precisely controlled structure and composition. The photoelectrode assembly is designed in a bioinspired manner where each component has its own function: Fe2O3 is responsible for the absorption of light, the graphene framework for proper charge carrier trans
Imprinted genes, giving rise to parent-of-origin effects (POEs), have been hypothesised to affect type 1 diabetes (T1D) and rheumatoid arthritis (RA). However, maternal effects may also play a role. By using a mixed model that is able to simultaneously consider all kinds of POEs, the importance of POEs for the development of T1D and RA was investigated in a variance components analysis. The analys
The production cross-sections for W± and Z bosons are measured using ATLAS data corresponding to an integrated luminosity of 4.0 pb- 1 collected at a centre-of-mass energy s=2.76 TeV. The decay channels W→ ℓν and Z→ ℓℓ are used, where ℓ can be an electron or a muon. The cross-sections are presented for a fiducial region defined by the detector acceptance and are also extrapolated to the full phase
Peatlands store large amounts of carbon in terrestrial ecosystems and they are vulnerable to recent warming. The ongoing warming may change their carbon sink capacity and could reduce their potential to sequester carbon. In this study, we simulated peatland carbon dynamics in distinct future climate conditions using the peatland-vegetation model (LPJ-GUESS). The study examined whether less pronoun
The thawing and subsequent decomposition of large stocks of soil organic carbon (SOC) currently stored in the northern circumpolar permafrost region are projected to result in a ‘positive’ feedback on global warming. The magnitude of this feedback can only be assessed with improved knowledge about the total size and geographic distribution of the permafrost SOC pool. This study investigates SOC st
The COP 15 of the UN Convention on Biological Diversity emphasised the need to monitor, evaluate, and disclose the risks and dependencies of financial institutions on biodiversity. In the light of this context, our paper focuses specifically on banks and is framed by the following overarching question: to what extent have banks identified, integrated, measured, and disclosed their dependency and e
Atmospheric measurements show that emissions of hydrofluorocarbons (HFCs) and hydrochlorofluorocarbons are now the primary drivers of the positive growth in synthetic greenhouse gas (SGHG) radiative forcing. We infer recent SGHG emissions and examine the impact of future emissions scenarios, with a particular focus on proposals to reduce HFC use under the Montreal Protocol. If these proposals are
(1) Background: To identify reasons for the persistence of surgical ligation of the patent ductus arteriosus (PDA) in premature infants after the 2019 Food and Drug Administration (FDA) approval of transcatheter device closure; (2) Methods: We performed a 10-year (2014–2023) single-institution retrospective study of premature infants (<37 weeks) and compared clinical characteristics and neonatal m
