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To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two showing sex-differentiated association. Genomewide analyses of these data
While interplay between BRCA1 and AURKA-RHAMM-TPX2-TUBG1 regulates mammary epithelial polarization, common genetic variation in HMMR (gene product RHAMM) may be associated with risk of breast cancer in BRCA1 mutation carriers. Following on these observations, we further assessed the link between the AURKA-HMMR-TPX2-TUBG1 functional module and risk of breast cancer in BRCA1 or BRCA2 mutation carrie
In high-energy collisions, the spatio-temporal size of the particle production region can be measured using the Bose-Einstein correlations of identical bosons at low relative momentum. The source radii are typically extracted using two-pion correlations, and characterize the system at the last stage of interaction, called kinetic freeze-out. In low-multiplicity collisions, unlike in high-multiplic
Factor I (FI) is a serine protease that inhibits the complement system by cleaving activated C3 and C4 complement proteins, in the presence of cofactors. Mutations in the gene coding for FI have been identified in complete FI deficient- and atypical hemolytic uremic syndrome (aHUS) patients. The mutations were introduced in recombinantly expressed proteins, purified and analyzed in functional ass
Objectives The systemic vasculitides are multiorgan diseases where early diagnosis and treatment can significantly improve outcomes. Robust nomenclature reduces diagnostic delay. However, key aspects of current nomenclature are widely perceived to be out of date, these include disease definitions, classification and diagnostic criteria. Therefore, the aim of the present work was to identify defici
Leuprolide is a gonadotropin-releasing hormone (GnRH) analog which has been shown to reduce symptoms in patients with irritable bowel syndrome (IBS) and chronic intestinal pseudo-obstruction (CIPO). The mechanism is not known, but one hypothesis is through down-modulation of luteinizing hormone (LH) secretion, a hormone whith antagonistic effect on gastrointestinal motility. However, presence of L
An existence and stability theory for solitary water waves with weak surface tension has recently been given by Buffoni (2005, 2009) [2,3]. The theory, which is variational in nature, relies upon the assumption that the infimum of the variational functional is strictly subhomogeneous with respect to a small parameter. In this Note we rigorously establish the relevant strict-subhomogeneity property
We investigate the influence of the one-dimensional character of the phonon modes in a catalytically grown GaAs nanowire on the absorption spectrum of an embedded quantum dot, focusing on the on the contribution from the piezoelectric coupling. In general, the reduced dimensionally of the phonons leads to spectral side peaks and a zero-phonon line broadening due to the energetically lowest (acoust
Fetal cardiotocography is characterized by low specificity; therefore, in an attempt to ensure fetal well-being, fetal scalp blood sampling has been recommended by most obstetric societies in the case of a non-reassuring cardiotocography. The scientific agreement on the evidence for using fetal scalp blood sampling to decrease the rate of operative delivery for fetal distress is ambiguous. Based o
In the large majority of product development projects, computer-based design analyses are performed to assess the feasibility of potential technical solutions. As a first step to bring about a deeper understanding of the interactions between the engineering design and the design analysis activities, a survey has been performed in industry. The results of the survey cover: the use of design analysi
The structures of interfacial layers formed from mixtures of comb polymers, comprising a high charge density cationic backbone and poly(ethylene oxide) (PEO) side-chains, with the anionic surfactant sodium dodecyl sulfate (SDS) at the silica/water interface, have been determined using neutron reflectivity measurements. The use of mixtures in which only the isotopic composition of the surfactant is
A likelihood-based discriminant for the identification of quark- and gluon-initiated jets is built and validated using 4.7 fb of proton-proton collision data at collected with the ATLAS detector at the LHC. Data samples with enriched quark or gluon content are used in the construction and validation of templates of jet properties that are the input to the likelihood-based discriminant. The discrim
Bengt Holmberg is widely known and respected as one of the pioneers of the sociological study of the New Testament. His dissertation, Paul and Power, published by CWK Gleerup in 1978 and by Fortress Press in 1980, was among the first studies to use sociological theory to explore and more deeply understand the Pauline letters, and it set the agenda for much future research. Partly on the basis of h
Diet and health during the Late Neolithic and Early Bronze Age Scandinavia have never been under systematic study. Still, high statures have been reported from osteologists, statures that indicate good health. This article is based on a pilot study examining health changes in relation to dietary changes due to intensified agriculture and the possible Secondary Products Revolution as discussed by S
The aim was to translate the Parental Stressor Scale: Neonatal Intensive Care Unit (PSS: NICU) into the Swedish language and to evaluate the psychometric properties of the Swedish version.
Resonant inelastic soft X-ray scattering at the 3p resonances in crystalline Ge is presented. Both stationary and dispersive features are observed in a wide energy range above as well as below the ionization limits. These observations are in agreement with theoretical predictions based on a two-step model where the initially excited electron has no influence on the emission step. Excess population
This article explores construction, production and distribution of environmental information in social media. Specifically, the focus is on people's accounts in social media of their everyday life practices aimed at leading what are considered environmentally friendly lives. The article seeks to establish how through the reproduction of alignments of certain everyday and domestic practices with en
