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The trigeminovascular system plays a central role in migraine, a condition in need of new treatments. The neuropeptide, calcitonin gene-related peptide (CGRP), is proposed as causative in migraine and is the subject of intensive drug discovery efforts. This study explores the expression and functionality of two CGRP receptor candidates in the sensory trigeminal system.

Breast cancer is the most common cancer among women worldwide with approximately 1.150.000 new cases each year and accounting for over 400.000 deaths per year. The main cause of death for women with breast cancer is secondary tumors. Downregulation of Wnt5a in primary ductal breast cancer has been correlated with poor outcome and higher tumor grade and found to be an independent predictor of rec

In a naturalistic newspaper reading study, two pairs of information graphics have been designed to study the effects of a) the spatial contiguity principle and b) the dual scripting principle by means of eye tracking measurements. Our data clearly show that different spatial layouts have a significant effect on readers’ eye movement behaviour. An integrated format with spatial contiguity between t

The complexity of Ca2+ cell signaling is dependent on a plethoria of Ca2+-binding proteins that respond to signals in different ranges of Ca2+ concentrations. Since the function of these proteins is directly coupled to their Ca2+-binding properties, there is a need for accurately determined equilibrium Ca2+-binding constants. In this work we outline the experimental techniques available to determi

Pollen analyses and AMS C-14 measurements were performed on lacustrine sediments and peat sequences from two former crater lakes (Preluca Tiganului, Steregoiu) situated in the Gutaiului Mountains in northwestern Romania, in order to reconstruct the vegetation development during the Lateglacial and Early Holocene. Before c. 14,700 cal. years BP (GS-2) open vegetation with shrubs (Salix, Juniperus),

We studied the effects of predatory crayfish (Pacifastacus leniusculus), the non-lethal effects of fish chemical cues (Oncorhynchus mykiss), and the combined effects of crayfish and fish chemical cues on the performance of tadpoles of two co-existing anuran species, Rana temporaria and Bufo bufo, in experimental pools. We also examined grazing effects on periphyton, the main food source for the ta

We studied the anti-inflammatory properties of probiotic strains and blueberry in a colitis model. The disease activity index (DAI) was significantly lower on days 9 and 10 in all groups compared to the colitis control. Myeloperoxidase (MPO) and bacterial translocation to the liver and to the mesenteric lymph nodes (MLN) decreased significantly in all groups compared to colitis control. Cecal Ente

This article proposes a bias-adjusted estimator for use in cointegrated panel regressions when the errors are cross-sectionally correlated through an unknown common factor structure. The asymptotic distribution of the new estimator is derived and is examined in small samples using Monte Carlo simulations. For the estimation of the number of factors, several information-based criteria are considere

The article describes qualitative variation in micro processes of learning, focusing the dynamic interplay between conceptions, expressions and meanings of expressions in students' learning in higher education. The intentional-expressive approach employed is an alternative approach to the function of language use in learning processes. In the empirical investigation, a dialogue model was used that

Paxillus involutus (basidiomycetes, Boletales) is a common ectomycorrhizal fungus in the Northern Hemisphere. The fungus displays significant variation in phenotypic characters related to morphology, physiology, and ecology. Previous studies have shown that P. involutus contains several intersterility groups and morphological species. In this study, we have used concordance of multiple gene geneal

We have studied the binding of Zn2+ to the hexa EF-hand protein, calbindin D(28k)-a strong Ca2+-binder involved in apoptosis regulation-which is highly expressed in brain tissue. By use of radioblots, isothermal titration calorimetry, and competition with a fluorescent Zn2+ chelator, we find that calbindin D(28k) binds Zn2+ to three rather strong sites with dissociation constants in the low microm

We measure the chirp rate of harmonics 13 to 23 in argon by cross correlation with a 12 femtosecond probe pulse. Under low ionization conditions, we directly measure the negative chirp due to the atomic dipole phase, and show that an additional chirp on the pump pulse is transferred to the qth harmonic as q times the fundamental chirp. Our results are in accord with simulations using the experimen

Inflammatory myofibroblastic tumor (IMT) is a neoplasm composed of myofibroblastic spindle cells and infiltrating inflammatory cells. Cytogenetic analyses have revealed that a subgroup of IMT, in particular among children and young adults, harbors clonal chromosomal rearrangements involving chromosome band 2p23. Further, molecular genetic studies have shown that these rearrangements target the ALK

As pan of the study "The Burden of Rheumatoid Arthritis (RA) and Patient Access to Treatment", this paper reviews the impact on access to RA drugs of the approval processes, pricing and funding decisions and times to market (access) in different countries. In addition, an overview of health technology assessments (HTA) and the economic literature related to RA treatments is provided. The time from

Carbon dating of basal peat deposits in Cumberland Bay and Stromness Bay and sediments from a lake in Stromness Bay, South Georgia indicates deglaciation at the very beginning of the Holocene before c. 9500 C-14 yr BP. This post-dates the deglaciation of one local lake which has been ice-free since at least 15 700 C-14 yr BP on account of its atypical geomorphological location. The latter indicate