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Introduction and hypothesis: The objective was to compare the effect of antibiotics versus no antibiotics prophylaxis per-operatively on the frequency of urinary tract infection (UTI) following mid-urethral sling application to treat stress or mixed urinary incontinence. Methods: This study was designed as a multicenter prospective randomized trial. Women were included from eight centers in three
Standardization, auditing, and performance measurement increasingly characterize the governance of professional organizations. In hospital services, this is expressed in a multiplication of quality as- surance programmes, which may be characterized as technologies of quality control. Organizational research shows that the impact of such technologies is profound and often problematic. Even if roote
Twenty years have passed since first light for the Sloan Digital Sky Survey (SDSS). Here, we release data taken by the fourth phase of SDSS (SDSS-IV) across its first three years of operation (2014 July-2017 July). This is the third data release for SDSS-IV, and the 15th from SDSS (Data Release Fifteen; DR15). New data come from MaNGA - we release 4824 data cubes, as well as the first stellar spec
Two new potential ligands of the Drosophila PS2 integrins have been characterized by functional interaction in cell culture. These potential ligands are a new Drosophila laminin α2 chain encoded by the wing blister locus and Ten-m, an extracellular protein known to be involved in embryonic pattern formation. As with previously identified PS2 ligands, both contain RGD sequences, and RGD-containing
Protein G is a streptococcal cell wall protein with separate and repetitively arranged binding domains for immunoglobulin G (IgG) and human serum albumin (HSA). In this work, the binding of protein G to HSA was studied. The results suggest that a single binding site is present on HSA: the apparent size of the HSA-protein G complex (230 kDa) corresponded to two or three HSA molecules bound to one p
LUC‐CNDO computation scheme and its valence theory applications are discussed. Electronic structure calculations of well‐known semiconductors Cu2O are reviewed. The parameters of CNDO scheme for copper–oxygen compounds are calibrated using the results of Cu2O band theory calculations and experimental data.
Transient global ischaemia induces the expression of immediate early genes. Using in situ hybridization, the expression of c‐fos, fosB, fra‐1, fra‐2, c‐jun and junB was studied after 15 min of normothermic and hypothermia (33°C) transient forebrain ischaemia in the rat, induced by common carotid occlusion combined with systemic hypotension. Two phases of induction of the immediate early genes were
A search for singly produced vector-like quarks Q, where Q can be either a T quark with charge +2/3 or a Y quark with charge −4/3, is performed in proton–proton collision data at a centre-of-mass energy of 13 TeV corresponding to an integrated luminosity of 36.1 fb−1, recorded with the ATLAS detector at the LHC in 2015 and 2016. The analysis targets Q → Wb decays where the W boson decays leptonica
The influence of eight different N-terminal protecting groups (For, Ac, Boc, Fmoc, Mal, Pheac, Aloc and Z) on the α-chymotrypsin-catalyzed synthesis of the dipeptide derivative X-Phe-Leu-NH2 in organic media was studied. Groups such as Ac, For, Boc, Z, Mal, Pheac and Alloc always rendered good peptide yields (92% to 99%) either in acetonitrile or in ethyl acetate. Good correlations were found betw
The presentation will describe the results of a randomized controlled trial of cognitive therapy for childhood GAD, including analyses of mediation of outcome by changes in intolerance of uncertainty.
Asymptomatic bacteriuria (ABU) is highly prevalent among elderly patients. It can be difficult to distinguish ABU from symptomatic urinary tract infection (UTI) in this population, which leads to unnecessary antibiotic treatment. Urinary heparin-binding protein (U-HBP) and urinary interleukin-6 (U-IL-6) have previously been studied as diagnostic markers for UTI. In this study, biomarkers were meas
Unilateral lesions of nigrostriatal dopamine ( DA) pathways with 6-hydroxydopamine (6-OHDA) can be used to obtain a model of Parkinson's disease in the mouse. In the present study we examine two types of unilateral 6-OHDA lesions in the mouse for their ability to induce stable motor deficits and supersensitive molecular and behavioural response to L-DOPA.
The transcription factor STAT3 is a potential target for the treatment of castration-resistant prostate cancer. Galiellalactone (1), a direct inhibitor of STAT3, prevents the transcription of STAT3 regulated genes. In this study we characterized 6 (GPA512, Johansson, M.; Sterner, O. Patent WO 2015/132396 A1, 2015), a prodrug of 1. In vitro studies showed that 6 is rapidly converted to 1 in plasma
One of the few and most complete records of the MDICE (Middle Darriwilian Isotope Carbon Excursion) is herein documented from Baltoscandia. Based on a core section penetrating the condensed Lower–Middle Ordovician succession (~46 m) on the island of Öland, southeastern Sweden, we provide an integrated scheme for carbon isotope chemostratigraphy (313 samples) and conodont biostratigraphy (29 sample
Nation brands are intended to act as vehicles for economic development. However, the role of the nation brands of developed countries in shaping the economic development of developing countries has not been explored to the same degree. Using the example of Britain’s 2010 National Security Strategy, this article argues that the two-decade long decline in conditional aid has been superseded by effor
We investigated the skin sensitization hazard of glyphosate, the surfactant polyethylated tallow amine (POEA) and two commercial glyphosate-containing formulations using different omics-technologies based on a human dendritic cell (DC)-like cell line. First, the GARD™skin assay, investigating changes in the expression of 200 transcripts upon cell exposure to xenobiotics, was used for skin sensitiz
