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Popular Abstract in Swedish Min avhandling består av sex delarbeten som redovisar olika undersökningar av ett värmestabilt enzym (xylanas). Detta enzym är isolerat från en bakterie (Rhodothermus marinus) som lever i varma källor (vid 55-77 °C) och enzymet förväntas alltså fungera vid dessa temperaturer. Enzymets uppgift i bakterien är att förse den med lagom långa kolhydratmolekyler som bakterien A gene encoding a multidomain xylanase from the thermophilic bacterium Rhodothermus marinus has been cloned, sequenced and produced in Escherichia coli . The gene product was found to be a 109 kDa protein consisting of five domains. The catalytic domain and the two polysaccharide binding domains (PBD, previously called carbohydrate binding domains) have been cloned and produced separately for func

The aerodynamics and kinematics behind the flight of animals are relatively unknown. Although animal flight has been studied for several hundreds of years, it is only in recent time that we have the technical abilities to study the mechanistic basis of animal flight. This thesis represents an attempt to widen the knowledge about animal flight by studying one of the most advanced flyers of the natu

A growing body of research suggests that a firm’s governance system can significantly impact the long-term value creative potential of an enterprise by disciplining and encouraging organizational efforts to pursue risky entrepreneurial projects. Following this stream of research, we present a study of the impact of ownership and board governance on entrepreneurship in small technology-based firms.

Within a UN Joint Programme titled “Enhancing the Capacity of Turkey to Adapt to Climate Change” a systems approach workshop was carried out in Adana, Turkey with broad stakeholder participation. The participants applied systems thinking approach, causal loop diagramming methodology and systems analysis to examine the potential impacts of projected climatic changes on natural ecosystems and socio-

Popular Abstract in Swedish Ledgångsreumatism (reumatoid artrit) är en allvarlig inflammatorisk led- och systemsjukdom som drabbar ungefär 1% av befolkningen. Den är sannolikt den vanligaste behandlingsbara orsaken till invaliditet i västerlandet. Under de senaste 10 åren har allt fler forskare uppmärksammat sjukdomens dåliga prognos och manat till en tidigare och mera effektiv behandling så snartRheumatoid arthritis (RA) is probably the most common source of treatable disability in the Western world. There are several disease-modifying antirheumatic drugs (DMARDs), which have proven to be of therapeutic efficacy in RA, but the lack of a potent, reliable treatment for early RA is a major problem in modern medicine. An obvious line of approach in the quest for better antirheumatic drugs is

Popular Abstract in Swedish Faktor IX (FIX) är en molekyl som behövs för att blodet ska koagulera. Brist på FIX leder till blödarsjuka. För att öka den grundläggande förståelsen av hur FIX fungerar har vi gjort studier av en bit av FIX, som kallas för EGF1. EGF1 är en av två EGFmoduler som finns i FIX. De kallas EGFmoduler för att de liknar en annan molekyl, Epidermal Growth Factor. I denna avhandCoagulation factor IX (FIX) is a vitamin K-dependent serine protease zymogen that circulates in plasma. Defects in FIX cause the bleeding disorder hemophilia B. FIX contains a Gla module, two Epidermal Growth Factor (EGF) -like modules and a serine protease region. In this thesis, studies have been performed on the N-terminal EGF module, which binds one Ca2+. — The present results show that bindin

Popular Abstract in Swedish När födan efter en måltid kommer ned i tunntarmen, utsöndras ett protein som heter cholecystokinin, förkortat CCK, ifrån tarmslemhinnan till blodet. Ett ämne som frisätts på detta sätt till blodcirkulationen för att påverka celler i andra organ i kroppen kallas för hormon. CCK påverkar gallblåsan till att dra ihop sig och tömma sitt innehåll samtidigt som bukspottkörtelCholecystokinin (CCK) is known to exert secretory and trophic effects on the pancreas. Its release from the intestinal mucosa is regulated by pancresic proteases in the small intestine. However, knowledge about the type of responding exocrine cells and the time course of events during stimulation with CCK is lacking. Further, the role of CCK in the regulation of growth in other digestive organs is

The Lake Victoria basin (LVB) in East Africa can be considered a climate change hotspot because of its large rural population dependent on rain-fed farming. Drawing on extensive fieldwork (2007-2011) in rural communities along the shores of Lake Victoria in Kenya and Tanzania, I explore adaptive capacities to climate variability and change and discuss how they interrelate in situ. Using multiple m

Effects of the intrinsic electron spin-orbit interaction on transport and optical properties of III-V semiconductor quantum wells have been studied theoretically. It is shown that due to crystal anisotropy of this interaction, the weak localization magnetoresistance in a magnetic field parallel to interfaces is very sensitive to the epitaxy growth direction and also to the orientation of the magn

Popular Abstract in Swedish De senetruskiska votivhuvudena i terrakotta (bränd lera) från Tessennano på Medelhavsmuseet i Stockholm hittades 1956 i anslutning till en lantlig helgedom, ungefär tio mil norr om Rom, Italien. Att de är votivgåvor innebär att de skänktes av tillbedjare som representationer av dem själva inför gudomen eller gudomarna. Avhandlingen diskuterar emellertid inte de religiösThe Late etruscan terracotta votive heads from Tessennano were found near a rural sanctuary about a hundred km to the North of Rome in 1956. Whereas the facial fronts are serially produced with moulds, the backs are handmade. By using not only the moulded and the handmade features but the raw material (clay and temper) as well, it has been possible to make suggestions as to how, when and where the

Objective. To investigate the impact on ICD coding behaviour of a new case-mix reimbursement system based on coded patient diagnoses. The main hypothesis was that after the introduction of the new system the coding of chronic diseases like hypertension and cancer would increase and the variance in propensity for coding would decrease on both physician and health care centre (HCC) levels. Design. C

Life-threatening intracardiac and great vessels thrombi are rare in neonates. Recombinant tissue plasminogen activator (rTPA) is used in adults to stimulate fibrinolysis and facilitate thrombus resolution. Its use in neonates, along with heparin, remains controversial because of potential risk of serious bleeding. We aim to present our experience with the use of thrombolytic agents in seven neonat

The overall objective of this study is to examine how the institutional context of food safety affects and is affected by concerns for legitimacy and reputation. The paper employs a neo-institutional approach to analyzing the institutional field of food safety in a case study of a multinational food service provider where a tension between conflicting institutional logics implied a reputational ch

We have post-compressed 25 fs (Fourier limit) amplified pulses in an argon-filled hollow-core fiber. The output pulses were compressed using a pair of wedges and chirped mirrors down to 4.5 fs (Fourier limit of 4.1 fs), which corresponds to less than two optical cycles. We then performed the characterization of the pulses by combining the d-scan and the STARFISH techniques. The temporal (and spect

Objective. To investigate gender differences in the association between self-rated health (SRH) and impaired glucose tolerance (IGT) in subjects unaware of their glucose tolerance. Design. A cross-sectional population-based study. Setting. The two municipalities of Vara and Skovde in south-western Sweden. Subjects. A total of 2502 participants (1301 women and 1201 men), aged 30-75, were randomly s