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Sizing of borehole heat exchangers (BHEs) for direct ground cooling systems (DGCSs) is a critical part of the overall system design. This study investigates the thermal performance and sizing of a DGCS with two different operation strategies using experimental and simulation approaches. The traditional on/off operation strategy keeps a constant room temperature. The continuous operation strategy h

Gliomas are the most common intracranial primary tumors, for which very few therapeutic options are available. The most malignant subtype is the glioblastoma, a disease associated with a 5-year survival rate lower than 5%. Given that research in glycobiology continues highlighting the role of glycans in tumor cell biology, it offers an interesting niche for the search of new therapeutic targets. I

In this preview of the introduction of the special issue of the AILA Review (Volume 34, Number 1), we focus on developing shared languages in and across domains and professional settings. The relation and collaboration between researchers and practitioners has long been discussed within and across applied sciences and theoretical disciplines, mainly in the framework of transdisciplinarity (see AIL

Drawing on participatory action research conducted in Sierra Leone, Kosovo and the Philippines, Human Rights in Prisons analyses encounters between rights-based non-governmental organisations and prisons. It explores the previously under-researched perspectives of prison staff and prisoners on their lives and relationships.

We test for age and metallicity gradients in the Galactic Bulge between the two low extinction windows Baade's window (l = 1°.1 b = -4°.8) and Sagittarius-I (l = 1°.3 b = -2°.7). We derive a metallicity difference of ≤ 0.2 dex between BW and SGR-I window. This corresponds to a metallicity gradient of 1.3 dex kpc-1. This steep gradient is reconcilable with the existence of a short scale length inne

Recent advances in proteomic technologies have made high throughput profiling of low abundance proteins in large epidemiological cohorts increasingly feasible. We investigated whether aptamer-based proteomic profiling could identify biomarkers associated with future development of type 2 diabetes (T2DM) beyond known risk factors. We identified dozens of markers with highly significant associations

Over the last decade, representations of the rainbow were repeatedly disputed in Poland, revealing the country’s ongoing socio-political changes and its drift away from the generally liberal and secular values of the European mainstream. These cases show a political growth and an increasing social diffusion of Polish ‘national paleoconservatism.’ The aim of this article is to (1) discuss the intel

ABSTRACT: The burden of pain in newborn infants has been investigated in numerous studies, but little is known about the appropriateness of the use of pain scales according to the specific type of pain or infant condition. This systematic review aimed to evaluate the reporting of neonatal pain scales in randomized trials. A systematic search up to March 2019 was performed in Embase, PubMed, PsycIN

This study examines the interdependence between R&D resources, coopetitive performance and extent of cooperation in development-related standardization settings that involve network effects. Coopetitive performance is measured as the firm’s influence on the change process of standards. Cooperation is measured as the number of firm technology partners in influencing industry technology standard

Background: Smoking is reported to affect the risk of a number of chronic disorders, including rheumatic diseases. Previous cross-sectional studies have shown a lower frequency of smoking in patients with primary Sjögren's syndrome (pSS). The aim of this study was to investigate the impact of smoking and socioeconomic status on the risk of subsequent diagnosis of pSS in a nested case-control study

Many zoonotic diseases have birds as their natural hosts. Waterfowl are the natural hosts of avian influenza viruses (AIVs) and most avian influenza infections of wild birds appear mild, with infected inviduals displaying no or few symptoms. It is clear that the epidemiology of avian influenza cannot be fully understood without taking the ecology of its hosts into account. However, large scale stu

One of the principal biostratigraphical tools used in the lower Palaeozoic, and especially the Cambrian System, is trilobites. Historically, both polymerids and agnostoids have commonly been included as 'trilobite' groups, although currently the question of whether they comprise a monophyletic group or are polyphyletic is unsettled. Beginning in the late 1800s, the base of the Cambrian System was

The modern science system relies on intense evaluation of scientific publication, in which scientific impact is highly emphasized, but its contribution to the progress of science has been controversial. Focusing on two aspects of the science system, resource allocation and academic career design, this study explores whether these policies, presumably aiming at high-impact research, actually achiev

In disease dynamics, high immune gene diversity can confer a selective advantage to hosts in the face of a rapidly evolving and diverse pathogen fauna. This is supported empirically for genes involved in pathogen recognition and signalling. In contrast, effector genes involved in pathogen clearance may be more constrained. b-Defensins are innate immune effector genes; their main mode of action is

Lipid analysis performed by high performance thin layer chromatography (HPTLC) is a relatively simple, cost-effective method of analyzing a broad range of lipids. The function of lipids (e.g., in host-pathogen interactions or host entry) has been reported to play a crucial role in cellular processes. Here, we show a method to determine lipid composition, with a focus on the cholesterol level of pr

Nano and micro structured thin (μ m-scale) foils were designed, fabricated and irradiated with the high intensity laser system operating at LLC (Lund Laser Centre, Sweden) in order to systematically study and improve the main proton beam parameters. Nano-spheres deposited on the front (laser irradiated) surface of a flat Mylar foil enabled a small enhancement of the maximum energy and number of th

Mitochondria produce ATP via respiratory oxidation of organic acids and transfer of electrons to O2 via the mitochondrial electron transport chain. This process produces reactive oxygen species (ROS) at various rates that can impact respiratory and cellular function, affecting a variety of signaling processes in the cell. Roles in redox signaling, retrograde signaling, plant hormone action, progra