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Objective: Primary adrenal insufficiency [Addison's disease (AD)] is rare, and systematic studies are few, mostly conducted on small patient samples. We aimed to determine the clinical, immunological, and genetic features of a national registry-based cohort. Design: Patients with AD identified through a nationwide search of diagnosis registries were invited to participate in a survey of clinical f
BACKGROUND: It is difficult to estimate the diagnostic accuracy of biopsy for prostate cancer because men with negative biopsy do not undergo radical prostatectomy and thus have no confirmation of biopsy findings. METHODS: We performed 18-core needle biopsies on autopsy prostates from 164 men who had no history of prostate cancer. Six-core biopsies were taken from each of the mid peripheral zone (
The complement system plays an important role in eliminating invading pathogens. Activation of complement results in C3b deposition (opsonization), phagocytosis, anaphylatoxin (C3a, C5a) release, and consequently cell lysis. Moraxella catarrhalis is a human respiratory pathogen commonly found in children with otitis media and in adults with chronic obstructive pulmonary disease. The species has ev
This work deals with the problem of direction of arrival estimation of interferometric synthetic aperture radar (InSAR) signals in presence of layover. The focus here is on realistic acquisition systems with a low number of phase centres and nonuniform array geometry. An interpolated array approach is proposed, in order to apply spectral estimation techniques designed for uniform linear arrays. In
Reactive oxygen species (ROS) are considered to be an indicator of particle-induced toxicity. We used a novel instrument, called Particle Into Nitroxide Quencher (PINQ), for real-time quantification of ROS for assessment of indoor particle sources. Of the sources tested, cigarette smoke was found to contain the highest ROS concentration, several times higher than incense smoke and secondary organi
In the ongoing library debate part of the focus has been on youth in libraries and how many libraries find them to be a challenging group to work with due to some occurring disturbances. In some cases the youth sections start to lean towards being youth recreation centers. Youth need somewhere to be that isn’t home or school and since there aren’t many open, free of cost public spaces, and many ci
GABA (gamma-aminobutyric acid), the main inhibitory neurotransmitter in the central nervous system is also present in the pancreatic islet beta cells where it may function as a paracrine molecule and perhaps as an immunomodulator of lymphocytes infiltrating the pancreatic islet. We examined CD4(+) and CD8(+) T cells from diabetes prone (DRlyp/lyp) or resistant (DR+/+) congenic biobreeding (BB) rat
Environmental factors, including viral infections, may explain an increasing and fluctuating incidence of childhood type 1 diabetes (T1D). Ljungan virus (LV) isolated from bank voles have been implicated, but it is unclear whether LV contributes to islet autoimmunity, progression to clinical onset, or both, of T1D. The aim was to test whether LV antibodies (LVAb) were related to HLA-DQ and islet a
Today, innovation is a key word for many universities, as it constitutes an important part of most universities’ public and scientific outreach task. Many universities are striving to increase the number of innovations generated at the university. A common method is to provide various support for research projects e.g.; providing researchers with information about international patent rights (IPR)
Popular Abstract in Swedish Vårt immunsystem består av ett nätverk av olika sorters celler och molekyler, vars uppgift är att försvara oss mot patogener (sjukdomsalstrande organismer) som till exempel virus och bakterier, medan det samtidigt måste tolerera proteiner och ämnen som finns naturligt i vår kropp. Immunsystemet kan delas upp i två delar; det medfödda (eller ospecifika) och det adaptiva Mucosal tissues such as the intestine present an enormous surface area to the outside environment and are continually exposed to foreign antigens in food and microflora. Thus, the intestinal mucosa must must remain tolerant to these innocuous antigens while at same time be able to mount effective immune responses to pathogens. Intestinal dendritic cells (DCs) and macrophages, found throughout the
This study examines the motif of the Fallen World in Coleridge’s major poems The Ancient Mariner, Christabel and Kubla Khan . The use of Milton’s Paradise Lost as an intertextual foil throughout allows themes and metaphors inherent in the Fallen World motif to emerge in Coleridge’s poetry. A Fall presupposes a standard from which one has been separated downwards. Primarily, it is understood as man
Arbetet behandlar införandet av så kallade säkerhetszoner i Sverige och analyserar säkerhetszonerna ur ett rättssäkerhetsperspektiv. Säkerhetszoner möjliggör för polisen att genomföra kroppsvisitationer och fordonskontroller utan krav på konkret brottsmisstanke inom ett geografiskt avgränsat område. För-slaget om säkerhetszoner återfinns i det så kallade Tidöavtalet och har sedermera lett till lagThis thesis explores the legal implications of introducing so-called security zones in Sweden and analyzes them from a rule of law perspective. These zones allow police to conduct body searches and vehicle inspections without requiring specific criminal suspicion within designated geographic areas. Introduced as part of the Tidö Agreement (Tidöavtalet) and now legislated, security zones aim to com
1 LUNDS UNIVERSITY Department of Archaeology and Ancient History _______________________________________________________________________________________________________________________________________________________ Reading list – ARKN20, Lives of Roman buildings: construction, reconstruction, destruction, 7.5 credits Established by the Board of the Department: 2020-02-18 The literature is availa
https://www.ark.lu.se/media/utbildning/dokument/kurser/ARKN20/20201/Reading_list_ARKN20_Lives_of_Roman_buildings.pdf - 2026-07-17
The perforated whole-cell configuration of the patch-clamp technique was applied to functionally identified beta-cells in intact mouse pancreatic islets to study the extent of cell coupling between adjacent beta-cells. Using a combination of current- and voltage-clamp recordings, the total gap junctional conductance between beta-cells in an islet was estimated to be 1.22 nS. The analysis of the cu
Autoantibodies to glutamate decarboxylase 65 (GAD65Ab) are commonly believed to be a major characteristic for type 1 diabetes (T1D). We investigated the presence of GAD65Ab in healthy individuals (n = 238) and first-degree relatives (FDRs) of T1D patients (n = 27) who tested negative for GAD65Ab in conventional RIAs. Sera were applied to affinity columns coated with GAD65-specific mAbs to absorb a
Around 100,000 refugees are resettled to dozens of countries from conflict zones every year. While there is growing evidence that the initial placement of refugee families profoundly affects their lifetime outcomes, there have been few attempts to optimize resettlement destinations within host countries. We describe how machine learning and integer optimization can be used to empower resettlement
The SIRPα-CD47 axis plays an important role in T cell recruitment to sites of immune reaction and inflammation but its role in T cell antigen priming is incompletely understood. Employing OTII TCR transgenic mice bred to Cd47-/- (Cd47KO) or SKI mice, a knock-in transgenic animal expressing non-signaling cytoplasmic-truncated SIRPα, we investigated how the SIRPα-CD47 axis contributes to antigen pri
