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PURPOSE OF REVIEW: The purpose of this review is to provide a comprehensive evaluation of the most important type 2 diabetes gene to date, transcription factor 7 like-2. RECENT FINDINGS: An important step to find genetic causes of type 2 diabetes in 2006 was the identification of the fact that variants in the gene encoding transcription factor 7 like-2 reproducibly increase susceptibility to type
The np P Rydberg sequence of neutral Ytterbium is strongly perturbed. These perturbations were monitored by measuring the g(J) factors and lifetimes of 19 states, including both singlets and triplets as well as states from the perturbing configurations. A pulsed laser setup was used. The g(J) factors were obtained from a Zeeman quantum-beat experiment and the lifetimes by direct observation of the
The classical connectionist models are not well suited to working with data varying over time. According to this, temporal connectionist models have emerged and constitute a continuously growing research field. In this paper we present a novel supervised recurrent neural network architecture (SARASOM) based on the Associative Self-Organizing Map (A-SOM). The A-SOM is a variant of the Self-Organizi
Manganese (Mn) is an essential nutrient in humans, but excessive exposure to Mn may cause neurotoxicity. Despite homeostatic regulation, Mn concentrations in blood vary considerably among individuals. We evaluated if common single-nucleotide polymorphisms (SNPs) in SLC30A10, which likely encodes a Mn transporter, influence blood Mn concentrations and neurological function. We measured blood Mn con
Abstract in German Sogenannte sexuelle Minderheiten haben in Kanada grundlegende Veränderungen ihres rechtlichen und gesellschaftlichen Status erarbeitet. Zumindest bis in die 1960er Jahre galten schwule Männer auf Grund ihrer ‘Tendenzen’ als Gefahr für die nationale Sicherheit und als leichte Beute für (kommunistische) Erpressung. Gegenwärtig ermöglicht die kanadische Gesetzgebung die Ehe für gle
A real-time map must not contain too much information. Therefore, we need measures of map information that could guideline the selection of data layers and the real-time generalisation process. In this paper we evaluate measures of amount of information and distribution of information. The evaluation is performed by (1) defining measures, (2) implementing the measures, (3) computing the measures f
Ninety-eight patients, 56 suffering according to DSM-IV of unipolar depression and 42 of somatoform disorders, were compared on the Beck Depression Inventory (BDI) total scale, the subscale of Somatic complaints and the Cognitive-affective subscale. A factor analysis performed on the total group revealed five factors used to determine new subscales: Depressed mood, Somatic manifestations, Loss of
Cross-country regressions suggest that protectionism supported industrialization. I leverage novel and highly granular data covering Swedish manufacturing firms to estimate the impact of Sweden’s shift toward protectionism after 1891 on establishment-level development. Using mainly two-way fixed effects regressions, I show that tariff increases had a heterogeneous impact across establishments: ini
Using newly digitised colonial medical time-series data, this study makes a first attempt to provide an overview of the development of Western healthcare in Northern Rhodesia. The data is used to elaborate on the extent of the Christian missionary medical outreach to the African populace and the involvement of the African medical workers in establishing and expanding the Western healthcare system
This book is designed to help practitioners understand the growing potential for the use of Building Information Modelling (BIM) to improve Occupational Safety and Health (OSH) outcomes in the Architecture, Engineering, Construction, and Operations sector. Through a series of cutting-edge practical cases, an international team of researchers and practitioners examine the benefits, barriers, and ch
Aims Aortic valve calcification (AVC) is an underlying pathophysiological mechanism for aortic stenosis that is common in the elderly, but less is known in younger individuals. The aim was to study the prevalence and associated characteristics of AVC in a middle-aged general population. Methods and results Data were obtained from the Swedish CArdioPulmonary bioImage Study (SCAPIS) comprising 30 15
The aim of this paper is to explore how Edmund Husserl's phenomenological account of empathy, as well as Emmanuel Levinas' critical reception of the same, could contribute with clarity to the debate over the relevance of empathy to social work ethics. I suggest that more attention should be given to the pre-reflective character of empathy, according to Husserl's account. This resonates with Levina
Swedish Sign Language [svenskt teckenspråk, STS] has often been described as being the first officially recognised sign language in the world, passed into law in 1981. This was a parliamentary decision that later led to the provision of bimodal-bilingual education and the keeping of a separate school system for deaf students. However, today, STS is not granted the same rights as the five declared
