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Two oligonucleotide primers were used for selective enzymatic amplification of a DNA segment encoding a major portion of the first constant region domain (CH1) of the human IgG1 heavy chain. The selective amplification was confirmed by use of subclass-specific oligonucleotide probes. Two 15-mer oligonucleotides, hybridizing with the alleles for the allotypes G1m(f) and (z), respectively, could the
The aggravating effect of hyperglycemia on ischemic brain injury can be mimicked in a model of in vitro ischemia (IVI) using murine hippocampal slice cultures. Using this model, we found that the damage in the CA1 region following IVI in the absence or presence of 40 mM glucose (hyperglycemia) is highly temperature dependent. Decreasing the temperature from 35 to 31 degrees C during IVI prevented
The current study aims to clarify the relationship between fear of crime and risk perception, age, gender, direct victimization and indirect victimization. The study also aims to explore how the relationship between victim and perpetrator affect the victim’s fear of crime and risk perception. A survey concerning fear of crime, risk perception, known/unknown perpetrator and earlier victimization wa
In the European Union, innovation policies have called for boosting the innovative capacity of youth through education. Despite all efforts made towards this end, however, European economies still find youth innovation to be scarce. This scarcity exists in the region of Skåne too, and is evident in the increasing youth unemployment rates. The objective of this thesis is to shed a new light on this
Patients with diabetes mellitus (DM) have high platelet reactivity and are at increased risk of ischaemic events and bleeding post-acute coronary syndromes (ACS). In the PLATelet inhibition and patient Outcomes (PLATO) trial, ticagrelor reduced the primary composite endpoint of cardiovascular death, myocardial infarction, or stroke, but with similar rates of major bleeding compared with clopidogre
Nonsense mutations in FGF16 have recently been linked to X-linked recessive hand malformations with fusion between the fourth and the fifth metacarpals and hypoplasia of the fifth digit (MF4; MIM#309630). The purpose of this study was to perform careful clinical phenotyping and to define molecular mechanisms behind X-linked recessive MF4 in three unrelated families. We performed whole-exome sequen
The reactions between chalcocite, synthetic copper(I) sulfide, acanthite and synthetic silver(I) sulfide, and aqueous and acetone solutions of potassium ethylxanthate have been studied. Qualitative analysis of the ethylxanthate species present on the surfaces of the sulfide minerals and the synthetic metal sulfides has been made by means of diffuse reflectance infrared Fourier transform (DRIFT) sp
BACKGROUND--Formoterol and salmeterol are new long acting beta 2 adrenoceptor agonists. The maximum relaxant effect, potency and functional antagonism against carbachol induced contraction for salmeterol, formoterol and salbutamol have been compared in the guinea pig isolated trachea. In addition, the possibility of inducing a non-beta adrenoceptor mediated relaxation by salmeterol was studied. ME
Intermittent fasting may impart metabolic benefits independent of energy balance by initiating fasting-mediated mechanisms. This randomized controlled trial examined 24-hour fasting with 150% energy intake on alternate days for 3 weeks in lean, healthy individuals (0:150; n = 12). Control groups involved a matched degree of energy restriction applied continuously without fasting (75% energy intake
Gadolinium-148 is one of the radionuclides of most concern that will be produced in the tungsten target of the European Spallation Source (ESS), as a by-product of the spallation reaction used by the facility to produce neutrons. Since 148Gd a pure alpha emitter, it is both very radiotoxic and difficult to measure. With its half-life of 75 years, it will remain in the environment for a long time i
The declining trend in cardiovascular mortality rates seen since the mid-1970s in Western countries have been more pronounced for people in higher socioeconomic status (SES) groups. The fact that established risk factors, are limited in explaining the socioeconomic differences in cardiovascular disease (CVD) has opened new fields of research. One such field is the role of SES in the preclinical (a
Title: Using scenarios to balance future requirements and capability development Author: Erik Jacobsson Division: Production Management Supervisors: Bertil Nilsson at the Technical Faculty of Lund University, Innovation Advisor at the case company Keywords: Scenarios, Corporate development, Energy Sector, Capabilities, Technology Background: The speed of change in the world is ever increasing
The purpose of the research thesis is to examine which steps are evident in the development of innovations in family businesses, and to determine which steps of the innovation process are affected by traditions and knowledge. An abductive method was used for the thesis, together with a qualitative research consisting of interviews with respondents from the two case study companies Engelholmsglass
Förevarande uppsats syftar till att utreda vilka drivkrafter som föregick och motiverade rättsutvecklingen inom prostitutionslagstiftningen mellan åren 1850 och 1999. Därtill redogör uppsatsen för hur statsmaktens inställning gentemot prostitution och prostituerade kvinnor tog sig uttryck i den legisla-tiva utvecklingsprocessen. Arbetet har genomförts med hjälp av en rättshisto-risk metod för att This paper aims to investigate the driving forces that preceded and motivated the developments of the law in legislation concerning prostitution between the years of 1850 and 1999 in Sweden. Further more, the paper describes how the state's attitude towards prostitution and prostituted women was expressed in the legislative development process. The work has been undertaken using a legal-histor
This thesis is a study of conflicting perceptions provoked by Enhedslisten’s, Danish political party, attempt to practice socialist feminism organizationally. I locate three sites of conflicts; socialism(s) and organization of power, feminism(s), and queer culture and approach them from a theoretical framework of primarily Foucault, Panebianco, Halley, Young, Fraser, and Butler. I conduct four eth
It is difficult to prepare for events with large-scale consequences and low probability. Simulation exercises (SimEx) provide the opportunity to improve preparedness through strengthening capabilities before an actual emergency. Conducting a SimEx could be very expensive and therefore the SimEx should be thoroughly evaluated. Action plans (AP) determine the relevant recommendations to be implement
The increasing integration of Bitcoin with traditional stock markets makes understanding its impact on stock market volatility crucial. This paper constructs a GARCH-MIDAS model using data from the Shanghai Composite Index, the S&P 500 Index, and Bitcoin to investigate Bitcoin's influence under different regulatory environments. The results show that Bitcoin has a significant negative rela
Due to the environmental impact of food waste and its implications on the economic performance of restaurants, the importance of reducing food waste has taken a central role in the management of restaurants. This paper examines the difficulties which arise in the restaurant industry in their efforts to reduce food waste. In addition the paper aims to answer the following questions: Is food waste p
