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Several stilbenoid compounds having structural similarity to the combretastatin group of natural products and characterized by the incorporation of two nitrogen-bearing groups (amine, nitro, serinamide) have been prepared by chemical synthesis and evaluated in terms of biochemical and biological activity. The 2',3'-diamino B-ring analogue 17 demonstrated remarkable cytotoxicity against selected hu

Context:Late-onset hypogonadism (LOH) has been defined as a syndrome in middle-aged and elderly men reporting symptoms in the presence of low testosterone (T). Objective:The objective of the study was to seek objective biochemical and end-organ evidence of androgen deficiency in men classified as having LOH according to our previously published criteria. Design, Setting, and Participants:The des

Plasmacytoid dendritic cells (pDCs) efficiently produce large amounts of type I IFN in response to TLR7 and TLR9 ligands, whereas conventional DCs (cDCs) predominantly secrete high levels of the cytokines IL-10 and IL-12. The molecular basis underlying this distinct phenotype is not well understood. In this study, we identified the MAPK phosphatase Dusp9/MKP-4 by transcriptome analysis as selectiv

The existence of a vertical age gradient in the Milky Way disc has been indirectly known for long. Here, we measure it directly for the first time with seismic ages, using red giants observed by Kepler. We use Stromgren photometry to gauge the selection function of asteroseismic targets, and derive colour and magnitude limits where giants with measured oscillations are representative of the underl

The oomycete Phytophthora infestans is the causal agent of late blight in potato and tomato. Since the underlying processes that govern pathogenicity and development in P. infestans are largely unknown, we have performed a large-scale phosphoproteomics study of six different P. infestans life stages. We have obtained quantitative data for 2922 phosphopeptides and compared their abundance. Life-sta

Popular Abstract in Swedish Bomärken har använts som ägarbeteckning och signatur i Norden in på 1800-talet, och i vissa reliktområden intill nutid. Bomärkena återfinns t.ex. i mantalslängder, jordaböcker och bouppteckningar, men även inskurna på äldre redskap, husgeråd och annat lösöre. Bomärkena har av somliga forskare ansetts ha utformats slumpvis, enbart med syftet att kunna skilja en bomärkesThe pioneering academic research on Merchant Marks (also known as identity marks, personal marks, ownership marks, identification marks, Hausmarken, Hofmarken, Marques de Propriété, bomärken) was done by professor Homeyer (1870). Since 1870 there has been an ongoing debate among scholars whether Merchant Marks are simply formed by chance and coincidence, as stated by Rehnberg (1938, 1951), Scheffe

Popular Abstract in Swedish Denna studie betonar att de mekanismer, som skapar tillväxt, inte nödvändigtvis är universella utan kan skilja sig åt mellan olika områden, beroende på vad som produceras och vilken teknik som används. Avhandlingen hävdar inledningsvis att ekonomisk tillväxt är den viktigaste enskilda faktor som påverkar individers inkomstnivå och att ökad produktivitet i sin tur är gruThis study shows that the mechanisms behind knowledge accumulation and the sources of productivity growth differ from industry to industry depending on what is produced and what technology is used. Although it is apparent to most researchers in the field that the only way to explain long-run growth in output per capita is through technological progress and accumulation of knowledge that counteract

The mucosal lymphocyte integrin alpha E(CD103)beta 7 is thought to be important for intraepithelial lymphocyte (IEL) localization or function. We cloned the murine integrin gene encoding alpha E, localized it to chromosome 11, and generated integrin alpha E-deficient mice. In alpha E-/- mice, intestinal and vaginal IEL numbers were reduced, consistent with the known binding of alpha E beta 7 to E-

The ion photon emission microscope, or IPEM, is the first device that allows scientists to microscopically study the effects of single ions in air on semiconductors, microchips and even biological cells without having to focus the beam. Reported here is a prototype, the size of a conventional optical microscope, developed at Sandia. The alpha-IPEM, that employs alpha particles from a radioactive s

Given the uncertainty and complexity of security risk analyses, there is a great need of tools for contextual inquiry supporting assessment of risk with multi-value scales according to different stakeholders’ point of view. Such tools can be used at individual level to help develop the understanding of a problem space. At the collective level, they can be used as a mean of communication to support

The Relativistic Heavy Ion Collider (RHIC) has made it possible to study hadronic matter under unprecedented conditions in terms of temperature and energy density. Global variables are essential for the characterization of nuclear collisions at ultra-relativistic energies. The PHENIX experiment has several detectors which provide information about the global properties and hence the initial condit

Popular Abstract in Swedish Melamisufism (melamet) fanns i olika delar av Osmanska riket. Den sista perioden, då melamirörelsen var särskilt märkbar, tar sin början i slutet av 1800-talet, och då med en koncentration i den europeiska delen av det osmanska riket (Rumeli). Detta hänger samman med att melamiordens huvudschejk Sejjid Muhammed Nur el-Arebi, bodde och var verksam där under denna tid. MeThis dissertation focuses on Melami history in Bosnia with emphasis on the 20th century. The well-known Melami master Hajrullah Abdurahmanovic (d. 1965) in this study becomes an exponent for changes in the political and social role of religion in course of the 20th century. The purpose of this research is to describe and analyze the theology of the Melami movement in the environments created by su

Context: The diagnosis of late-onset hypogonadism (LOH) in older men with age-related declines in testosterone (T) is currently not well characterized. Objective: Our objective was to investigate whether different forms of hypogonadism can be distinguished among aging men. Design: The study was a cross-sectional survey on 3369 community-dwelling men aged 40-79 yr in eight European centers. Methods

Context: Limited data are available exploring the associations between sex hormones, multiple domains of sexual functioning, and sexual function-related distress in nonpatient samples in Europe. Objectives: The aim of the study was to investigate the relationships between serum testosterone (T), estradiol (E2), and dihydrotestosterone (DHT) and sexual function in a multicenter population-based stu

We present deep Hubble Space Telescope ACS observations of the G1 clump, a distinct stellar overdensity lying at similar to 30 kpc along the southwestern major axis of M31, close to the G1 globular cluster ( from the work of Ferguson and coworkers). Our well-populated color-magnitude diagram reaches similar to 7 mag below the red giant branch tip with 90% completeness, and allows the detection of

Popular Abstract in Swedish Vad är egentligen kristen etik? Hur lär människor sig vad som är rätt och fel? Varför förändras normer och värderingar? Sådana stora och viktiga frågor får en konkret belysning i denna avhandling som undersöker normer och värderingar i svensk frikyrklighet. Lite ironiskt sa man förr att frikyrkliga hade en "syndakatalog": de fick exempelvis inte snusa, dansa eller ha sThe dissertation describes and characterises ethical reflection in the Swedish Free Churches during the period from the 1930s to the 1990s. It is built primarily on two sources of material. The first one is a summary of discussions and statements on marriage, divorce and remarriage from books, journals and papers, mainly from two denominations: the Swedish Covenant Church and the Örebromission. Th

The electronic structure of GaAs (100) grown by low-temperature molecular beam epitaxy was investigated by means of photoemission spectroscopy. Slight differences are found in the valence band spectra of GaAs layers grown at different As-2/Ga flux ratios. Analysis of As 3d core level spectra does not indicate qualitative differences in respect to high temperature grown GaAs (100) layers. The Ga 3d

This study of stress-related antinuclear antibody (ANA) reactivity was undertaken with the objective of improving clinical ANA testing. ANA was determined by parallel enzyme-linked immunosorbent assays of crude nuclear protein antigen extracted from HEp-2 cells either grown under optimal conditions (providing nonstress ANA antigen) or exposed to stress (providing stress ANA antigen). The stress st