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3-DOF Gantry Tau is a type of parallel robot, consisting of six struts configured in three clusters, which provides three translational DOFs. It has increasing industrial use in applications where large workspace and high stiffness are required. In fact, the concept of dynamic isotropy, where all the natural frequencies of a system are equal, can be employed in order to effectively optimize the ge

1. The amino acid l-3,4-dihydroxyphenylalanine (l-DOPA) was extracted from tentacles of the sea anemone Metridium senile and from brains of the crayfish Pacifastacus leniuscuius.2. The identity of l-DOPA was ascertained by gas chromatography-mass spectrometry as the heptafluorobutyryl iso-butyl ester derivative. Dopa is identified with GC-MS for the first time and the derivatization is a novel mod

When a biomaterial is inserted into the body, proteins rapidly adsorb onto its surface, creating a conditioning protein film that functions as a link between the implant and adhering cells. Depending on the nano-roughness of the surface, proteins will adsorb in different amounts, with different conformations and orientations, possibly affecting the subsequent attachment of cells to the surface. Th

Intrinsically disordered proteins (IDPs) adopt heterogeneous conformational ensembles in solution. The properties of the conformational ensemble are dependent upon the solution conditions, including the presence of ions, temperature, and crowding, and often directly impact biological function. Many in vitro investigations focus on the properties of IDPs under dilute conditions, rather than the cro

In this article, it is shown that by exposing commonly used lipids for biomembrane mimicking studies, to a solution containing the histidine-rich intrinsically disordered protein histatin 5, a protein cushion spontaneously forms underneath the bilayer. The underlying mechanism is attributed to have an electrostatic origin, and it is hypothesized that the observed behavior is due to proton charge f

Mobile communications have been undergoing a generational change every ten years or so. However, the time difference between the so-called "G's" is also decreasing. While fifth-generation (5G) systems are becoming a commercial reality, there is already significant interest in systems beyond 5G, which we refer to as the sixth-generation (6G) of wireless systems. In contrast to the already published

Supervising a student can be compared to teaching someone to drive a car. The student is in the driver’s seat while the supervisor provides structure and guidance, and can intervene in risky and unsafe situations. It is a learning process in which the student gradually gains experience and sufficient skill to obtain a driving license, and to drive without an instructor. Similarly, a student attend

Background. Test automation is a widely used technique to increase the efficiency of software testing. However, executing more test cases increases the effort required to analyze test results. At Qlik, automated tests run nightly for up to 20 development branches, each containing thousands of test cases, resulting in information overload. Aim. We therefore develop a tool that supports the analysis

Students completing a Swedish Master’s degree in engineering should have knowledge and skills to independently solve engineering issues. This autonomy should be developed and demonstrated within the M.Sc. project course. But, how can supervisors encourage independence? We have explored this in a case study through semi-structured interviews with students, supervisors and examiners of two M.Sc. pro

Five peptides previously suggested to possess polyproline II (PPII) structure have here been investigated by using atomistic molecular dynamics simulations to compare how well four different force fields known for simulating intrinsically disordered proteins relatively well (Amber ff99SB-disp, Amber ff99SB-ILDN, CHARM36IDPSFF, and CHARMM36m) can capture this secondary structure element. The result

Intrinsically disordered proteins are involved in many biological processes such as signaling, regulation, and recognition. A common strategy to regulate their function is through phosphorylation, as it can induce changes in conformation, dynamics, and interactions with binding partners. Although phosphorylated intrinsically disordered proteins have received increased attention in recent years, a

Using light scattering (LS), small-angle X-ray scattering (SAXS), and coarse-grained Monte Carlo (MC) simulations, we studied the self-interactions of two monoclonal antibodies (mAbs), PPI03 and PPI13. With LS measurements, we obtained the osmotic second virial coefficient, B22, and the molecular weight, Mw, of the two mAbs, while with SAXS measurements, we studied the mAbs' self-interaction behav

The osmotic pressure of dilute electrolyte solutions containing charged macro-ions as well as counterions can be computed directly from the particle distribution via the well-known cell model. Originally derived within the Poisson-Boltzmann mean-field approximation, the cell model considers a single macro-ion centered into a cell, together with counterions needed to neutralize the total cell charg

Massive multiple-input multiple-out (MIMO) technology is vital in millimeter-wave (mmWave) bands to obtain large array gains. However, there are practical challenges, such as high hardware cost and power consumption in such systems. A promising solution to these problems is to adopt a hybrid beamforming architecture. This architecture has a much lower number of transceiver (TRx) chains than the to

Free-energy calculations are crucial for investigating biomolecular interactions. However, in theoretical studies, the neglect of electronic polarization can reduce predictive capabilities, specifically for free-energy calculations. To effectively mimick polarization, we explore a Charge Switching (CS) model, aiming to narrow the gap between computational and experimental results. The model requir