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The skin provides an attractive alternative to the conventional drug administration routes. Still, it comes with challenges as the upper layer of the skin, the stratum corneum (SC), provides an efficient barrier against permeation of most compounds. One way to overcome the skin barrier is to apply chemical permeation enhancers, which can modify the SC structure. In this paper, we investigated the
Background: A novel data-driven classification of type 2 diabetes has been proposed to personalise anti-diabetic treatment according to phenotype. One subgroup, severe insulin-resistant diabetes (SIRD), is characterised by mild hyperglycaemia but marked hyperinsulinaemia, and presents an increased risk of diabetic nephropathy. We hypothesised that patients with SIRD could particularly benefit from
This research report was prepared in the framework of the EU-funded project “Central Asian Law: Legal Cultures and Business Environments in Central Asia” (project number 870647 H2020 MSCA-RISE 2019-2023), which runs from 01/03/2020 through 28/02/2024. The project is coordinated by Lund University, and the project consortium includes European universities (University of Zurich, Charles University P
Supply chain visibility is a concept that is gaining increasing attention. Increasing levels of visibility in the supply chain is considered beneficial in many respects. A systematic literature review identified 47 empirical research papers from international scientific journals. Two main findings emerged from the content analysis. First, the perspectives provided in the extant literature can be g
This commentary elaborates on different methodological aspects complicating the interpretation of epidemiological data related to the current COVID-19 pandemic, thus preventing reliable within and across-country estimates. Firstly, an inaccuracy of epidemiological data maybe arguably be attributed to passive surveillance, a relatively long incubation period during which infected individuals can st
This study aimed to investigate self-reported physical activity levels, perceived body appearance, and body functioning in relation to perceived wellbeing among adolescents. A cross-sectional survey was performed in four upper secondary schools in one municipality in southern Sweden. Data were obtained from questionnaires completed by 1,491 adolescents (55.4% females; median age 16; range 15–17 ye
The book identifies the key analytical issues that need to be considered in determining whether a State is responsible under the ECHR for omissions. The focal question is whether and how omissions by the State can be conceptualised into failures to fulfil positive obligations. In addition to this technical analytical question, the book also reflects upon what is at stake for the political communit
This paper analyses the inherent competence conflict between the economic and the monetary policies under EU law. The particular policy areas have come under scrutiny with regards to the financial rescue packages issued in the course of the financial crisis (PSPP) as well as the Covid-19 pandemic (PEPP). Both crises have exposed some of the Union’s core morbidities: a lack of competence at EU leve
The structures of two fungal norsesquiterpenes containing a diepoxide functionality, isolated from cultures of the basidiomycete Resupinatus leightonii, were elucidated by a combination of X-ray analysis, NMR spectroscopy and molecular mechanics calculations.
First-generation migrants tend to have better health than those of native ancestry, while second-generation migrants often are affected by negative health assimilation. Less is known about immigrants arriving before their teens, the 1.5 generation, or those with one native and one immigrant parent, the 2.5 generation. We apply logistic regression models to study physical and mental health outcomes
This paper contributes to the literature on long-term changes in intergenerational persistence of equality of opportunity. Social origin is measured comprehensively both as social class background, and estate-based surname status origin – both from mothers and fathers. The paper aims to link an expanding literature on surname mobility to the conventional field of intergenerational mobility researc
Hizbullah, or the Islamic Resistance in Lebanon, is considered a key actor in Lebanon and theMiddle East. Its importance is often attributed to its commitment to an armed struggle against Israel, its ties with the Islamic Republic in Iran and, more recently, to its military engagementin regional conflicts. Much less attention is given to the relationship between Hizbullah and its constituents in L
As global migration alters the demography of Swedish cities in the postwelfare era, socio-spatial polarisation and discrimination present acute challenges. In recent decades, Malmö has transformed from an industrial into a postindustrial, service economy-oriented city. The neoliberal urban planning and regeneration policies guiding such processes carry detrimental social and economic effects for u
Synthesis of diketopiperazines has been of long-standing interest in both natural product synthesis and medicinal chemistry. Here, we present an operationally convenient and efficient approach to the fused indoline-diketopiperazine tricyclic core of glionitrin A/B and related structures using a Pd-catalyzed C-H activation reaction to form the indoline five-membered ring. Exploratory work aimed at
