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Purpose: Patient-specific dosimetry is required to ensure the safety of molecular radiotherapy and to predict response. Dosimetry involves several steps, the first of which is the determination of the activity of the radiopharmaceutical taken up by an organ/lesion over time. As uncertainties propagate along each of the subsequent steps (integration of the time–activity curve, absorbed dose calcula
Avhandlingen består av fyra artiklar som alla kretsar kring hur ett effektivt nyttjande av infrastruktur kan uppnås. Tre av artiklarna berör externaliteter i transportsektorn medan den fjärde artikeln rör bostadsmarknaden och hur en skattereform påverkade äldre småhusägares flyttbeteende. Externaliteter uppstår när de beslut som en person (eller företag) tar har effekter även för andra och detta iAll four papers in the thesis share a common theme: how to achieve an efficient use of infrastructure and the built environment. In the presence of externalities, pricing according to the (short-run) marginal cost is one answer on how this can be achieved and the first two papers estimates parts of the marginal cost of traffic. Paper I examines the effect of road and railway noise on property pric
The Scanian Economic-Demographic Database (SEDD) at the Centre for Economic Demography (CED), Lund University was built to answer questions derived from previous research using macro data from 1749 onwards. It includes longitudinal micro data for a regional sample of rural, semi-urban, and urban parishes in southern Sweden from 1646 to 1968 for approximately 175,000 individuals. In addition to the
The transition of Escherichia coli from the exponential into the stationary phase of growth induces the stringent response, which is mediated by the rapid accumulation of the alarmone nucleotide (p)ppGpp produced by the enzyme RelA. The significance of RelA's functionality during the transition in the opposite direction, i.e. from the stationary phase into new exponential growth, is less well unde
Background and aim: Whether long-term oxygen therapy (LTOT) improves survival in interstitial lung disease (ILD) is unclear. A recent study reported similar survival in ILD patients with severe hypoxemia on LTOT vs. moderate hypoxemia without LTOT, and proposed that LTOT could be indicated in ILD already at moderate hypoxemia. The aim of this study was to compare survival by severity of hypoxemia
BACKGROUND: Loss of heterozygosity (LOH) at chromosome 1p is a common abnormality in both parathyroid tumors and pheochromocytomas. The recently characterized tumor suppressor gene RIZ1, located at 1p36, has emerged as a putative candidate to be involved in endocrine tumorigenesis.MATERIAL: Presence of allelic loss, promoter hypermethylation, and mutational aberrations of the RIZ1 gene were invest
Although co-infections and interactions of parasites are a very common phenomenon in the wild, information received from studies on avian Plasmodium spp. is scarce and fragmented due to its complex nature. Different interactions of parasites and domination of one parasite may have a detrimental effect on transmission success of another pathogen. Untangling these interactions and competitive behavi
Att planera lokal och regional kollektivtrafik i så kallade ’starka stråk’ – det vill säga att koncentrera infrastruktur och resurser till ett antal färre, men attraktivare stråk i en stad eller en region – är ett standardförfarande i samtida kollektivtrafikplanering. Så har inte alltid varit fallet dock. Denna avhandling visar hur organiseringen av beslutsfattande, planeringspraktiker och den rumPlanning local and regional public transport in so-called ’transit corridors’ – i.e., to concentrate infrastructure and resources to few, but more attractive corridors in a city or a region – is commonplace in contemporary public transport planning. This has not always been the case, however. In this thesis I analyze how transit corridors have come to dominate the policies and planning practices o
Objective: To study occupational groups and occupational exposure in association with chronic obstructive respiratory diseases. Methods: In early 2000s, structured interviews on chronic respiratory diseases and measurements of lung function as well as fractional expiratory nitric oxide (FENO) were performed in adult random population samples of Finland, Sweden and Estonia. Occupations were categor
Precarious employment (PE) is a well-known social determinant of health and health inequalities. However, as most previous studies have focused on physical and mental well-being, less is known about the social-related outcomes (ie, social precarity) associated with precarious arrangements. This cross-sectional study aims to investigate whether PE is associated with social precarity in a working po
Both disturbed sleep and lack of exercise can disrupt metabolism in pregnancy. Accelerometery was used to objectively assess movement during waking (physical activity) and movement during sleeping (sleep disturbance) periods and evaluated relationships with continuous blood glucose variation during pregnancy. Data was analysed prospectively. 15-women without pre-existing diabetes mellitus wore con
As a consequence of Sweden’s status as a non-belligerent country during World War II and the continuous growth of its welfare state thereafter, the concept of a “People’s Home” and a “provisional Utopia,” a social support system characterized by equality and material prosperity, were central aspects of the country’s postwar policy. This article focuses on the ideological and political stance of th
BACKGROUND: The St Gallen 2019 guidelines for primary therapy of early breast cancer recommend omission of completion axillary lymph node dissection (cALND), regardless of histological type, in patients with one or two sentinel lymph node (SLN) metastases. Concurrently, adjuvant chemotherapy is endorsed for luminal A-like disease with four or more axillary lymph node (ALN) metastases. The aim of t
The quantizer problem is a tessellation optimization problem where point configurations are identified such that the Voronoi cells minimize the second moment of the volume distribution. While the ground state (optimal state) in 3D is almost certainly the body-centered cubic lattice, disordered and effectively hyperuniform states with energies very close to the ground state exist that result as sta
The MAX IV 3 GeV storage ring is presently being commissioned and crucial parameters such as machine functions, emittance, and stored current have either already been reached or are approaching their design specifications [1, 2]. Once the baseline performance has been achieved, a campaign will be launched to further improve the brightness and coherence of this storage ring for typical x-ray users.
A numerical method was used to study the effect of the broken rib locations on the heat transfer and flow structure in the latticework duct with various rotational numbers. The latticework duct had eleven subchannels on both the pressure side and the suction side. The crossing angle for each subchannel was 45 deg. The numerical studies were conducted with five different broken rib locations and si
This paper presents a measurement of forward-forward and forward-central dijet azimuthal angular correlations and conditional yields in proton-proton (pp) and proton-lead (p+Pb) collisions as a probe of the nuclear gluon density in regions where the fraction of the average momentum per nucleon carried by the parton entering the hard scattering is low. In these regions, gluon saturation can modify
A measurement of the associated production of a top-quark pair (tt) with a vector boson (W, Z) in proton-proton collisions at a center-of-mass energy of 13 TeV is presented, using 36.1 fb-1 of integrated luminosity collected by the ATLAS detector at the Large Hadron Collider. Events are selected in channels with two same- or opposite-sign leptons (electrons or muons), three leptons or four leptons
