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PURPOSE OF REVIEW: The purpose of this review is to provide a comprehensive evaluation of the most important type 2 diabetes gene to date, transcription factor 7 like-2. RECENT FINDINGS: An important step to find genetic causes of type 2 diabetes in 2006 was the identification of the fact that variants in the gene encoding transcription factor 7 like-2 reproducibly increase susceptibility to type
The np P Rydberg sequence of neutral Ytterbium is strongly perturbed. These perturbations were monitored by measuring the g(J) factors and lifetimes of 19 states, including both singlets and triplets as well as states from the perturbing configurations. A pulsed laser setup was used. The g(J) factors were obtained from a Zeeman quantum-beat experiment and the lifetimes by direct observation of the
The classical connectionist models are not well suited to working with data varying over time. According to this, temporal connectionist models have emerged and constitute a continuously growing research field. In this paper we present a novel supervised recurrent neural network architecture (SARASOM) based on the Associative Self-Organizing Map (A-SOM). The A-SOM is a variant of the Self-Organizi
Manganese (Mn) is an essential nutrient in humans, but excessive exposure to Mn may cause neurotoxicity. Despite homeostatic regulation, Mn concentrations in blood vary considerably among individuals. We evaluated if common single-nucleotide polymorphisms (SNPs) in SLC30A10, which likely encodes a Mn transporter, influence blood Mn concentrations and neurological function. We measured blood Mn con
Abstract in German Sogenannte sexuelle Minderheiten haben in Kanada grundlegende Veränderungen ihres rechtlichen und gesellschaftlichen Status erarbeitet. Zumindest bis in die 1960er Jahre galten schwule Männer auf Grund ihrer ‘Tendenzen’ als Gefahr für die nationale Sicherheit und als leichte Beute für (kommunistische) Erpressung. Gegenwärtig ermöglicht die kanadische Gesetzgebung die Ehe für gle
Ninety-eight patients, 56 suffering according to DSM-IV of unipolar depression and 42 of somatoform disorders, were compared on the Beck Depression Inventory (BDI) total scale, the subscale of Somatic complaints and the Cognitive-affective subscale. A factor analysis performed on the total group revealed five factors used to determine new subscales: Depressed mood, Somatic manifestations, Loss of
Introduction: Chronic pain is among the most common side effects of cancer in cancer patients and survivors, often co-occurring with fatigue, emotional distress and elevated fears of cancer recurrence. Both pain and the associated difficulties are associated with poorer outcomes. Longitudinal studies are needed that identify psychosocial factors that mitigate the effects of chronic cancer-related
Background: Approximately 40% of cancer patients/survivors develop chronic cancer-related pain (CRP), which is often associated with greater levels of fatigue and cancer worry, all of which are associated with poorer functioning, wellbeing, and greater healthcare costs. Psychological Flexibility (PF) refers to one’s level of openness to and acceptance of physical/emotional experiences and willingn
Black carbon (BC) is an air pollutant of emerging concern, and further evidence is needed to understand its health effects. This study investigates the association between gestational BC exposure and birth outcomes, and whether these effects are independent of particulate matter with an aerodynamic diameter of ≤ 2.5 μm (PM2.5) exposure. We used data from the population-based birth cohort, Maternal
Memory functions are susceptible to age-related cognitive decline, making it essential to explore the underlying neurophysiological mechanisms that contribute to memory function during healthy ageing. Resting-state EEG (rsEEG) parameters, particularly the aperiodic exponent, a marker of cortical excitation-inhibition balance, and individual alpha peak frequency, a correlate of neural processing ef
What was the function of monarchy when the monarch had none? After the death of Sweden's King Charles XII in 1718, absolutism was abolished, and the new Constitution reduced the monarch to a mere figurehead. The monarchy nevertheless continued to be an indispensable part of the political system. This book explains the role of the king in the politics of the Age of Liberty (1718–1772), exploring th
Takotsubo syndrome (TTS) is an acute, reversible form of left ventricular dysfunction, typically triggered by emotional or physical stress. The hallmark feature is reversible regional wall motion abnormality extending beyond a single coronary distribution, most commonly presenting with an apical ballooning pattern. The pathophysiology is multifactorial, encompassing neurohormonal dysregulation, ca
Conceptualising public authority as continually performed, this paper traces the interplay between modes of legitimation, state capacity and scalar politics in governing the COVID-19 pandemic. Despite attempts to unify COVID responses nationally, governance practices differed across India’s cities: Ahmedabad (Gujarat) heightened policing, Thiruvananthapuram (Kerala) engaged its decentralised gover
Introduction: Being stigmatized because of one's weight can pose physical, mental, and social challenges. While weight stigma and its consequences are established throughout Europe, North America, and Australasia, less is known about weight stigma in other regions. The objective of this study was to identify the extent and focus of weight stigma research in Latin America, Asia, the Middle East, an
