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Popular Abstract in Swedish Populärvetenskaplig sammanfattning Öroninflammtionen är en av våra vanligaste åkommor, och den drabbar framför allt små barn. Av alla bakteriella infektioner är det den som oftast för oss till läkare. Vanligen resulterar läkarbesöket i en kur med bakteriedödande läkemedel som penicillin. P.g.a den idag höga konsumtionen av penicillin och liknande medel, är risken påtagAcute otitis media (AOM) is the most common illness diagnosed during early childhood. One of the major etiologic agents is Haemophilus influenzae. Apart from AOM, this organism can cause a broad range of infectious diseases such as meningitis, epiglottitis, arthritis, and pneumonia. Despite the importance of H.influenzae, the mechanisms by which this heterogenous group of bacteria mediates the inf

Clock nets are the major source of power consumption in large, high-performance ASICs and a design bottleneck when it comes to tolerable clock skew. A way to obviate the global clock net is to partition the design into large synchronous blocks each having its own clock. Data with other blocks is exchanged asynchronously using handshake signals. Adopting such a strategy requires a methodology that

We consider the problem of stochastic control under power constraints. Problems such as linear quadratic optimal control with information constraints are instances of the problem considered. The calculations of the optimal control law can be done off-line as in the classical linear quadratic Gaussian control theory using dynamic programming, which turns out to be a special case of the new theory d

Non-typeable Haemophilus influenzae (NTHi) is a human pathogen causing diseases in the upper and lower respiratory tract. Otitis media-prone children and adults with cystic fibrosis or chronic obstructive pulmonary disease, are repeatedly infected by NTHi Research in recent years brought to light the entry and survival of NTHi in epithelial cells and macrophages. Their internalization could be a

Popular Abstract in Swedish Kan immunförsvaret orsaka ledsjukdomar? Ett väl fungerande immunsystem är en förutsättning för att kroppen ska kunna bekämpa diverse sjukdomar orsakade av t. ex. virus och bakterier. En grundläggande egenskap hos immunsystemet är dess förmåga att kunna skilja på vad som är kroppens egna celler och molekyler och vad som är främmande. Man tror att vissa sjukdomar, så kalCollagen-induced arthritis (CIA) is a mouse model for rheumatoid arthritis, in which autoimmunity is induced by immunization with type II collagen (CII), a cartilage-specific protein. In the present work, alpha/beta T cells were shown to be required for CIA and for the production of anti-CII IgG antibodies, whereas gamma/delta T cells were neither necessary nor sufficient for development of CIA. A

In recent years, a number of planetary systems have been proposed to orbit-evolved binary star systems. The presence of planets is invoked to explain observed variations in the timing of mutual eclipses between the primary and secondary components of the binary star system. The planets recently proposed orbiting the cataclysmic variable system QS Virginis are the latest in this ongoing series of `

Both Haemophilus influenzae type b (Hib) and nontypeable H. influenzae (NTHi) are important human pathogens causing invasive and mucosal infections. Currently there are number of vaccines available against Hib infections. Hib vaccines consist of the capsular polysaccharide antigen, polyribosyl ribitol phosphate (PRP) of Hib, coupled to different protein carriers. These vaccines are not effective a

A number of trends like globalisation, outsourcing, single sourcing, and leanness have together created a more vulnerable supply chain. This increased vulnerability has made supply chain risk issues a hot topic in academia as well as in industry. There has, however, been a lack of suitable models. The objective of this paper is to develop one such model – a conceptual model with the help of which

Background: The acceptable noise level (ANL) test is a method for quantifying the amount of background noise that subjects accept when listening to speech. Large variations in ANL have been seen between normal-hearing subjects and between studies of normal-hearing subjects, but few explanatory variables have been identified. Purpose: To explore a possible relationship between a Swedish version of

Recombinant adeno-associated viral vectors display efficient tropism for transduction of the dopamine neurons of the substantia nigra. Taking advantage of this unique property of recombinant adeno-associated viral vectors, we expressed wildtype and A53T mutated human alpha-synuclein in the nigrostriatal dopamine neurons of adult rats for up to 6 months. Cellular and axonal pathology, including alp

Objective. Human papilloma virus (HPV) testing and repeat cytology are both proposed as methods to triage women with minor cytological cervical lesions. By triage, those women can be identified who need referral for diagnostic exploration with colposcopy and/or biopsy. Methods. We conducted meta-analyses of reported studies on the accuracy to detect high-grade cervical intra-epithelial neoplasia o

Neisseria gonorrhoeae is the causative agent of gonorrhea, a disease that is restricted to humans. Complement forms a key arm of the innate immune system that combats gonococcal infections. N. gonorrhoeae uses its outer membrane porin (Por) molecules to bind the classical pathway of complement down-regulatory protein C4b-binding protein (C4bp) to evade killing by human complement. Strains of N. go

Dendritic cells present microbial antigens to T cells after uptake of apoptotic vesicles from infected cells. We previously reported that immunizations with apoptotic HIV-1/murine leukemia virus (MuLV) infected cells lead to induction of both cellular and humoral immune responses as well as resistance to mucosal challenge with live HIV-1/MuLV infected cells. Here we extended those studies and inve

Background: Many strategies are currently being pursued in order to generate mature dendritic cells (DC) to be used for immunotherapy. A potent anti-tumour influence by extracorporeal photopheresis has been documented for cutaneous T-cell lymphoma, and a major mechanism of action has been suggested to be generation of DC presenting tumour antigens. Purpose: To determine the potential of a simple c

OBJECTIVE: To compare the reliability of quantitative measurement of minimum hip joint space with a qualitative global assessment of radiological features for estimating the prevalence of primary osteoarthritis (OA) of the hip in colon radiographs.METHODS: All colon radiographs from patients aged 35 or older, taken at three different radiographic departments in Iceland during the years 1990-96, we

Popular Abstract in Swedish Avhandlingen utgörs av en kritisk edition av Johannes Annorelius? latinska brev till brodern Julius (G3, Uppsala universitetsbibliotek). I början av 1700-talet lämnade Johannes Annorelius Uppsala och blev katolik och kapucinmunk i Flandern. Från klostret skrev han många, långa brev på franska och latin till sin lutherske bror i Sverige. I breven förklarar han varför hanThis book presents a critical edition of the Latin letters in ms. G3 (Uppsala University Library) from Johannes Annorelius to his brother. Johannes Annorelius left Sweden as a young student in the beginning of the 18th century and settled down in Flanders, where he converted to the Catholic faith and became a Capuchin friar. In the Capuchin friary Annorelius wrote several extensive letters in Fren

The coexistence of two lamellar liquid-crystalline phases in equilibrium for binary surfactant-water systems is a rare and still puzzling phenomenon. In the few binary systems where it has been demonstrated experimentally, the surfactant is invariably ionic and the miscibility gap is thought to stem from a subtle balance between attractive and repulsive interbilayer forces. In this paper, we repor

We proposed a 4×8 array antenna with aperture-coupled patch antenna elements. The antenna was designed for 60 GHz operation and fabrication on the low-temperature cofired ceramic(LTCC) substrate(εr=5.8). The feedline with the stub was designed to enhance the radiating element bandwidth and the transition characteristics between the waveguide (WG) and microstrip line(MSL). Through the optimization

We have investigated the interactions between cationic poly(amidoamine) (PAMAM) dendrimers of generation 4 (G4), a potential gene transfection vector, with net-anionic model biomembranes composed of different ratios of zwitterionic phosphocholine (PC) and anionic phospho-l-serine (PS) phospholipids. Two types of model membranes were used: solid-supported bilayers, prepared with lipids carrying pal