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Background: Artificial intelligence (AI) systems can potentially aid the diagnostic pathway of prostate cancer by alleviating the increasing workload, preventing overdiagnosis, and reducing the dependence on experienced radiologists. We aimed to investigate the performance of AI systems at detecting clinically significant prostate cancer on MRI in comparison with radiologists using the Prostate Im
Background: Eslicarbazepine acetate (ESL) is a new anti-epileptic drug (AED) chemically related to oxcarbazepine (OXC) and carbamazepine (CBZ) and is increasingly used in clinical practice. The purpose of the study was to investigate 2-way pharmacokinetic interactions between ESL and other AEDs as compared to OXC and CBZ. Methods: Anonymous data regarding age, gender, use of AEDs, daily doses and
With the wave of right-wing populist parties coming to power and gaining influence in recent years, civil society has been hit by increased ideological resistance from outside. The paper explores how key civil society actors react to policy changes by national governments influenced by right-wing populist parties. The aim is to understand how the rise to power of right-wing populist parties affect
The addition of metal intercalants into the van der Waals gaps of transition metal dichalcogenides has shown great promise as a method for controlling their functional properties. For example, chiral helimagnetic states, current-induced magnetization switching, and a giant valley-Zeeman effect have all been demonstrated, generating significant renewed interest in this materials family. Here, we pr
Glucocorticoid resistance is commonly observed in depression, and has been linked to reduced expression and/or function of the glucocorticoid receptor (NR3C1 in human, hereafter referred to as GR). Previous studies have shown that GR-mutant zebrafish exhibit behavioural abnormalities that are indicative of an affective disorder, suggesting that GR plays a role in brain function. We compared the br
Each year, about 30% of all newly diagnosed cancer cases in women worldwide are breast cancers [1]. One of the most common techniques for breast cancer diagnosis is mammography. However, this technique provides limited functional information regarding breast tissue morphology. In cases of suspected malignancy invasive techniques such as biopsy are implemented.In this work an optical deep tissue im
Our study aims to investigate the relationship between social participation and loneliness among Chinese older adults and examine how their views of social change moderate the strength of this relationship. The cross-sectional nationwide data from the China Longitudinal Aging Social Survey (CLASS) was used. Results show that increased online participation and community participation were associate
We propose the Virtual Bingo Blower (VBB) as a way to generatecredible risk and ambiguity in computerized experiments. Using aphysics engine—a computer simulation of a physical system—the VBBsimulates a conventional bingo blower. Different aspects of the VBB,such as the number of balls, their color, and their speed, can be easilymodified. In an online experiment, we measure ambiguity attitudes and
The terms ‘informal sector’ and ‘shadow economy’ are in vogue but remain conceptually fuzzy in what they measure or mean. They are used in tax research and policy but with many assumptions, leading to poorly designed policies that lead to further immiseration of those who derive their livelihoods informally. Focusing on Sub-Saharan Africa, I critically interrogate the current conceptualisation of
Uridine residues present at the wobble position of eukaryotic cytosolic tRNAs often carry a 5-carbamoylmethyl (ncm5), 5-methoxycarbonylmethyl (mcm5), or 5-methoxycarbonylhydroxymethyl (mchm5) side-chain. The presence of these side-chains allows proper pairing with cognate codons and they are particularly important in tRNA species where the U34 residue is also modified with a 2-thio (s2) group. The
Breast cancer is the most frequently diagnosed cancer in females globally. However, we know relatively little about trends in males. This study describes United Kingdom (UK) secular trends in breast cancer from 2000 to 2021 for both sexes. We describe a population-based cohort study using UK primary care Clinical Practice Research Datalink (CPRD) GOLD and Aurum databases. There were 5,848,436 elig
Purpose: The aim of the study is to investigate the association between serum levels of cortisol and erectile function in healthy men aged 45-60 years.Material and methods: The serum level of cortisol was measured. The international index of erectile function-5 items (IIEF-5) was used to assess the erectile function.Data were gathered on the age of participants, Body Mass Index (BMI), waist circum
We present data on molluscan fauna within the L3 loess unit (and partially within the S3 paleosol) from the key loess section of Veliki Surduk in Serbia. The section correlates to Marine Isotope Stage (MIS) 8 and late MIS 9 and, thus, spans the time frame from ~350 to 250 ka. The Veliki Surduk loess–paleosol sequence (LPS) is located on the northwestern margin of the Titel loess plateau and compri
Common wall lizards (Podarcis muralis) in Italy show a striking variation in body coloration across the landscape, with highly exaggerated black and green colors in hot and dry climates and brown and white colors in cool and wet climates. Males are more intensely colored than females, and previous work has suggested that the maintenance of variation in coloration across the landscape reflects clim
Smallholder farmers are widely touted as essential to sustainable agricultural development in sub-Saharan Africa and beyond. But what exactly is meant by sustainable development, and how are smallholder farmers expected to contribute to it? In this perspective, we describe and assess two competing visions of sustainable development, namely Capital Theory and the Capabilities approach, paying speci
The aerobic oxidation of carbon monoxide to carbon dioxide is catalysed by the Mo/Cu-containing CO-dehydrogenase enzyme in the soil bacterium Oligotropha carboxidovorans, enabling the organism to grow on the small gas molecule as carbon and energy source. It was shown experimentally that silver can be substituted for copper in the active site of Mo/Cu CODH to yield a functional enzyme. In this stu
This open access book brings together experts from both EU competition law as well fundamental rights backgrounds, discussing the most recent developments in EU legislation on digitalisation. Most prominently, it explores the recently introduced Digital Markets Act (DMA), including a discussion on other related legislative acts and the respective case law. It is aimed mostly at academics and resea
