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Background: WNT5A (-/-) mammary tissue has been shown to exhibit increased ductal elongation, suggesting elevated mammary cell migration. Increased epithelial cell migration/invasion has often but not always been linked to the epithelial-mesenchymal transition (EMT). In the current study, we investigated the loss of WNT5A in HB2 human mammary epithelial cells and hypothesized that this loss increa
Background: T1D and AITD are autoimmune disorders commonly occurring in the same family and even in the same individual. The genetic contribution to these disorders is complex making uncovering of susceptibility genes very challenging. The general aim of this study was to identify loci and genes contributing to T1D/AITD susceptibility. Our strategy was to perform linkage and association studies in
Diffusion är den slumpmässiga rörelse hos partiklar som drivs av deras kinetiska energi. Den är oftast osynlig för blotta ögat, men den utgör en viktig funktion för vår överlevnad. Diffusionen står bland annat för transporten av näringsämnen över cellmembran, och det är diffusionen som gör att ämnen i kroppen blandas så att livsviktiga kemiska reaktioner kan ske.Man kan undersöka diffusionsprocessDiffusion MRI provides a non-invasive probe of tissue microstructure. We recently proposed a novel method for diffusion-weighted imaging, so-called q-space trajectory encoding, that facilitates tensor-valued diffusion encoding. This method grants access to b-tensors with multiple shapes and enables us to probe previously unexplored aspects of the tissue microstructure. Specifically, we can disenta
The aim of this study is to describe the environmental and climate changes that occurred in the mountains of Aubrac at the transition between the Lateglacial and the Holocene, from a comparative analysis of fossil Coleoptera and pollen, and a series of 23 14C dates. The changes affecting the ecological categories of Coleoptera lead to a division of the sequence into 5 beetle assemblage zones (BAZ)
The notion of species as reproductively isolated units related through a bifurcating tree implies that gene trees should generally agree with the species tree and that sister taxa should not share polymorphisms unless they diverged recently and should be equally closely related to outgroups. It is now possible to evaluate this model systematically. We sequenced multiple individuals from 27 describ
Oligodendrocyte (OL) death may contribute to white matter pathology, a common cause of network dysfunction and persistent cognitive problems in patients with traumatic brain injury (TBI). Oligodendrocyte progenitor cells (OPCs) persist throughout the adult CNS and may replace dead OLs. OL death and OPCs were analyzed by immunohistochemistry of human brain tissue samples, surgically removed due to
Reactive oxygen species (ROS) are thought to contribute to the secondary injury process after traumatic brain injury (TBI). ROS scavenging compounds have shown neuroprotective properties in various models of experimental brain injury, including TBI. Administration of nitrone radical scavengers has emerged as a promising pharmacological concept in focal experimental ischemia due to their low toxici
OBJECTIVE: To evaluate the effects of the neurological "wake-up test" (NWT), defined as interruption of continuous propofol sedation and evaluation of the patient's level of consciousness, on intracranial pressure (ICP) and cerebral perfusion pressure (CPP) in patients with severe subarachnoid hemorrhage (SAH) or traumatic brain injury (TBI).METHODS: A total of 127 NWT procedures in 21 severely br
Magnetomotive ultrasound imaging is an emerging technique where superparamagnetic iron oxide nanoparticles can be used as an ultrasound contrast agent. A time-varying external magnetic field acts to move tissue embedded particles, and ultrasound is used to detect the resulting tissue movement. In this experimental phantom study we observed a variation in the magnetomotive response in respect to ph
Axonal injury is an important contributor to the behavioral deficits observed following traumatic brain injury (TBI). Additionally, loss of myelin and/or oligodendrocytes can negatively influence signal transduction and axon integrity. Apoptotic oligodendrocytes, changes in the oligodendrocyte progenitor cell (OPC) population and loss of myelin were evaluated at 2, 7 and 21 days following TBI. We
Helianthemum nummularium s.l. is a young, morphologically diverse species distributed from western Europe to the Caucasus and the Southern Urals in the east. We analysed the rps16-trnK plastid intergenic spacer sequences from 85 localities covering most of the range of H. nummularium. Thirteen haplotypes were very unevenly distributed throughout the range of the species, and exhibited a strong phy
Identification of agricultural pest insects is an important aspect in insect research and agricultural monitoring. We have performed a methodological study of how spectroscopic techniques and wing-beat frequency analysis might provide relevant information. An optical system based on the combination of close-range remote sensing and reflectance spectroscopy was developed to study the optical charac
The aim of this study was to determine how self-presentation is formulated in victim supporters’ narratives of their interactions with crime victims, and identify the function of the presentation of the crime victim in this self-presentation. This was done through a narrative analysis of material from 12 focus groups in which representatives of Victim Support Sweden discussed their work. A master
Lund University has offered the Sida-financed International Training Programme on Child Rights, Classroom and School Management since 2003. The programme targets those in a position from which they can initiate processes of change in the education sector in their countries. During the programme all partici¬pating teams initiate a change project in their respective countries aiming at the reali¬zat
Lund University has offered the Sida-financed International Training Programme on Child Rights, Classroom and School Management since 2003. The programme targets those in a position from which they can initiate processes of change in the education sector in their countries. During the programme all participating teams initiate a change project in their respective countries aiming at the realizatio
Lund University has offered the Sida-financed International Training Programmeon Child Rights, Classroom and School Management since 2003. The programmetargets those in a position from which they can initiate processes ofchange in the education sector in their countries. During the programme all participating teams initiate a change project in their respective countries aiming atthe realization of
Lund University has offered the Sida-financed International Training Programmeon Child Rights, Classroom and School Management since 2003. The programmetargets those in a position from which they can initiate processes of change in theeducation sector in their countries. During the programme all participating teamsinitiate a change project in their respective countries aiming at the realization of
Lund University has offered the Sida-financed International Training Programmeon Child Rights, Classroom and School Management since 2003. The programmetargets those in a position from which they can initiate processes of change in theeducation sector in their countries. During the programme all participating teamsinitiate a change project in their respective countries aiming at the realization of
Lund University has offered the Sida-financed International Training Programme on Child Rights, Classroom and School Management since 2003. The programme targets those in a position from which they can initiate processes of change in the education sector in their countries. During the programme all participating teams initiate a change project in their respective countries aiming at the realizatio
