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BACKGROUND: HLA-DR4, a common antigen of HLA-DRB1, has multiple subtypes that are strongly associated with risk of type 1 diabetes (T1D); however, some are risk neutral or resistant. The pathobiological mechanism of HLA-DR4 subtypes remains to be elucidated.METHODS: We used a population-based case-control study of T1D (962 patients and 636 controls) to decipher genetic associations of HLA-DR4 subt
This article is about how negative discourses of teacher education position teacher educators and how they might influence or inspire action. We use self-study methods to investigate the political dimension of teacher education in two national contexts: Sweden and the USA. More specifically, we examine the emotions stirred by the positioning related to being a teacher educator and how those emotio
We present experimental intrinsic loss power (ILP) values, measured at an excitation frequency of 1 MHz and at relatively low field amplitudes of 3.4–9.9 kA/m, as a function of the mean core diameter, for selected magnetic nanoparticles (MNPs). The mean core sizes ranged from ca. 8 nm to 31 nm. Transmission electron microscopy indicated that those with smaller core sizes (less than ca. 22 nm) were
The Russian war of aggression against Ukraine caused an escape of >7 million people to other European countries. In this extreme context, the accommodation of refugees has been an urgent need and an unexpected challenge for the host cities and societies. This short paper discusses insights and learnings on housing and accommodation of Ukraine war refugees at the local scale. It summarises challeng
BACKGROUND: Public health policies and healthcare quality play a pivotal role on the health outcome level and disparities across sociodemographic groups. However, there is little evidence on their role on disparities in life expectancy (LE) and life disparity (LD) in low and middle income countries. The present study aimed to assess the contributions of avoidable mortality, as a measure of inter-s
Objectives: In this study, we apply a clustering method to proteomic data sets from bovine and human models of post-traumatic osteoarthritis (PTOA) to distinguish clusters of proteins based on their kinetics of release from cartilage and examined these groups for PTOA biomarker candidates. We then quantified the effects of dexamethasone (Dex) on the kinetics of release of the cartilage media prote
Land cover and land use is well known to be one of the main drivers of erosion and soil loss. However, most findings rely on short-term data analysis and focus on only one or two land covers. In our paper we investigate the long-term trade-off between common agricultural land cover changes (sugarcane, pasture, and soybean) and their runoff and soil loss rates, as well as comparing them to forest (
Purpose:The objective of the paper is to explore the relationship among perceived quality value, hedonic value, social value, price value, customer engagement and customer-based brand equity using stimulus-organism-response (S-O-R), customer engagement and customer-perceived value theories for digital payment apps. In addition, the study examines the mediating role of customer engagement between c
To investigate the association between chronic inflammatory rheumatic diseases (CIRD) and drug use disorder (DUD). Individuals aged ≥ 30 years in 2009 that met the following conditions were included: residing in the Skåne region, Sweden, with at least one healthcare contact in person and no history of DUD (ICD-10 codes F11-F16, F18-F19) during 1998–2009 (N = 649,891). CIRD was defined as the prese
Surgery for benign nerve tumours is performed for pathoanatomical diagnosis and symptomatic relief, but might cause residual problems. We aimed to assess patient-reported symptoms and disability before and after surgery at a national level. In total, 206 cases surgically treated for a benign peripheral nerve tumour 2010–2019 registered in the Swedish Quality Registry for Hand Surgery (HAKIR; respo
The activity-regulated cytoskeleton-associated (Arc) protein is essential for synaptic plasticity and memory formation. The Arc gene, which contains remnants of a structural GAG retrotransposon sequence, produces a protein that self-assembles into capsid-like structures harboring Arc mRNA. Arc capsids, released from neurons, have been proposed as a novel intercellular mechanism for mRNA transmissi
Background: Orthostatic hypotension (OH) has been associated with elevated risk of cardiovascular diseases (CVDs) and dementia risk. To better understand the OH-dementia association, we assessed the associations of OH with CVD and subsequent dementia in older adults and considered the temporality of CVD and dementia onset. Methods: This 15-year population-based cohort study included, at baseline,
Industry 4.0 (I4.0) is an emerging concept describing the business setting application of a broad set of digitalisation technologies, connectivity, and automation. The most common critical infrastructure (CI) uses Industrial Control Systems (ICS) for operation and supervisory control. However, the Supervisory Control and Data Acquisition (SCADA) and Internet of things (IoT) systems are examples of
Background/Aims Self-rated health before, during and after pregnancy is important for women s quality of life and promotes bonding between mother and child. However, diverse aspects of care models influence women s experiences during pregnancy. This study aimed to investigate low?risk women s self-rated health during the perinatal period in relation to different models of care in Sweden. Methods A
While prior research has gleaned important insight into consumers’ social media engagement, an important literature-based tension exists that warrants further attention. On the one hand, females are increasingly empowered (e.g., through their rising spending power). On the other hand, advertising-based gender stereotypes persist, thus limiting female consumers’ empowerment and decelerating adverti
Compound optimization of distributed energy systems, urban morphology, and the transportation network is crucial to improving the robustness of interconnected urban energy infrastructures and enhancing their resilience to extreme climate events. Available methods and tools mainly focus on optimizing one component in urban areas and fail to consider complex interactions in interconnected infrastruc
