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Objectives. To establish the gender difference amongst newly diagnosed type 1 diabetic patients aged 15-34 years, considering age at diagnosis, temporal trend and seasonal variation at time of diagnosis. Study design. A population-based prospective study with a mean annual population at risk of 2.3 million. Setting. All departments of medicine, endocrinology and paediatrics and primary health care
Dynamic chromatin structure is a fundamental property of gene transcriptional regulation, and has emerged as a critical modulator of physiological processes during cellular differentiation and development. Analysis of chromatin structure using molecular biology and biochemical assays in rare somatic stem and progenitor cells is key for understanding these processes but poses a great challenge beca
Psychiatric and metabolic features appear several years before motor disturbances in the neurodegenerative Huntington's disease (HD), caused by an expanded CAG repeat in the huntingtin (HTT) gene. Although the mechanisms leading to these aspects are unknown, dysfunction in the hypothalamus, a brain region controlling emotion and metabolism, has been suggested. A direct link between the expression
Pathogenic microbes acquire the human plasma protein plasminogen to their surface. In this article, we characterize binding of this important coagulation regulator to the respiratory pathogen nontypeable Haemophilus influenzae and identify the Haemophilus surface protein E (PE) as a new plasminogen-binding protein. Plasminogen binds dose dependently to intact bacteria and to purified PE. The plasm
Structural and electronic properties of TiO2 nanoparticles sensitized with a set of RuII(tpy)(2) based dyes have been investigated using density functional theory (DFT) calculations combined with time-dependent (TD) DFT calculations. The effects of carboxylic and phosphonic acid anchor groups, as well as a phenylene spacer group, on the optical properties of the dyes and the electronic interaction
As foreign aid money is continually spent in developing countries, it is incumbent that international aid organizations work towards improving the effectiveness of their projects. In the setting and context of disaster risk reduction and disaster recovery projects, this thesis aims to understand how foreign aid organizations can make Honduran communities less dependent on foreign aid through speci
With a current financial crisis and a tough competitive environment, all units and departments within the companies have to keep up with the market and its demands. Every time Sandvik sells a machine to a mining company, the buyer faces the fact that they normally have to educate their operators from scratch. This, implicitly, means a period with high risks of failures and mistakes. Training with
In The Girl with the Dragon Tattoo, Stieg Larsson depicts a fiery, independent and highly sexual protagonist in the character of Lisbeth Salander. While many readers fail to notice the subtle reference to Lisbeth’s natural red hair, this quality, along with Larsson’s admittance that his inspiration originated from Astrid Lindgren’s Pippi Longstocking, situates Lisbeth in a long tradition of redhea
Gränser mellan vegetationszoner fascinerar genom att på ett tydligt sätt påminna oss om sambanden som finns mellan det som lever och dess miljö. En av de mest påtagliga gränserna är den alpina trädgränsen, där fjällbjörkskogen gradvis övergår till kalfjäll. Den karga miljön som utgör kalfjället är starkt kopplat med temperatur och klimatförändringens ökade temperatur har medfört förändringar i träAerial photo interpretation shows a recent densification of trees has been occurring between 1960 and 2009 in the mountain birch (Betula pubescens ssp. czerepanovii) forest of the treeline ecotone in northern Swedish mountains. The correlation between treeline position and annual temperature is commonly accepted and advancing treelines are considered to be a useful indicator for monitoring climate
Sera from 79 patients with acute self-limiting hepatitis, 17 patients with acute hepatitis B evolving into chronic HBsAg carriership, and 43 chronic HBsAg carriers without a history of acute hepatitis were analyzed for presence of hepatitis B virus (HBV)-DNA by a molecular hybridization technique. In acute self-limiting hepatitis, HBV-DNA was cleared within a few weeks after the onset of clinical
Methods currently used for surface display on insect cells and budded baculovirus, all utilize the sequences from class I transmembrane proteins. This gives rise to some problems when handling unknown genes or cDNAs encoding full-length proteins. First, the stop codon from the cloned gene will be located upstream of the sequence for the transmembrane region. Second, the chance of getting the seque
AIMS: To study the prevalence of airway obstruction according to age, gender and smoking habits using spirometry, and to compare the results using different definitions, classifications and spirometric reference values in an elderly population. METHODS: A random sample of 2046 men and women in nine age cohorts (aged 60, 66, 72, 78, 81, 84, 87, 90 and 93 years) were drawn from the Swedish municipal
In this essay, I focus on the influences Bradley has used to construct her historical setting, specifically the pre-Christian religion that she describes in the novel. I have studied Bradley's use of Margaret Murray's theories, and how it affects the religious message of the novel.
Many selection methodologies and tools have been developed in attempts to make recruitment processes more accurate and to improve objectivity in this area. However, these methods and tools can only improve objectivity to the extent that they are not affected by unconscious feelings, or implicit processes used by the recruiter. The purpose of this study is to try to discover in what way intuition s
Small- and Medium-sized enterprises (SMEs) contributed a lot to the economic growth and promote employment in China. However, they were suffering from the credit discrimination, insecure property right protection, lack of the industry support policy and social services the same time. Based on this general background, in 2003, the Law of the PRC on promotion of Small and Medium-sized Enterprises (S
Background: A prediction model that estimates survival and neurological outcome in out-of-hospital cardiac arrest patients has the potential to improve clinical management in emergency rooms. Methods: We used the Swedish Registry for Cardiopulmonary Resuscitation to study all out-of-hospital cardiac arrest (OHCA) cases in Sweden from 2010 to 2020. We had 393 candidate predictors describing the cir
