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In order to stay competitive and meet the changing needs of the market, construction firms must develop efficient means of gathering and using knowledge of end-users requirements. This study uses two case studies, to explore the knowledge creation of end-users requirements in project driven firms. The focus of the study is the interface between firm and project. The interface is analyzed from both

Popular Abstract in Swedish SVENSK SAMMANFATTNING Den kliniska effekten av läkemedel som administreras till näsa eller lunga beror på läkemedlets egenskaper och på dess lokala deposition. Depositionsstudier är därför värdefulla för att kunna karakterisera olika beredningar. Depositionen påverkas av partiklarnas storlek och hastighet, genom att stora partiklar med hög hastighet ger upphov till en hThe local deposition, pharmacokinetics, and systemic activity of inhaled and intranasal glucocorticosteroids in different formulations and devices(ICSs) has been investigated. After nasal administration of the ICS budesonide (Bud), the systemic availability (F) was found to be significantly higher from an aqueous pump spray and from the powder inhaler Turbuhaler, than from a pressurized metered do

Popular Abstract in Undetermined Vårt immunförsvar består av molekyler, celler, och barriärer som har till uppgift att hålla oss friska genom att avlägsna eller stänga ute virus och skadliga mikroorganismer. På alla kärnförsedda celler i vår kropp sitter en stor mängd MHC klass I-molekyler, strukturer som kan liknas vid korgar. I varje korg ligger en peptid som är ett fragment av något som finns iHuman leukocyte antigen class I (HLA-I) molecules are present on all nucleated cells and present the cell content to cytotoxic T lymphocytes in the form of peptides. Maturation of HLA-I occurs in the endoplasmic reticulum and results in stable peptide-HLA-I complexes, in the presence of proper quality control. For proper peptide binding most HLA-I molecules interact with the peptide-loading comple

Mitochondrial permeability transition (MPT) is induced in isolated brain mitochondria by calcium and oxidants and is inhibited by adenine nucleotides. When induced, MPT is associated with equilibration of solutes of <1500 Da across the inner mitochondrial membrane. A persistent induction of MPT depolarizes the inner membrane and causes cessation of ATP synthesis, swelling of the matrix, and bursti

This doctoral thesis has its theoretical origin in the notion that the information flow between management teams, financial analysts and investors is especially exposed to information asymmetry when knowledge-intense companies are concerned. Information asymmetry may aggravate agency problems and risk causing an impairment of the efficient allocation of capital on the stock market. Therefore, the

This article analyses the doctrine of free will (autexousion) in the confessions of St. Peter Mogila and Dositheos II Notaras of Jerusalem. Free will is a central concept in Eastern Christian anthropology and these two monuments of theology represent how the understanding of the concept of free will developed in Eastern Orthodox theology in the context of the confrontation with Western theologies

Chemokines constitute a class of small inflammatory proteins that control the chemotaxis of leukocytes. They are also present in the central nervous system (CNS) and contribute to diverse physiological functions, such as the regulation of cell migration, axonal growth and neuronal survival. It is to date not known whether chemokines in the CNS are affected in psychiatric disorders. In this study,

The aim of the study was to investigate workplace incivility as a social process, examining its components and relationships to both instigated incivility and negative outcomes in the form of well-being, job satisfaction, turnover intentions, and sleeping problems. The different components of incivility that were examined were experienced and witnessed incivility from coworkers as well as supervis

Brattforsheden is a large glacifluvial deposit in southwestern Sweden and associated with it is one of Sweden's largest inland dune fields. Although the relative ages of the Brattforsheden deposits are well known, absolute ages from the area are few. In this study we have used optically stimulated luminescence (OSL), surface exposure (Be-10) and radiocarbon (C-14) dating to provide an absolute chr

The aim of this study is to identify loci associated with circulating levels of Interleukin 8 (IL8). We investigated the associations of 121,445 single nucleotide polymorphisms (SNPs) from the Illumina 200K CardioMetabochip with IL8 levels in 1077 controls from the Stockholm Heart Epidemiology Program (SHEEP) study, using linear regression under an additive model of inheritance. Five SNPs (rs12075

This study explores the worldwide spatial evolution of scientific knowledge production in biotechnology in the period 1986-2008. We employ new methodology that identifies new key topics in biotech on the basis of frequent use of title worlds in major biotech journals as an indication of new cognitive developments within this scientific field. Our analyses show that biotech is subject to a path- an

Many manufacturing firms are expanding their global footprint to explore new opportunities for efficient and effective production. The strategic perspective on international manufacturing networks involves both the network level and the plant level. A key aspect is the relationship between the network and the role of plants. In this research, we investigate the relationship between the network and

Psychoanalysis opens a variety of windows into understanding contemporary consumption and consumerism. The psychoanalytic theory of defence and the unconscious enables us to understand why commodities, from fast cars to luxury chocolate, so readily stand in to offer substitute gratification for deeper repressed desires and why the meaning of such commodities is liable to become mobile and unstable

Recently, a hexanucleotide (GGGGCC) repeat expansion in the first intron of C9ORF72 was reported as the cause of chromosome 9p21-linked frontotemporal dementia-amyotrophic lateral sclerosis (FTD-ALS). We here report the prevalence of the expansion in a hospital-based cohort and associated clinical features indicating a wider clinical spectrum of C9ORF72 disease than previously described. We studie