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The pTalpha promoter and enhancer are direct targets for transactivation by E box-binding proteins.

The pre-Talpha (pTalpha[?]) gene encodes a protein that forms the pre-TCR together with the newly expressed TCR beta chain during a defined stage of early T cell development. The restricted expression of this gene has been suggested to depend on a promoter and an enhancer element containing E boxes, which are potential binding sites for basic helix-loop-helix (bHLH) proteins. We here report that i

Body size and risk of colon and rectal cancer in the European prospective investigation into cancer and nutrition (EPIC)

Background: Body weight and body mass index (BMI) are positively related to risk of colon cancer in men, whereas weak or no associations exist in women. This discrepancy may be related to differences in fat distribution between sexes or to the use of hormone replacement therapy (HRT) in women. Methods: We used multivariable adjusted Cox proportional hazards models to examine the association betwee

Genetic basis of lacunar stroke : a pooled analysis of individual patient data and genome-wide association studies

Background: The genetic basis of lacunar stroke is poorly understood, with a single locus on 16q24 identified to date. We sought to identify novel associations and provide mechanistic insights into the disease. Methods: We did a pooled analysis of data from newly recruited patients with an MRI-confirmed diagnosis of lacunar stroke and existing genome-wide association studies (GWAS). Patients were

Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism

Interactions between host and gut microbial communities are modulated by diets and play pivotal roles in immunological homeostasis and health. We show that exchanging the protein source in a high fat, high sugar, westernized diet from casein to whole-cell lysates of the non-commensal bacterium Methylococcus capsulatus Bath is sufficient to reverse western diet-induced changes in the gut microbiota

UNITY: A low-field magnetic resonance neuroimaging initiative to characterize neurodevelopment in low and middle-income settings

Measures of physical growth, such as weight and height have long been the predominant outcomes for monitoring child health and evaluating interventional outcomes in public health studies, including those that may impact neurodevelopment. While physical growth generally reflects overall health and nutritional status, it lacks sensitivity and specificity to brain growth and developing cognitive skil

Consumption of ultra-processed foods and risk of multimorbidity of cancer and cardiometabolic diseases : a multinational cohort study

Background: It is currently unknown whether ultra-processed foods (UPFs) consumption is associated with a higher incidence of multimorbidity. We examined the relationship of total and subgroup consumption of UPFs with the risk of multimorbidity defined as the co-occurrence of at least two chronic diseases in an individual among first cancer at any site, cardiovascular disease, and type 2 diabetes.

Age at Menopause and the Risk of Stroke : Observational and Mendelian Randomization Analysis in 204 244 Postmenopausal Women

BACKGROUND: Observational studies have shown that women with an early menopause are at higher risk of stroke compared with women with a later menopause. However, associations with stroke subtypes are inconsistent, and the causality is unclear. METHODS AND RESULTS: We analyzed data of the UK Biobank and EPIC-CVD (European Prospective Investigation Into Cancer and Nutrition-Cardiovascular Diseases)

Sequence variants influencing the regulation of serum IgG subclass levels

Immunoglobulin G (IgG) is the main isotype of antibody in human blood. IgG consists of four subclasses (IgG1 to IgG4), encoded by separate constant region genes within the Ig heavy chain locus (IGH). Here, we report a genome-wide association study on blood IgG subclass levels. Across 4334 adults and 4571 individuals under 18 years, we discover ten new and identify four known variants at five loci

Myeloid Kdm6b deficiency results in advanced atherosclerosis

BACKGROUND AND AIMS: Atherosclerosis is a lipid-driven chronic inflammatory disorder of the arteries, and monocytes and macrophages play a central role in this process. Within the atherosclerotic lesion, macrophages can scavenge modified lipids and become the so-called foam cells. We previously reported that the epigenetic enzyme Kdm6b (also known as Jmjd3) controls the pro-fibrotic transcriptiona

Lymphatic Disorder Management in Pediatric Patients With Congenital Heart Disease in European Pediatric Cardiology Centers : Current Status, Disparities, and Future Considerations

BACKGROUND: Lymphatic disorders such as protein-losing enteropathy, plastic bronchitis, and chylothorax are important complications of the Fontan circulation and ultimately result in an increased risk of early death. Several European centers are now performing lymphatic procedures. The aim of this study is to map the extent of these lymphatic disorders and treatments provided across European pedia

Genomic and transcriptomic features of androgen receptor signaling inhibitor resistance in metastatic castration-resistant prostate cancer

BACKGROUNDAndrogen receptor signaling inhibitors (ARSIs) have improved outcomes for patients with metastatic castration-resistant prostate cancer (mCRPC), but their clinical benefit is limited by treatment resistance.METHODSTo investigate the mechanisms of ARSI resistance, we analyzed the whole-genome (n = 45) and transcriptome (n = 31) sequencing data generated from paired metastatic biopsies obt

Systematic review and meta-analysis of humoral immunity proteins and mortality in sepsis

Purpose: Humoral immunity proteins—immunoglobulins, complement proteins, and antimicrobial peptides—have key antimicrobial and immunomodulatory functions in sepsis. We hypothesised that their circulating levels are lower in non-survivors, potentially resulting in impaired bacterial clearance and persistent or recurrent infections. Methods: We performed a systematic review and meta-analysis evaluat

Webb – Biologibloggen

Webb – Biologibloggen Hoppa till huvudinnehåll Om Biologibloggen Tillgänglighet Kontakt Sök Sök Stäng Meny Biologibloggen Biologiska institutionen | Lunds universitet Arkiv för kategorin Webb Sida 1 / 1 november 19, 2020 | Inger Ekström Simpler website launched – even better with your help Blog post updated 2020-12-03. New FAQ at the end of this post. As you probably have seen, we launched a new w

https://biologi.blogg.lu.se/category/webb/ - 2026-06-23

Utilization of hardwood in cross-laminated timber

Utilization of hardwood in cross-laminated timber Master’s Dissertation Structural Mechanics JOHANNES JONASSON and OLLE KARLSSON UTILISATION OF HARDWOOD IN CROSS-LAMINATED TIMBER A numerical study on vibrations in floors DEPARTMENT OF CONSTRUCTION SCIENCES DIVISION OF STRUCTURAL MECHANICS ISRN LUTVDG/TVSM--22/5258--SE (1-133) | ISSN 0281-6679 MASTER’S DISSERTATION Supervisor: PETER PERSSON, Associ

https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm5000/web5258.pdf - 2026-06-22

Uppsatsmall

Uppsatsmall 1 Lärare skriver 2 Lärare skriver Ingrid Bosseldal (redaktör) Sara Andersson Elin Bolkéus Linda Claremar Martin Ekenvärn Anna Charlotta Gräslund Bente Halvorsen Louise Hansson Åsa Isaksson Johnny Normark Friskilä Hanna Olenius Lina Pascal Lisbet Zacconi Malmodin Elisabet Övermo Copyright Författarna Institutionen för utbildningsvetenskap Humanistiska och teologiska fakulteterna Lunds u

https://www.uvet.lu.se/fileadmin/user_upload/uvet/lararutbildning/Laerare_skriver_Digital_antologi_2023.pdf - 2026-06-22

Microsoft Word - Försättssidor2003-02-02.doc

Microsoft Word - Försättssidor2003-02-02.doc Doctoral Thesis Structural Mechanics TOMAS NORDSTRAND BASIC TESTING AND STRENGTH DESIGN OF CORRUGATED BOARD AND CONTAINERS Detta är en tom sida! Copyright © Tomas Nordstrand, 2003. Printed by KFS i Lund AB, Lund, Sweden, February 2003. For information, address: Division of Structural Mechanics, LTH, Lund University, Box 118, SE-221 00 Lund, Sweden. Home

https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm1000/web1015.pdf - 2026-06-22

Transcriptome-wide association study reveals candidate causal genes for lung cancer

We have recently completed the largest GWAS on lung cancer including 29,266 cases and 56,450 controls of European descent. The goal of our study has been to integrate the complete GWAS results with a large-scale expression quantitative trait loci (eQTL) mapping study in human lung tissues (n = 1,038) to identify candidate causal genes for lung cancer. We performed transcriptome-wide association st

Svensson Cedergren Andreen Messing - Motivation och egenintresse

Svensson Cedergren Andreen Messing - Motivation och egenintresse LTHs 9:e Pedagogiska Inspirationskonferens, 15 december 2016 Abstract — En viktig del av universitetsutbildningen är examensarbetet, en undervisningsform, som bygger på förtroende och förståelse mellan student och handledare. Syftet med den här studien var att undersöka vad som motiverar forskare att handleda examensarbeten kopplat t

https://www.lth.se/fileadmin/lth/genombrottet/konferens2016/12_Svensson_etal.pdf - 2026-06-09

ALL students of the department – STUDIEVÄGLEDARBLOGGEN

ALL students of the department – STUDIEVÄGLEDARBLOGGEN Hoppa till huvudinnehåll Hem Studievägledaren vid Institutionen för arkeologi och antikens historia i Lund Lära sig vara student Sök Sök Stäng Meny Meny STUDIEVÄGLEDARBLOGGEN Blandad information för studenter på Institutionen för arkeologi och antikens historia vid Lunds universitet Arkiv för kategorin ALL students of the department Sida 1 / 3

https://arkstudier.blogg.lu.se/category/students-of-the-department/ - 2026-06-22