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Recently, a hexanucleotide (GGGGCC) repeat expansion in the first intron of C9ORF72 was reported as the cause of chromosome 9p21-linked frontotemporal dementia-amyotrophic lateral sclerosis (FTD-ALS). We here report the prevalence of the expansion in a hospital-based cohort and associated clinical features indicating a wider clinical spectrum of C9ORF72 disease than previously described. We studie
The RISING setup at the GSI-FRS facility was used to investigate the isomer and beta decays in N~Z~50 Cd, Ag and Pd isotopes. A preliminary analysis of the data has revealed new results on the Tz=1, 94Pd, 96Ag and 98Cd isotopes. In 94Pd a new high-spin isomer was observed, whilst in 96Ag 3 new isomeric states were identified, including core-excited states. In 98Cd a new high-energy isomeric γ-ray
The importance of having correct structural descriptions is becoming ever clearer, not only in drug discovery research, but also in the development of new advanced materials. Here the key to optimizing properties lies in understanding the structure-property relationships. Without a correct description theoretical calculations will inevitably fail to describe and explain any experimental observatio
Template-capped TiO2 nanostructures have been synthesized. In certain template conditions, TiO2 hexagons are found to form. These hexagonal structures can be effectively sensitized by fluorescein dye without any change in the protonation state of the dye. Bare TiO2 nanoparticles are not so useful for sensitization with dyes like fluorescein as they alter the dye protonation state. The novelty of t
In this study, one-to-one tuition in higher music education (HME) was theorised as a culturally and historically grounded activity system consisting of relation- ships between musicians, instruments, music-making traditions and audiences. The ‘skills paradox’, as seen in the inherent conflict between musicians’ need for long-term artistic training and society’s demands for flexible knowledge produ
Over the past decade, the chemistry of low-valent transition metal clusters has again come to the fore, primarily as a result of the development of nanochemistry and the realization that large clusters are on the cusp of the nano-domain. This perspective focuses on these recent developments in low-valent transition metal cluster chemistry, specifically looking at cluster-nanoparticles, the use of
Terrestrial cosmogenic nuclide dating in combination with detailed landform mapping in the Kongsf-jordhallet area, NW Svalbard, have provided new insight on configuration, dynamics, and deglaciation of the Late Weichselian Kongsfjorden ice stream. The minimum Late Weichselian ice surface elevation in Kongsfjorden was >449 m a.s.l. indicating considerably thicker ice and a steeper surface gradient
The use of quantitative performance measures to evaluate the productivity, impact and quality of research has spread to almost all parts of public R&D systems, including Big Science where traditional measures of technical reliability of instruments and user oversub- scription have been joined by publication counts to assess scientific productivity. But such performance assessment has been show
The parasites Leshmania mexicana and Trypanosoma cruzi cause serious health problems, and few efficient treatments are available. Recently, the two benzochromenes pulchrol (1) and pulchral (2) were reported from the roots of Bourreria pulchra, and especially 1 but also 2 was found to be active towards the parasites. In this paper, we present a total synthesis of 1 and 2 to facilitate their biologi
Secreted protein acidic and rich in cysteine (SPARC) is a matricellular glycoprotein that has been implicated in tumor-stroma interactions in pancreatic cancer. Here we evaluated the expression of SPARC during the progression of pancreatic cancer and its correlation with survival following curative intent surgery.
This paper examines how the aging population affects the generosity of public long-term care (LTC) in Sweden. Theoretically, aging has a direct effect on LTC policy because the elderly become a more important voter group. However, concerns for other citizens may dampen the political importance of the elderly. Fixed effects regressions on municipality-level panel data for 1999-2007 suggest that LTC
The Varberg-Torpa charnockite-granite association (Varberg, SW Sweden) consists of the magmatic Varberg charnockite (1399 +/- 6 Ma) and the Torpa granite (1380 +/- 12 Ma). The Torpa granite is both continuous and, based on its whole-rock geochemistry, synmagmatic with the Varberg charnockite. The granite body also contains a number of charnockite inliers. P-T estimation using garnet-clinopyroxene
Leaf-cutting ants combine large-scale herbivory with fungus farming to sustain advanced societies. Their stratified colonies are major evolutionary achievements and serious agricultural pests, but the crucial adaptations that allowed this mutualism to become the prime herbivorous component of neotropical ecosystems has remained elusive. Here we show how coevolutionary adaptation of a specific enzy
Urban areas adjacent to surface water are exposed to soil movements such as erosion and slope failures (landslides). A landslide is a potential mechanism for mobilisation and spreading of pollutants. This mechanism is in general not included in environmental risk assessments for contaminated sites, and the consequences associated with contamination in the soil are typically not considered in lands
In experimental studies, enkephalins (ENKs) and related opioids have been implicated as negative regulators of breast cancer development by enhancing immune-mediated tumoral defense as well as directly inhibiting cancer cells. We hypothesized that plasma levels of ENKs are predictive of the long-term breast cancer risk. Therefore, our objective was to measure pro-ENK A, a surrogate for mature ENK,
Physiological studies on olfaction frequently ignore the airborne quantities of stimuli reaching the sensory organ. We used a gas chromatography-calibrated photoionization detector to estimate quantities released from standard Pasteur pipette stimulus cartridges during repeated puffing of 27 compounds and verified how lack of quantification could obscure olfactory sensory neuron (OSN) affinities.
This review covers the main principles of the Lund concept for treatment of severe traumatic brain injury. This is followed by a description of results from clinical studies in which this therapy or a modified version of the therapy has been used. Unlike other guidelines, which are based on meta-analytical approaches, important components of the Lund concept are based on physiological mechanisms f
Background Eosinophils are pro-inflammatory cells implicated in the pathogenesis of asthma and atopy. Apoptosis has been proposed as a potential mechanism underlying the resolution of eosinophilic inflammation and studies have indicated the ability of interventions that induce human eosinophil apoptosis to promote the resolution of eosinophilic inflammation. Recently, the cyclin-dependent kinase (
The acquisition of nutrients is fundamental for the maintenance of bodily functions, growth, and reproduction in animals. As a result, fitness can be maximized only when animals are able to direct their attention to foods that reflect their current nutritional needs. Despite significant literature documenting the fitness consequences of nutrient composition and preference, less is known about the
