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Infant and adult MLL1/KMT2A-rearranged (MLLr) leukemia represents a disease with a dismal prognosis. Here, we present a functional and proteomic characterization of in utero-initiated and adult-onset MLLr leukemia. We reveal that fetal MLL::ENL-expressing lymphomyeloid multipotent progenitors (LMPPs) are intrinsically programmed towards a lymphoid fate but give rise to myeloid leukemia in vivo, hi
In response to concerns about depleting natural resources, organisations are developing eco-friendly products and services. This study examines the role of manufacturing industries and services in sustainable resource utilisation, focusing on the Micro, Small, Medium Enterprises (MSME) sector, a significant contributor to global Gross Domestic Product (GDP). Using Life Cycle Assessment (LCA) metho
Feminism has become a recurrent ingredient in many women's narratives of their selves and is regularly appearing as an important aspect of women's success, happiness and self‐realization. The development has been criticized for upholding a view in which structural inequalities are explained in terms of individual choices; choice feminism. This article examines two professional groups, lifestyle in
Open office environments are architectural solutions that are believed to economize the use of office space and facilitate social interactions at work. However, research has shown that employees in open office environments may experience lower job satisfaction, stress reactions, and exhibit poorer performance. Exposure to noise in open office environments may prompt avoidance behaviours such as wo
In the last thirty years, the field of education and educational policymaking has become increasingly internationalized. Consequently, more actors, especially actors beyond the national level have become interested and involved in educational policymaking. International Organizations (IOs) in particular have become prominent in the educational sphere and their role in affecting and defining educat
One of the most harmful social issues throughout the world is crime, making it an important subject to research. This essay investigates the relationship between violent crime and oil prices in Europe and Central Asia. The relationship is less researched than crime and other socioeconomic variables such as unemployment and economic growth. The casual relationship is tested using the PVAR model and
In light of declining multilateralism within the field of human rights since the 1990s, National Human Rights Institutions have been presented by the UN as translators capable of vernacularizing and institutionalizing global human rights ideals within the local. Yet, the global proliferation of National Human Rights Institutions sparked by the adoption of the UN Principles Relating to the Status o
Numerous broad insights have emerged in the last decades concerning the invasive non-indigenous round goby (Neogobius melanostomus) and its expanding presence in the Baltic Sea. The waters surrounding the Danish isles are the final frontiers separating the Baltic Sea from the North Sea, and although they offer highly favourable habitats, the biotic resistance in Öresund by native competitors might
Offer för brott mot mänskliga rättigheter orsakade av multinationella företags aktiviteter möter stora rättsliga luckor och hinder när de försöker utkräva kompensation för skador. Bolagsrätten som täcker dessa situationer har inte ännu anpassats till förändringarna som den globaliserade världen inneburit, och de komplexa strukturerna som multinationella företag består av idag. Principen som innebVictims of human rights abuses linked to activities of multinational corporations face huge legal gaps and challenges when trying to access compensation for harm. Corporate law covering these scenarios have not yet adapted to the changes of a globalized world and the complex structures of today’s multinational corporations (MNCs). The principle of separate legal entities is one such obstacle keep
The liver oil from C. monstrosa (rat fish) has traditionally been used as a natural remedy in the area around Skagerrak, since it is believed to have a wound healing and analgesic effects. On its back the rat fish carries a vigorous venom spine connected to glandular cells, which secrets toxins. A previous study shows that extract from the liver and venom glands had a cytotoxic activity on A. naup
Den här uppsatsen undersöker hur gemenskaper skapas i den livestreamade konserten The Tallest Man on Earth - The Wild Hunt Live #StayHome #WithMe som hölls 10-04-2020 på video-plattformen Youtube. I uppsatsen analyseras fanaktivitet vid spelningen med hjälp av en netnografisk metod, samt en kvalitativ innehållsanalys. Uppsatsen utgår från teorier om fankulturer, föreställda gemenskaper och deltaga
Cirrus clouds are high-level ice clouds covering ≈ 30% of Earth’s surface. The cirrus clouds ice crystals can be formed by heterogeneous or homogeneous nucleation, where temperatures for heterogeneous nucleation was set to -38 - -30 °C and for homogeneous nucleation below -42 °C. The study will focus on microphysical properties of cirrus clouds in the tropics, 0-30°, and the mid-latitudes, 30-60°,
In the ever evolving and ambiguous environment of VAT treatment of sales of shares, the underlying purpose test has arisen as a new form of controversy. While it seems to be a viable method for establishing in specific circumstances a strong enough direct and immediate link to guarantee deduction also for costs incurred in relation to an exempt or out-of-scope share disposal, the test’s nature and
In 2018, the Swedish Supreme Administrative Court decided in a case. The decision of the court, came to change the scope of the exemption for medical care in Sweden. The court ruled that the hiring out of medical care staff is to be regarded as a taxable service and not exempted from VAT. This interpretation has raised many questions and opinions. One of them is the compatibility of the interpreta
Globalisation has expanded investors’ financial reach and while most investments occur without much attention, some lead to disagreements and divergent responses from consumers. Therefore, this paper aims at providing a comprehensive picture of consumers’ responses following investments that become a matter of controversy. This research problem was addressed through the case of Oatly’s consumers’
This thesis explores the labour integration of documented-non-European immigrants into the Swedish labour market through their immigrants' networks. Most documented-non-European immigrants face labour integration challenges due to the lack of specific labour skills. In Sweden's case, most jobs on the labor market are highly-skilled jobs that require that the immigrant acquires or possesses
