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BackgroundBiological heterogeneity of large B cell lymphomas (LBCLs) is poorly captured by current prognostic tools, hampering optimal treatment decisions.MethodsWe dissected the levels of 1,463 serum proteins in a uniformly treated trial cohort of 109 patients with high-risk primary LBCL (ClinicalTrials.gov: NCT01325194) and correlated the profiles with molecular data from tumor tissue and circul
Background: Hydrophilic polymer embolization (HPE) is a scarcely reported complication associated with endovascular procedures where the hydrophilic coating dislodges and disseminates to more distal vascular beds, leading to ischemic complications. The aim of this study is to assess the clinical outcomes associated with HPE in the literature and try to quantify it in a scoping manner. Methods: All
How does discomfort affect research interviewing? Recent contributions suggest that researchers do not always experience discomfort as problematic but also as productive. We explore our experiences of, and strategies for, uncomfortable interviews. Based on experiences of interviewing right-wing populist Twitter activists in the United States and Sweden, we make four claims. First, discomfort may a
BACKGROUND: Lung transplantation remains hampered by a scarcity of viable donor lungs, partially attributed to donor lung injuries.METHODS: Three porcine lung injury models were studied: infection-induced using lipopolysaccharide (n = 7), aspiration-induced using endotracheal gastric content (n = 7), and injury using lavage and harmful ventilation (ventilator-induced lung injury; n = 7). Molecular
Does socially desirable responding produce exaggerated correlations between self-ratings of personality and positive psychology constructs? We operationalized social desirability as the evaluative factor, i.e. the tendency to react to evaluative content in questionnaire items and related one standard measure and one evaluatively neutralized measure of the Big Five to measures of five key positive
Hen egg-white lysozyme (HEWL) is a widely used model protein in crystallographic studies and its enzymatic mechanism has been extensively investigated for decades. Despite this, the interaction between the reaction intermediate and the catalytic Asp52, as well as the orientation of Asn44 and Asn46 side chains, remain ambiguous. Here, we report the crystal structures of perdeuterated HEWL and D2O b
Serum Amyloid A (SAA) proteins are acute-phase reactants with critical roles in sterile and bacterial inflammation. Through in vitro and in vivo experiments, we demonstrate that SAA proteins amplify cytokine and chemokine responses during sterile inflammation and enhance bacterial clearance in infectious conditions. Mechanistically, SAA proteins augment NF-κB signaling, driving pro and anti-in
Nonlinear phenomena (NLP) are often associated with high arousal and function to grab attention and/or signal urgency in vocalizations such as distress calls. Although biomechanical models and in vivo/ex vivo experiments suggest that their occurrence reflects the destabilization of vocal fold vibration under intense subglottal pressure and muscle tension, comprehensive descriptions of the dynamics
The EU AI Act aims to regulate artificial intelligence (AI) in a way that balances innovation and protection from harms, but faces the challenge of keeping pace with the development of AI. This paper examines the tension between fixity and flexibility when regulating AI in the EU by drawing on literature on the pacing problem and anticipatory governance, contrasted by sociolegal theory on the impo
In July 2020, two Holocaust memorials disappeared from a Jewish cemetery in Stockholm where Holocaust survivors who died soon after coming to Sweden for medical treatment in 1945 are buried. Though it occurred in the midst of both the global #TakeItDown movement and the Swedish government’s plans to establish a Holocaust museum in Sweden, this removal garnered no media attention or public outcry.
For decades, extensive surfactant libraries have been developed to meet the requirements of downstream applications. However, achieving functional diversity has traditionally demanded a vast array of chemical motifs and synthetic pathways. Herein, a new approach for surfactant design based on structural isomerism is utilised to access a wide spectrum of functionalities. A library of C18-aliphatic
The orientation of juvenile marsh warblers during autumn migration was investigated at two widely different latitudes, in Sweden and in Kenya, by cage experiments in manipulated magnetic fields during the twilight period after sunset. The objective was to compare responses by birds exposed to different geomagnetic conditions, particularly to the shift in magnetic inclination between the northern a
I study the economic returns to migration among Swedish immigrants in the United States in 1900 and 1910, by social class. Using linked data from full-count Swedish and US censuses via the Swedish Emigrant Register, I first estimate the rates of return to migration using two identification strategies, with the returns exceeding 60 percent, notably higher for migrants from lower social classes. Fur
This paper examines how India’s national urban development agenda is reshaping relationships between national, State and city-level governments. Jawaharlal Nehru National Urban Renewal Mission, the flagship programme that heralded a new era of urban investment in India, contained a range of key governance aspirations: linking the analysis of urban poverty to city-level planning, developing holisti
Expanded state-subsidised housing programmes in middle-income countries raise questions about the displacement and socio-spatial marginalisation of poor households. Examining these questions through people’s experiences of resettlement indicates the importance of mobility to their lives. Drawing on a mixed-method comparative study of Ahmedabad, Chennai and Johannesburg, we ask: How does the reloca
