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5-HT(1) receptor agonists have been shown to reduce abnormal involuntary movements (AIMs) in the rat and monkey models of l-DOPA-induced dyskinesia. Different mechanisms have been proposed to underlie this effect. Activation of pre-synaptic 5-HT(1) receptors has been suggested to inhibit dysregulated release of dopamine from the serotonin terminals, and thus, abnormal activation of striatal dopami
Hyperglycemia and hypercapnia aggravate intra-ischemic acidosis and subsequent brain damage. However, hyperglycemia causes more extensive post-ischemic damage than hypercapnia, particularly in the cingulate cortex. We investigated the changes in the subcellular distribution of protein kinase Cgamma(PKCgamma) and the Ca2+/calmodulin-dependent protein kinase II (CaMKII), as well as changes in protei
The aim of the present study was to examine autonomic function in response to negatively and positively valenced pictures under different levels of conscious recognition. Heart period variability (HPV) and heart rate (HR) reactivity were studied in 53 males and females who were being shown pictures of angry and happy faces. The pictures, which were backwardly masked, were presented once every 30 s
Several lines of evidence suggest that a calcitonin-gene related peptide (CGRP) receptor antagonist may serve as a novel abortive migraine treatment. Here we present data on a human cell line and isolated human vessels for such an antagonist, BIBN4096BS. On SK-N-MC membranes, radiolabelled CGRP was displaced by both CGRP-(8-37) and BIBN4096BS, yielding pK(i) values of 8.5 and 11.4, respectively. F
Yeast to be used in simultaneous saccharification and fermentation (SSF) of lignocelluloses materials has to be prepared in a separate cultivation step. The effects of the cultivation procedure on the performance of SSF of steam pretreated softwood were studied in the current work. The yeast used in the SSF was either directly commercially available Baker's yeast (as packaged yeast) or the same st
The glutathione S-transferase P1 genotype (GSTP1) is involved in the inactivation of cigarette smoke carcinogens, and sequence variation in the gene may alter bladder cancer susceptibility. To examine the association between GSTP1lle 105Val and bladder cancer, the authors undertook a meta- and pooled analysis. Summary crude and adjusted odds ratios and corresponding 95% confidence intervals were p
The relationship between monthly sea-surface temperature (SST) in the tropical Pacific and the Indian Ocean and monthly precipitation over the Vietnamese central highlands (VCH) has been investigated by means of singular value decomposition. The seasonal variation of SST plays a critical role in the onset of the monsoon season and convective rain band movement in the inter-tropical convergence zon
OBJECTIVES: This study compares questionnaire-assessed exposure data on work postures and movements with direct technical measurements. METHODS: Inclinometers and goniometers were used to make full workday measurements of 41 office workers and 41 cleaners, stratified for such factors as musculoskeletal complaints. The subjects answered a questionnaire on work postures of the head, back, and upper
Background: Much effort has been made to study first-ever stroke patients. However, recurrent stroke has not been investigated as extensively. It is unclear which risk factors dominate, and whether adequate secondary prevention has been provided to patients who suffer from recurrent stroke. Also, the different types of recurrent stroke need further evaluation. Methods: The study included patients
In this article we compare the acquisition of determiners in bilingual children acquiring Italian simultaneously with German or Swedish. We are concerned with cross-linguistic differences in the rate of acquisition and we discuss in particular the Nominal Mapping Parameter, a model according to which the syntax-semantics interface is crucial in acquisition and which predicts similar developmental
In the Silurian, Baltica and Laurentia collided to form the Caledonian orogenic belt. During this process, nappes derived from the pre-collisional Baltic margin, from outboard terranes of Baltica, and from exotic terranes of probable Laurentian origin, respectively, were thrust upon the indenting Baltica. The Middle Allochthon is a tectonostratigraphic level inferred to represent the rifted Neopro
We have studied the pH effect on the S0 and S2 multiline electron paramagnetic resonance (EPR) signals from the water-oxidizing complex of photosystem II. Around pH 6, the maximum signal intensities were detected. On both the acidic and alkaline sides of pH 6, the intensities of the EPR signals decreased. Two pKs were determined for the S0 multiline signal; pK1 = 4.2 ± 0.2 and pK2 = 8.0 ± 0.1, and
Allozyme variation in 83 European populations of the Melica ciliata/transsilvanica species complex has been investigated. In spite of a diploid chromosome number, most loci were duplicated and patterns of within-population variation were not explainable unless apomixis or uncommon patterns of chromosomal segregation were assumed. Allelic richness and genetic diversity were very high but most of th
Cystihalysites sp. from the Ludfordian Eke Formation on Gotland, Sweden, is the youngest halysitid coral found in Baltoscandia. Halysitids had earlier been considered as absent at this level and were thought to have disappeared in the Gorstian-lower Ludfordian Hemse Group. The new material indicates that at least one species survived the early parts of the Lau extinction event.
Background: The purpose of this study was to evaluate the incidence and the long-term results of closed uncomplicated Mason type-II and III fractures in a defined population of adults. Methods: Seventy women and thirty men who were a mean of forty-seven years old when they sustained a fracture of the radial head or neck (a Mason type-II fracture in seventy-six patients and a Mason type-III fractu
Previous studies suggest that obesity is related to increased risk of renal cell carcinoma (RCC); however, only a few studies report on measures of central vs. peripheral adiposity. We examined the association between anthropometric measures, including waist and hip circumference and RCC risk among 348,550 men and women free of cancer at baseline from 8 countries of the European Prospective Invest
Samhällsvetenskapliga fakultetens samverkan med det omgivande samhället Kartläggning och analys CHARLOTTE SIMONSSON & CHRISTOFFER HAHN SAMHÄLLSVETENSKAPLIGA FAKULTETEN | LUNDS UNIVERSITET 2 SAMVERKAN MED DET OMGIVANDE SAMHÄLLET Coverphoto by Petra Francke Layout and typesetting : Media-Tryck, Lund University Lund 2020 3SAMVERKAN MED DET OMGIVANDE SAMHÄLLET Innehåll Inledande om syfte och tillvägag
Brain Plasticity 3 (2017/2018) 195–203 DOI 10.3233/BPL-180066 IOS Press 195 Review Crosstalk between MicroRNAs and Autophagy in Adult Neurogenesis: Implications for Neurodegenerative Disorders Karolina Pircs1, Rebecca Petri1 and Johan Jakobsson∗ Department of Experimental Medical Science, Laboratory of Molecular Neurogenetics, Wallenberg Neuroscience Center and Lund Stem Cell Center, Lund Universi
There are inconsistent and limited data available to assess the relationship between fat intake and risk of epithelial ovarian cancer (EOC). We examined the consumption of total fat, fat sources and fat subtypes in relation to risk of EOC and its major histologic subtypes in the European Prospective Investigation into Cancer and Nutrition which includes incident invasive (n=1095) and borderline (n
