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The partial unfolding of human lysozyme underlies its conversion from the soluble state into amyloid fibrils observed in a fatal hereditary form of systemic amyloidosis. To understand the molecular origins of the disease, it is critical to characterize the structural and physicochemical properties of the amyloidogenic states of the protein. Here we provide a high-resolution view of the unfolding p
The classical pathway complement regulator C4b-binding protein (C4BP) is composed of two polypeptides (alpha- and beta-chains), which form three plasma oligomers with different subunit compositions (alpha(7)beta(1), alpha(7)beta(0), and alpha(6)beta(1)). We show in this article that the C4BP alpha(7)beta(0) isoform (hereafter called C4BP[beta(-)] [C4BP lacking the beta-chain]), overexpressed under
The purpose of this work was to evaluate three motion-monitoring systems: Sentinel (TM), Catalyst (TM) (both C-RAD) and Real-time Position Management (RPM (TM)) system (Varian Medical Systems Inc) for respiratory gating in radiotherapy. To measure the systems. latency, an in-house built circuit with a microcontroller operating a piston was used. The trigger pulse was sent from the gating systems t
The three Mn I lines at 17325, 17339, and 17349 angstrom are among the 25 strongest lines (log(gf) > 0.5) in the H band. They are all heavily broadened due to hyperfine structure, and the profiles of these lines have so far not been understood. Earlier studies of these lines even suggested that they were blended. In this work, the profiles of these three infrared (IR) lines have been studied theor
Malaria is a major global cause of deaths and a vaccine is urgently needed.
Abstract – Background: Cytological examination of a fine-needle aspirate (FNA) is a minimally invasive modality that is increasingly used in the diagnosis of lymphoma. Flow cytometry and other ancillary tests make an important contribution to the diagnostic value of FNAs of lymphoid lesions. This review follows the recent publication of the first edition of the WHO Reporting System for Lymph Node,
BACKGROUND: In patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) and who are treated with direct oral anticoagulants (DOACs), dual antithrombotic treatment without aspirin is recommended. Evidence comparing P2Y 12 inhibitor strategies in this setting is limited. AIMS: This study aimed to compare outcomes with ticagrelor versus clopidogrel as part of
The dissociation of NO is a critical step in its catalytic reduction to N2, which is key to automotive exhaust treatment. Here, we examine the role of Rh atomic steps in the NO dissociation reaction under 0.05 mbar NO. We use a Rh crystal sample curved around the (111) direction and ambient-pressure X-ray photoelectron spectroscopy to probe different Rh surfaces subject to the very same reaction c
Immunoglobulin G subclass deficiencies (IgGSD) are associated with recurrent respiratory tract infections. Tools to identify patients with IgGSD who benefit from immunoglobulin G replacement therapy (IgGRT) are lacking. This crossover study evaluated the number of antibiotic-demanding infections on and after up to 18 mo off IgGRT in 28 patients with IgGSD. Pneumococcal antibodies against 21 seroty
Denna uppsats behandlar fattigdomsbekämpning utifrån svensk biståndspolitik. Bi-ståndsgivning har länge varit en självklar del i både internationell och svensk politik, ändå har inga större framgångar skett med att utrota fattigdom. Syftet med uppsatsen är att utvärdera Sveriges politik om bistånd genom det senast utgivna dokumentet om bi-ståndspolitik – Biståndspolitisk plattform – utgiven av regThis essay concern poverty alleviation through Swedish aid policy. Giving aid has been an evident part of both international and Swedish policy for a long time, yet there has been no great success with eradicating poverty. The purpose is to evaluate Sweden’s aid policy through its most recently published document on aid policy, which the govern-ment published in March 2014. The document will be an
Villa San Michele and Villa Lysis, formerly homes to Swedish doctor Axel Munthe and baron Jacques d’Adelswärd Fersen, now stand as two museums in Capri, Italy. The essay investigates their current state through a phenomenological tour, complying with Tonino Grifferos’s theory of a neo-phenomenological and philosophic “pathic aesthetic”. This theory argues for the presence of the beholder in their
Staters interventionism har legat bakom många grova människorättskränkningar. Eftersom FN-systemets vetorätt skyddar vissa stater från straffrättsligt ansvar finns det få reella utsikter för en minskning av dessa människorättsbrott. Inom det institutionella systemet är den Internationella Brottmålsdomstolen ICC och det möjliga aktiverandet av dess jurisdiktion över aggressionsbrottet – som nu befi
The cultural significance of dairy milk in Sweden is deeply ingrained, with dairy products being a staple at the breakfast table. However, the past decade has witnessed a formidable challenge to the traditional Swedish dairy industry, with the rise of plant-based milk alternatives. The emergence of new preferences has spurred the ascent of brands like Oatly. The Swedish oat drink producer Oatly, w
Förintelsen är ett skrämmande exempel på vad som kan ske när man inte erkänner människors lika värde. Romerna, jämte judarna, var grupper som utsattes för nazisternas systematiska förföljelse på rasmässiga grunder. Trots en traumatisk historia fortsätter Förintelsen av romer att hamna i utkanten av minnespolitiken. Syftet med denna uppsats är att undersöka och analysera närvaron, bristen eller frå
Background and aims: Animal studies have suggested that high salt intake might increase the risk of metabolic dysfunction-associated steatotic liver disease (MASLD), but results from populations are mixed, in part due to inadequate salt intake measurement. Salty taste preference is the primary factor leading to salt choice and can reflect habitual salt intake. However, no study has investigated
Virtual reality (VR) offers promising opportunities for procedural learning, particularly in preserving intangible cultural heritage. Advances in generative artificial intelligence (Gen-AI) further enrich these experiences by enabling adaptive learning pathways. However, evaluating such adaptive systems using traditional temporal metrics remains challenging due to the inherent variability in Gen-A
The study explores the challenges of increased use of wood-frames in multi-story buildings in Sweden and its implications for fire safety. It investigates incident statistics and fire damages in wooden buildings, aiming to enhance the impact and safety of operations in these buildings. The study identifies a lack of incident statistics for wooden buildings, emphasizing challenges in structural fir
Krita-paleogen-gränsen har länge varit central i diskussioner mellan forskare runt om i världen, då den markerar/sammanfaller med utdöendet av 75% av jordens arter till följd av ett enormt asteriodnedslag på Chicxulúbhalvön i Mexiko. Gränsintervallet är vida utbrett i sedimentära lagerföljder som bildades under denna tid, och kan identifieras genom sina unika kemiska egenskaper och karakteristiskaThe Cretaceous-Paleogene boundary has long been a center of discussion amongst scientists as it marks the extinction of 75% of all species on Earth. This mass extinction event was probably caused by an enormous asteroid impact event in what is now Mexico. The boundary interval is easily identified in the sedimentary geological record because of its unique chemical properties as well as its charact
I ett entreprenadavtal regleras det normalt huruvida det är beställaren eller entreprenören som ska bära ansvaret för att en entreprenad försenats. En situation som mer sällan regleras är vem av parterna som ska bära risken om det föreligger konkurrerande förseningsorsaker. Avsikten med förevarande framställning är därför att analysera hur en domstol skulle bedöma en entreprenörs krav på tidsförläNormally, the contract governing a construction project regulates whether the contractor or the employer shall bear the risk of a delay. Nevertheless, the parties rarely include in their contract provisions how liability for concurrent delays should be dealt with. Therefore, the purpose of this thesis is to examine how the Swedish courts would treat claims from a contractor for an extension of tim
