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Subfossil remains of Cannabis sativa L. (hemp) have been found at Lindangelund in the region of Malmo, southern Sweden. These represent the earliest robust evidence so far for hemp retting in Scandinavia. Finds of seeds, stems and pollen of C. sativa from a waterlogged context on a settlement dating to the Roman Iron Age demonstrate that the plant was locally cultivated and processed during the 1s
Bone marrow-derived mesenchymal stem cells (MSCs) are dominant seed cell sources for bone regeneration. Bone morphogenetic proteins (BMPs) initiate cartilage and bone formation in a sequential cascade. Vascular endothelial growth factor (VEGF) is an essential coordinator of extracellular matrix remodeling, angiogenesis and bone formation. In the present study, the effects of the vascular endotheli
Negative pressure wound therapy (NPWT) alters wound edge microvascular blood flow. Some preclinical data suggest that cycling between low and high negative pressure may be more beneficial than continuous NPWT. The purpose of this in vivo study was to compare the effect of intermittent negative pressure (cycled either from 0 to -75 or to -125 mm Hg) and variable negative pressure (cycled from -10 t
Calcitonin gene-related peptide (CGRP) receptor antagonists have demonstrated anti-migraine efficacy. One remaining question is where do these blockers act? We hypothesized that the trigeminal ganglion could be one possible site. We examined the binding sites of a CGRP receptor antagonist (MK-3207) and related this to the expression of CGRP and its receptor in rhesus trigeminal ganglion. Pituitary
We demonstrate the reversible intercalation of CO between a hexagonal boron nitride (h-BN) monolayer and a Rh(111) substrate above a threshold CO pressure of 0.01 mbar at room temperature. The intercalation of CO results in the flattening of the originally corrugated h-BN nanomesh and an electronic decoupling of the BN layer from the Rh substrate. The intercalated CO molecules assume a coverage an
Intercellular and covalently bound lipids within the stratum corneum (SC), the outermost layer of the epidermis, are the primary barrier to cutaneous water loss (CWL) in birds. We compared CWL and intercellular SC lipid composition in 20 species of birds from desert and mesic environments. Furthermore, we compared covalently bound lipids with CWL and intercellular lipids in the lark family (Alaudi
Background and purpose: The Radiation Oncology Safety Information System (ROSIS) was established in 2001. The aim of ROSIS is to collate and share information on incidents and near-incidents in radiotherapy, and to learn from these incidents in the context of departmental infrastructure and procedures. Materials and methods: A voluntary web-based cross-organisational and international reporting an
Wang Y, Roller J, Slotta JE, Zhang S, Luo L, Rahman M, Syk I, Menger MD, Thorlacius H. Distinct patterns of leukocyte recruitment in the pulmonary microvasculature in response to local and systemic inflammation. Am J Physiol Lung Cell Mol Physiol 304: L298-L305, 2013. First published December 28, 2012; doi:10.1152/ajplung.00246.2012.The mechanisms of leukocyte recruitment in the pulmonary microvas
Prediction of radiographic progression (RP) in early rheumatoid arthritis (eRA) would be very useful for optimal choice among available therapies. We evaluated a multi-biomarker disease activity (MBDA) score, based on 12 serum biomarkers as a baseline predictor for 1-year RP in eRA.
Allocation trade-offs of carotenoids between their use in the immune system and production of integumentary colouration have been suggested as a proximate mechanism maintaining honesty of signal traits. We tested how dietary carotenoid supplementation, immune activation and immune suppression affect intensity of coccidian infection in captive greenfinches Carduelis chloris, a passerine with carote
The CD24 glycoprotein is a mediator of neuronal proliferation, differentiation and immune suppression in the normal CNS, and a proposed cancer biomarker in multiple peripheral tumor types. We performed a comparative analysis of CD24 gene expression in a large cohort of pediatric and adult brain tumors (n = 813), and further characterized protein expression in tissue sections (n = 39), primary brai
The concept of the agnostoid arthropod species Lotagnostus americanus (Billings, 1860), which has been reported from numerous localities in the upper Furongian Series (Cambrian) of Laurentia, Gondwana, Baltica, Avalonia, and Siberia, is reviewed with emphasis on morphologic and taphonomic information afforded by large collections from Hunan in South China, Xinjiang in Northwest China, and Zhejiang
Existing research shows that corporate climate actions are the result of public policies and a limited range of other factors that can influence business strategy. Managers are depicted as lacking agency in that they passively adhere to "drivers" of climate actions, with little room for autonomy. This study takes issue with such a view by examining agency vis-a-vis managers' temporal orientations.
Treatment of Ph2PC2H4SC2H4SC2H4PPh2 (PSSP) with [Os-3(CO)(11)(NCMe)] under mild conditions yields [{Os-3(CO)(11)}(2)(mu-PSSP)], 1, and [Os-3(CO)(11)(PSSP)], 2. In cluster 1 the ligand links two trinuelear cluster subunits, coordinating via its phosphine moieties. In cluster 2, the ligand is coordinated through one of the phosphine groups, while the remaining part of the PSSP ligand is oriented in
Apixaban is an oral direct factor Xa inhibitor developed for prophylaxis and treatment of thromboembolic disorders. Laboratory monitoring is not necessary, but the effects on common coagulation reagents and assays are clinically valuable information.
The gradual disappearance of tropical animal species due to overhunting and habitat loss represents a major risk for biodiversity and tropical rainforest conservation efforts. Uncontrolled hunting and other human-induced declines in diversity and abundance of seed-dispersing animal species might also negatively affect biomass carbon storage, which could undermine climate change mitigation efforts.
The neuroprotective properties of cystamine identified in pre-clinical studies have fast-tracked this compound to clinical trials in Huntington's disease, showing tolerability and benefits on motor symptoms. We tested whether cystamine could have such properties in a Parkinson's disease murine model and now provide evidence that it can not only prevent the neurodegenerative process but also can re
